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Genome-wide Scan Identifies Role for AOX1 in Prostate Cancer Survival

Li, Weiqiang ; Middha, Mridu ; Bicak, Mesude ; Sjoberg, Daniel D. ; Vertosick, Emily ; Dahlin, Anders LU ; Häggström, Christel ; Hallmans, Göran ; Rönn, Ann Charlotte and Stattin, Pär , et al. (2018) In European Urology 74(6). p.710-719
Abstract

We performed genome-wide association studies and found single nucleotide polymorphisms (SNPs) at seven independent loci associated with prostate-cancer-specific survival time. Two SNPs replicated in an independent cohort. The SNP rs73055188 at AOX1 is associated with AOX1 gene expression level, which is correlated with biochemical recurrence.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
AOX1, Expression quantitative trait locus, Genome-wide association study, Prostate cancer, Survival analysis
in
European Urology
volume
74
issue
6
pages
710 - 719
publisher
Elsevier
external identifiers
  • scopus:85049454744
  • pmid:30289108
ISSN
0302-2838
DOI
10.1016/j.eururo.2018.06.021
language
English
LU publication?
yes
id
8738fe3a-aa6e-4aee-a5c0-5e4b81155eb4
date added to LUP
2018-07-26 10:19:54
date last changed
2024-04-15 09:33:19
@article{8738fe3a-aa6e-4aee-a5c0-5e4b81155eb4,
  abstract     = {{<p>We performed genome-wide association studies and found single nucleotide polymorphisms (SNPs) at seven independent loci associated with prostate-cancer-specific survival time. Two SNPs replicated in an independent cohort. The SNP rs73055188 at AOX1 is associated with AOX1 gene expression level, which is correlated with biochemical recurrence.</p>}},
  author       = {{Li, Weiqiang and Middha, Mridu and Bicak, Mesude and Sjoberg, Daniel D. and Vertosick, Emily and Dahlin, Anders and Häggström, Christel and Hallmans, Göran and Rönn, Ann Charlotte and Stattin, Pär and Melander, Olle and Ulmert, David and Lilja, Hans and Klein, Robert J.}},
  issn         = {{0302-2838}},
  keywords     = {{AOX1; Expression quantitative trait locus; Genome-wide association study; Prostate cancer; Survival analysis}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{6}},
  pages        = {{710--719}},
  publisher    = {{Elsevier}},
  series       = {{European Urology}},
  title        = {{Genome-wide Scan Identifies Role for AOX1 in Prostate Cancer Survival}},
  url          = {{http://dx.doi.org/10.1016/j.eururo.2018.06.021}},
  doi          = {{10.1016/j.eururo.2018.06.021}},
  volume       = {{74}},
  year         = {{2018}},
}