How should antibodies against P. falciparum merozoite antigens be measured?
(2013) In Journal of Tropical Medicine- Abstract
- Immunity against malaria develops slowly and only after repeated exposure to the parasite. Many of those that die of the disease are children under five years of age. Antibodies are an important part of immunity, but which antibodies that are protective and how these should be measured are still unclear. We discuss the pros and cons of ELISA, invasion inhibition assays/ADCI, and measurement of affinity of antibodies and what can be done to improve these assays, thereby increasing the knowledge about the immune status of an individual, and to perform better evaluation of vaccine trials.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8726813
- author
- Chuangchaiya, S. and Persson, Kristina LU
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- antibody, antigen, malaria vaccine, merozoite antigen, unclassified drug
- in
- Journal of Tropical Medicine
- article number
- 493834
- publisher
- Hindawi Limited
- external identifiers
-
- scopus:84877258320
- pmid:23690791
- ISSN
- 1687-9686
- DOI
- 10.1155/2013/493834
- language
- English
- LU publication?
- no
- id
- 2c707369-d30d-40b5-ad6f-5aa0b01f2851 (old id 8726813)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23690791
- date added to LUP
- 2016-04-01 14:26:08
- date last changed
- 2024-01-10 03:48:15
@article{2c707369-d30d-40b5-ad6f-5aa0b01f2851,
abstract = {{Immunity against malaria develops slowly and only after repeated exposure to the parasite. Many of those that die of the disease are children under five years of age. Antibodies are an important part of immunity, but which antibodies that are protective and how these should be measured are still unclear. We discuss the pros and cons of ELISA, invasion inhibition assays/ADCI, and measurement of affinity of antibodies and what can be done to improve these assays, thereby increasing the knowledge about the immune status of an individual, and to perform better evaluation of vaccine trials.}},
author = {{Chuangchaiya, S. and Persson, Kristina}},
issn = {{1687-9686}},
keywords = {{antibody; antigen; malaria vaccine; merozoite antigen; unclassified drug}},
language = {{eng}},
publisher = {{Hindawi Limited}},
series = {{Journal of Tropical Medicine}},
title = {{How should antibodies against P. falciparum merozoite antigens be measured?}},
url = {{https://lup.lub.lu.se/search/files/3975603/8726831}},
doi = {{10.1155/2013/493834}},
year = {{2013}},
}