Fecundability according to male serum inhibin B - a prospective study among first pregnancy planners
(2005) In Human Reproduction 20(10). p.2909-2915- Abstract
- BACKGROUND: New biological markers of male fecundity are needed for use in large-scale epidemiological studies. We studied the association between male inhibin B and fecundability. METHODS: Four hundred and thirty Danish couples without previous reproductive experience were followed from termination of contraception until pregnancy or for a maximum of six menstrual cycles. At enrolment we obtained semen samples (n = 418) and blood samples to measure reproductive hormones, including inhibin B (n = 343). RESULTS: The fecundability odds ratio for an increment of male inhibin B by 1 log pg/ml was 1.428 (95% confidence interval 1.022-1.994), adjusted for factors influencing the crude estimate. Only inhibin B values below 100 pg/ml were strongly... (More)
- BACKGROUND: New biological markers of male fecundity are needed for use in large-scale epidemiological studies. We studied the association between male inhibin B and fecundability. METHODS: Four hundred and thirty Danish couples without previous reproductive experience were followed from termination of contraception until pregnancy or for a maximum of six menstrual cycles. At enrolment we obtained semen samples (n = 418) and blood samples to measure reproductive hormones, including inhibin B (n = 343). RESULTS: The fecundability odds ratio for an increment of male inhibin B by 1 log pg/ml was 1.428 (95% confidence interval 1.022-1.994), adjusted for factors influencing the crude estimate. Only inhibin B values below 100 pg/ml were strongly related to fecundability. We designed a receiver operating characteristic curve based on the 29 males with serum inhibin B <= 100 pg/ml. The area under the curve (AUC) for inhibin B was 0.787 and the corresponding AUCs for sperm density and FSH were 0.913 and 0.800, respectively. CONCLUSION: Serum inhibin B may be a reliable marker of male fecundity for epidemiological research and may have some advantages over sperm density. Our findings do not support the replacement of sperm density by male inhibin B when obtaining sperm data is an option. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/891472
- author
- Mabeck, LM ; Jensen, MS ; Toft, G ; Thulstrup, M ; Andersson, M ; Jensen, TK ; Giwercman, Aleksander LU ; Olsen, J and Bonde, JP
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- inhibins, fertility, male reproduction, sperm density, time to pregnancy
- in
- Human Reproduction
- volume
- 20
- issue
- 10
- pages
- 2909 - 2915
- publisher
- Oxford University Press
- external identifiers
-
- pmid:16024538
- wos:000232427600036
- scopus:27144546958
- ISSN
- 0268-1161
- DOI
- 10.1093/humrep/dei141
- language
- English
- LU publication?
- yes
- id
- f044bf19-2ea7-4b28-8187-b4e42d03e15d (old id 891472)
- date added to LUP
- 2016-04-01 12:00:59
- date last changed
- 2022-01-26 21:34:04
@article{f044bf19-2ea7-4b28-8187-b4e42d03e15d, abstract = {{BACKGROUND: New biological markers of male fecundity are needed for use in large-scale epidemiological studies. We studied the association between male inhibin B and fecundability. METHODS: Four hundred and thirty Danish couples without previous reproductive experience were followed from termination of contraception until pregnancy or for a maximum of six menstrual cycles. At enrolment we obtained semen samples (n = 418) and blood samples to measure reproductive hormones, including inhibin B (n = 343). RESULTS: The fecundability odds ratio for an increment of male inhibin B by 1 log pg/ml was 1.428 (95% confidence interval 1.022-1.994), adjusted for factors influencing the crude estimate. Only inhibin B values below 100 pg/ml were strongly related to fecundability. We designed a receiver operating characteristic curve based on the 29 males with serum inhibin B <= 100 pg/ml. The area under the curve (AUC) for inhibin B was 0.787 and the corresponding AUCs for sperm density and FSH were 0.913 and 0.800, respectively. CONCLUSION: Serum inhibin B may be a reliable marker of male fecundity for epidemiological research and may have some advantages over sperm density. Our findings do not support the replacement of sperm density by male inhibin B when obtaining sperm data is an option.}}, author = {{Mabeck, LM and Jensen, MS and Toft, G and Thulstrup, M and Andersson, M and Jensen, TK and Giwercman, Aleksander and Olsen, J and Bonde, JP}}, issn = {{0268-1161}}, keywords = {{inhibins; fertility; male reproduction; sperm density; time to pregnancy}}, language = {{eng}}, number = {{10}}, pages = {{2909--2915}}, publisher = {{Oxford University Press}}, series = {{Human Reproduction}}, title = {{Fecundability according to male serum inhibin B - a prospective study among first pregnancy planners}}, url = {{http://dx.doi.org/10.1093/humrep/dei141}}, doi = {{10.1093/humrep/dei141}}, volume = {{20}}, year = {{2005}}, }