Urinary Tract Infection Molecular Mechanisms and Clinical Translation.
(2016) In Pathogens 5(1).- Abstract
- Rapid developments in infection biology create new and exciting options for individualized diagnostics and therapy. Such new practices are needed to improve patient survival and reduce morbidity. Molecular determinants of host resistance to infection are being characterized, making it possible to identify susceptible individuals and to predict their risk for future morbidity. Immunotherapy is emerging as a new strategy to treat infections worldwide and controlled boosting of the host immune defense represents an important therapeutic alternative to antibiotics. In proof of concept studies, we have demonstrated that this approach is feasible. The long-term goal is not just to remove the pathogens but to also develop technologies that... (More)
- Rapid developments in infection biology create new and exciting options for individualized diagnostics and therapy. Such new practices are needed to improve patient survival and reduce morbidity. Molecular determinants of host resistance to infection are being characterized, making it possible to identify susceptible individuals and to predict their risk for future morbidity. Immunotherapy is emerging as a new strategy to treat infections worldwide and controlled boosting of the host immune defense represents an important therapeutic alternative to antibiotics. In proof of concept studies, we have demonstrated that this approach is feasible. The long-term goal is not just to remove the pathogens but to also develop technologies that restore resistance to infection in disease-prone patients and devise personalized therapeutic interventions. Here, we discuss some approaches to reaching these goals, in patients with urinary tract infection (UTI). We describe critical host signaling pathways that define symptoms and pathology and the genetic control of innate immune responses that balance protection against tissue damage. For some of these genes, human relevance has been documented in clinical studies, identifying them as potential targets for immune-modulatory therapies, as a complement to antibiotics. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8857091
- author
- Godaly, Gabriela LU ; Ambite, Ines LU ; Puthia, Manoj LU ; Nadeem, Aftab LU ; Ho, James ; Nagy, Károly LU ; Huang, Yujing LU ; Rydström, Gustav LU and Svanborg, Catharina LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pathogens
- volume
- 5
- issue
- 1
- publisher
- MDPI AG
- external identifiers
-
- pmid:26927188
- wos:000373680700017
- pmid:26927188
- scopus:85029744866
- ISSN
- 2076-0817
- DOI
- 10.3390/pathogens5010024
- language
- English
- LU publication?
- yes
- id
- 64539a18-de0a-4c3e-97db-5553d66233b0 (old id 8857091)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26927188?dopt=Abstract
- date added to LUP
- 2016-04-01 15:04:35
- date last changed
- 2023-09-03 23:03:24
@article{64539a18-de0a-4c3e-97db-5553d66233b0, abstract = {{Rapid developments in infection biology create new and exciting options for individualized diagnostics and therapy. Such new practices are needed to improve patient survival and reduce morbidity. Molecular determinants of host resistance to infection are being characterized, making it possible to identify susceptible individuals and to predict their risk for future morbidity. Immunotherapy is emerging as a new strategy to treat infections worldwide and controlled boosting of the host immune defense represents an important therapeutic alternative to antibiotics. In proof of concept studies, we have demonstrated that this approach is feasible. The long-term goal is not just to remove the pathogens but to also develop technologies that restore resistance to infection in disease-prone patients and devise personalized therapeutic interventions. Here, we discuss some approaches to reaching these goals, in patients with urinary tract infection (UTI). We describe critical host signaling pathways that define symptoms and pathology and the genetic control of innate immune responses that balance protection against tissue damage. For some of these genes, human relevance has been documented in clinical studies, identifying them as potential targets for immune-modulatory therapies, as a complement to antibiotics.}}, author = {{Godaly, Gabriela and Ambite, Ines and Puthia, Manoj and Nadeem, Aftab and Ho, James and Nagy, Károly and Huang, Yujing and Rydström, Gustav and Svanborg, Catharina}}, issn = {{2076-0817}}, language = {{eng}}, number = {{1}}, publisher = {{MDPI AG}}, series = {{Pathogens}}, title = {{Urinary Tract Infection Molecular Mechanisms and Clinical Translation.}}, url = {{http://dx.doi.org/10.3390/pathogens5010024}}, doi = {{10.3390/pathogens5010024}}, volume = {{5}}, year = {{2016}}, }