The seasonal importance of serum 25-hydroxyvitamin D for bone mineral density in older women.
(2017) In Journal of Internal Medicine 281(2). p.167-178- Abstract
- Background
The impact of season when determining a serum 25-hydroxyvitamin D (S-25OHD) cut-off level for optimal bone health is unknown.
Objective
To investigate the relative importance of S-25OHD for bone mineral density (BMD) by season.
Methods
A subcohort of 5002 Swedish women (mean age 68 years), randomly selected from a large population-based longitudinal cohort study with repeat dietary and lifestyle information, was enrolled during 2003–2009 for a clinical examination, which included dual-energy X-ray absorptiometry and collection of fasting blood samples. Categories of vitamin D status were determined by S-25OHD (measured by HPLC-MS/MS).
Results
In samples collected during summer, we found... (More) - Background
The impact of season when determining a serum 25-hydroxyvitamin D (S-25OHD) cut-off level for optimal bone health is unknown.
Objective
To investigate the relative importance of S-25OHD for bone mineral density (BMD) by season.
Methods
A subcohort of 5002 Swedish women (mean age 68 years), randomly selected from a large population-based longitudinal cohort study with repeat dietary and lifestyle information, was enrolled during 2003–2009 for a clinical examination, which included dual-energy X-ray absorptiometry and collection of fasting blood samples. Categories of vitamin D status were determined by S-25OHD (measured by HPLC-MS/MS).
Results
In samples collected during summer, we found a gradual increase in BMD of the total hip up to a S-25OHD level of 40 nmol L−1 (6% of the cohort). In women with S-25OHD concentrations below 30 nmol L−1 during summer, adjusted BMD was 11% lower [95% confidence interval (CI) 3–19] and in those with S-25OHD levels of 30–40 nmol L−1 BMD was 6% lower (95% CI 1–11), compared with women with S-25OHD levels above 80 nmol L−1. Low S-25OHD concentrations during summer (<30 nmol L−1) were also associated with higher adjusted relative risk of osteoporosis (4.9; 95% CI 2.9–8.4) compared with concentrations above 80 nmol L−1. By contrast, no differences in mean BMD values between categories of S-25OHD were found during winter.
Conclusions
Summer concentrations of S-25OHD appear to be the most useful to predict BMD, whereas winter levels have limited value. To determine a S-25OHD cut-off level for vitamin D deficiency, it may be necessary to take into account the season of blood collection. (Less)
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https://lup.lub.lu.se/record/86c3421a-e5f8-4cf9-ab93-b5fbe4ea7eed
- author
- Michaëlsson, Karl ; Wolk, Alicja ; Byberg, Liisa ; Mitchell, Adam LU ; Mallmin, Hans and Melhus, Håkan
- publishing date
- 2017-02
- type
- Contribution to journal
- publication status
- published
- in
- Journal of Internal Medicine
- volume
- 281
- issue
- 2
- pages
- 167 - 178
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85010471763
- ISSN
- 1365-2796
- DOI
- 10.1111/joim.12563
- language
- English
- LU publication?
- no
- id
- 86c3421a-e5f8-4cf9-ab93-b5fbe4ea7eed
- date added to LUP
- 2025-02-07 12:00:54
- date last changed
- 2025-02-08 04:01:57
@article{86c3421a-e5f8-4cf9-ab93-b5fbe4ea7eed,
abstract = {{Background<br/>The impact of season when determining a serum 25-hydroxyvitamin D (S-25OHD) cut-off level for optimal bone health is unknown.<br/><br/>Objective<br/>To investigate the relative importance of S-25OHD for bone mineral density (BMD) by season.<br/><br/>Methods<br/>A subcohort of 5002 Swedish women (mean age 68 years), randomly selected from a large population-based longitudinal cohort study with repeat dietary and lifestyle information, was enrolled during 2003–2009 for a clinical examination, which included dual-energy X-ray absorptiometry and collection of fasting blood samples. Categories of vitamin D status were determined by S-25OHD (measured by HPLC-MS/MS).<br/><br/>Results<br/>In samples collected during summer, we found a gradual increase in BMD of the total hip up to a S-25OHD level of 40 nmol L−1 (6% of the cohort). In women with S-25OHD concentrations below 30 nmol L−1 during summer, adjusted BMD was 11% lower [95% confidence interval (CI) 3–19] and in those with S-25OHD levels of 30–40 nmol L−1 BMD was 6% lower (95% CI 1–11), compared with women with S-25OHD levels above 80 nmol L−1. Low S-25OHD concentrations during summer (<30 nmol L−1) were also associated with higher adjusted relative risk of osteoporosis (4.9; 95% CI 2.9–8.4) compared with concentrations above 80 nmol L−1. By contrast, no differences in mean BMD values between categories of S-25OHD were found during winter.<br/><br/>Conclusions<br/>Summer concentrations of S-25OHD appear to be the most useful to predict BMD, whereas winter levels have limited value. To determine a S-25OHD cut-off level for vitamin D deficiency, it may be necessary to take into account the season of blood collection.}},
author = {{Michaëlsson, Karl and Wolk, Alicja and Byberg, Liisa and Mitchell, Adam and Mallmin, Hans and Melhus, Håkan}},
issn = {{1365-2796}},
language = {{eng}},
number = {{2}},
pages = {{167--178}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Internal Medicine}},
title = {{The seasonal importance of serum 25-hydroxyvitamin D for bone mineral density in older women.}},
url = {{http://dx.doi.org/10.1111/joim.12563}},
doi = {{10.1111/joim.12563}},
volume = {{281}},
year = {{2017}},
}