NSAIDs and Cardiovascular Diseases : Role of Reactive Oxygen Species
(2015) In Oxidative Medicine and Cellular Longevity 2015.- Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs worldwide. NSAIDs are used for a variety of conditions including pain, rheumatoid arthritis, and musculoskeletal disorders. The beneficial effects of NSAIDs in reducing or relieving pain are well established, and other benefits such as reducing inflammation and anticancer effects are also documented. The undesirable side effects of NSAIDs include ulcers, internal bleeding, kidney failure, and increased risk of heart attack and stroke. Some of these side effects may be due to the oxidative stress induced by NSAIDs in different tissues. NSAIDs have been shown to induce reactive oxygen species (ROS) in different cell types including cardiac and cardiovascular... (More)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs worldwide. NSAIDs are used for a variety of conditions including pain, rheumatoid arthritis, and musculoskeletal disorders. The beneficial effects of NSAIDs in reducing or relieving pain are well established, and other benefits such as reducing inflammation and anticancer effects are also documented. The undesirable side effects of NSAIDs include ulcers, internal bleeding, kidney failure, and increased risk of heart attack and stroke. Some of these side effects may be due to the oxidative stress induced by NSAIDs in different tissues. NSAIDs have been shown to induce reactive oxygen species (ROS) in different cell types including cardiac and cardiovascular related cells. Increases in ROS result in increased levels of oxidized proteins which alters key intracellular signaling pathways. One of these key pathways is apoptosis which causes cell death when significantly activated. This review discusses the relationship between NSAIDs and cardiovascular diseases (CVD) and the role of NSAID-induced ROS in CVD.
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- author
- Ghosh, Rajeshwary ; Alajbegovic, Azra LU and Gomes, Aldrin V
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- keywords
- Anti-Inflammatory Agents, Non-Steroidal, Arthritis, Cardiovascular Diseases, Cytochrome P-450 Enzyme System, Humans, Incidence, Lipoxygenase, Mitochondria, NADPH Oxidase, Nitric Oxide Synthase, Reactive Oxygen Species, Xanthine Oxidase, Journal Article, Research Support, Non-U.S. Gov't, Review
- in
- Oxidative Medicine and Cellular Longevity
- volume
- 2015
- article number
- 536962
- pages
- 25 pages
- publisher
- Hindawi Limited
- external identifiers
-
- scopus:84943240525
- pmid:26457127
- ISSN
- 1942-0994
- DOI
- 10.1155/2015/536962
- language
- English
- LU publication?
- no
- id
- 85a0a3dc-25eb-4f1b-824d-b2597d10525b
- date added to LUP
- 2016-12-08 13:28:04
- date last changed
- 2024-04-05 12:22:51
@article{85a0a3dc-25eb-4f1b-824d-b2597d10525b,
abstract = {{<p>Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs worldwide. NSAIDs are used for a variety of conditions including pain, rheumatoid arthritis, and musculoskeletal disorders. The beneficial effects of NSAIDs in reducing or relieving pain are well established, and other benefits such as reducing inflammation and anticancer effects are also documented. The undesirable side effects of NSAIDs include ulcers, internal bleeding, kidney failure, and increased risk of heart attack and stroke. Some of these side effects may be due to the oxidative stress induced by NSAIDs in different tissues. NSAIDs have been shown to induce reactive oxygen species (ROS) in different cell types including cardiac and cardiovascular related cells. Increases in ROS result in increased levels of oxidized proteins which alters key intracellular signaling pathways. One of these key pathways is apoptosis which causes cell death when significantly activated. This review discusses the relationship between NSAIDs and cardiovascular diseases (CVD) and the role of NSAID-induced ROS in CVD.</p>}},
author = {{Ghosh, Rajeshwary and Alajbegovic, Azra and Gomes, Aldrin V}},
issn = {{1942-0994}},
keywords = {{Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Cytochrome P-450 Enzyme System; Humans; Incidence; Lipoxygenase; Mitochondria; NADPH Oxidase; Nitric Oxide Synthase; Reactive Oxygen Species; Xanthine Oxidase; Journal Article; Research Support, Non-U.S. Gov't; Review}},
language = {{eng}},
publisher = {{Hindawi Limited}},
series = {{Oxidative Medicine and Cellular Longevity}},
title = {{NSAIDs and Cardiovascular Diseases : Role of Reactive Oxygen Species}},
url = {{http://dx.doi.org/10.1155/2015/536962}},
doi = {{10.1155/2015/536962}},
volume = {{2015}},
year = {{2015}},
}