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Efficacy and safety of olaparib monotherapy in germline BRCA1/2 mutation carriers with advanced ovarian cancer and three or more lines of prior therapy.

Domchek, Susan M ; Aghajanian, Carol ; Shapira-Frommer, Ronnie ; Schmutzler, Rita K ; Audeh, M William ; Friedlander, Michael ; Balmaña, Judith ; Mitchell, Gillian ; Fried, Georgeta and Stemmer, Salomon M , et al. (2016) In Gynecologic Oncology 140(2). p.199-203
Abstract
The efficacy and safety of olaparib, an oral poly(ADP-ribose) polymerase (PARP) inhibitor, was investigated in a subgroup of patients with germline BRCA1/2 mutated (gBRCA1/2m) advanced ovarian cancer who had received ≥3 prior lines of chemotherapy. Primary data from this Phase II study (Study 42, ClinicalTrials.govNCT01078662) have been reported previously.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Gynecologic Oncology
volume
140
issue
2
pages
199 - 203
publisher
Academic Press
external identifiers
  • pmid:26723501
  • scopus:84953204390
  • wos:000369678900003
  • pmid:26723501
ISSN
1095-6859
DOI
10.1016/j.ygyno.2015.12.020
language
English
LU publication?
yes
id
daa777d4-7791-4af0-8cab-a193c1fe9991 (old id 8593401)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26723501?dopt=Abstract
date added to LUP
2016-04-04 07:23:34
date last changed
2022-04-23 07:57:12
@article{daa777d4-7791-4af0-8cab-a193c1fe9991,
  abstract     = {{The efficacy and safety of olaparib, an oral poly(ADP-ribose) polymerase (PARP) inhibitor, was investigated in a subgroup of patients with germline BRCA1/2 mutated (gBRCA1/2m) advanced ovarian cancer who had received ≥3 prior lines of chemotherapy. Primary data from this Phase II study (Study 42, ClinicalTrials.govNCT01078662) have been reported previously.}},
  author       = {{Domchek, Susan M and Aghajanian, Carol and Shapira-Frommer, Ronnie and Schmutzler, Rita K and Audeh, M William and Friedlander, Michael and Balmaña, Judith and Mitchell, Gillian and Fried, Georgeta and Stemmer, Salomon M and Hubert, Ayala and Rosengarten, Ora and Loman, Niklas and Robertson, Jane D and Mann, Helen and Kaufman, Bella}},
  issn         = {{1095-6859}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{199--203}},
  publisher    = {{Academic Press}},
  series       = {{Gynecologic Oncology}},
  title        = {{Efficacy and safety of olaparib monotherapy in germline BRCA1/2 mutation carriers with advanced ovarian cancer and three or more lines of prior therapy.}},
  url          = {{http://dx.doi.org/10.1016/j.ygyno.2015.12.020}},
  doi          = {{10.1016/j.ygyno.2015.12.020}},
  volume       = {{140}},
  year         = {{2016}},
}