Interaction with the host : the role of fibronectin and extracellular matrix proteins in the adhesion of Gram-negative bacteria
Vaca, Diana J ; Thibau, Arno ; Schütz, Monika ; Kraiczy, Peter ; Happonen, Lotta LU ; Malmström, Johan LU
and Kempf, Volkhard A J
(2020)
In Medical microbiology and immunology
209(3).
p.277-299
- Abstract
The capacity of pathogenic microorganisms to adhere to host cells and avoid clearance by the host immune system is the initial and most decisive step leading to infections. Bacteria have developed different strategies to attach to diverse host surface structures. One important strategy is the adhesion to extracellular matrix (ECM) proteins (e.g., collagen, fibronectin, laminin) that are highly abundant in connective tissue and basement membranes. Gram-negative bacteria express variable outer membrane proteins (adhesins) to attach to the host and to initiate the process of infection. Understanding the underlying molecular mechanisms of bacterial adhesion is a prerequisite for targeting this interaction by "anti-ligands" to prevent... (More)
The capacity of pathogenic microorganisms to adhere to host cells and avoid clearance by the host immune system is the initial and most decisive step leading to infections. Bacteria have developed different strategies to attach to diverse host surface structures. One important strategy is the adhesion to extracellular matrix (ECM) proteins (e.g., collagen, fibronectin, laminin) that are highly abundant in connective tissue and basement membranes. Gram-negative bacteria express variable outer membrane proteins (adhesins) to attach to the host and to initiate the process of infection. Understanding the underlying molecular mechanisms of bacterial adhesion is a prerequisite for targeting this interaction by "anti-ligands" to prevent colonization or infection of the host. Future development of such "anti-ligands" (specifically interfering with bacteria-host matrix interactions) might result in the development of a new class of anti-infective drugs for the therapy of infections caused by multidrug-resistant Gram-negative bacteria. This review summarizes our current knowledge about the manifold interactions of adhesins expressed by Gram-negative bacteria with ECM proteins and the use of this information for the generation of novel therapeutic antivirulence strategies.
(Less)
- author
- Vaca, Diana J
; Thibau, Arno
; Schütz, Monika
; Kraiczy, Peter
; Happonen, Lotta
LU
; Malmström, Johan
LU
and Kempf, Volkhard A J
- organization
- publishing date
- 2020-06
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Medical microbiology and immunology
- volume
- 209
- issue
- 3
- pages
- 23 pages
- publisher
- Springer
- external identifiers
-
- scopus:85075886713
- pmid:31784893
- ISSN
- 0300-8584
- DOI
- 10.1007/s00430-019-00644-3
- language
- English
- LU publication?
- yes
- id
- 8959b074-fc1a-477d-a098-c51b2ca514e8
- date added to LUP
- 2019-12-05 08:13:47
- date last changed
- 2024-06-27 09:07:30
@article{8959b074-fc1a-477d-a098-c51b2ca514e8,
abstract = {{<p>The capacity of pathogenic microorganisms to adhere to host cells and avoid clearance by the host immune system is the initial and most decisive step leading to infections. Bacteria have developed different strategies to attach to diverse host surface structures. One important strategy is the adhesion to extracellular matrix (ECM) proteins (e.g., collagen, fibronectin, laminin) that are highly abundant in connective tissue and basement membranes. Gram-negative bacteria express variable outer membrane proteins (adhesins) to attach to the host and to initiate the process of infection. Understanding the underlying molecular mechanisms of bacterial adhesion is a prerequisite for targeting this interaction by "anti-ligands" to prevent colonization or infection of the host. Future development of such "anti-ligands" (specifically interfering with bacteria-host matrix interactions) might result in the development of a new class of anti-infective drugs for the therapy of infections caused by multidrug-resistant Gram-negative bacteria. This review summarizes our current knowledge about the manifold interactions of adhesins expressed by Gram-negative bacteria with ECM proteins and the use of this information for the generation of novel therapeutic antivirulence strategies.</p>}},
author = {{Vaca, Diana J and Thibau, Arno and Schütz, Monika and Kraiczy, Peter and Happonen, Lotta and Malmström, Johan and Kempf, Volkhard A J}},
issn = {{0300-8584}},
language = {{eng}},
number = {{3}},
pages = {{277--299}},
publisher = {{Springer}},
series = {{Medical microbiology and immunology}},
title = {{Interaction with the host : the role of fibronectin and extracellular matrix proteins in the adhesion of Gram-negative bacteria}},
url = {{http://dx.doi.org/10.1007/s00430-019-00644-3}},
doi = {{10.1007/s00430-019-00644-3}},
volume = {{209}},
year = {{2020}},
}