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Effect of inhaling cymbopogon martinii essential oil and geraniol on serum biochemistry parameters and oxidative stress in rats

Andrade, Bruna Fernanda Murbach Teles ; Braga, Camila Pereira ; Dos Santos, Klinsmann Carolo LU ; Barbosa, Lidiane Nunes ; Rall, Vera Lúcia Mores ; Sforcin, José Maurício ; Fernandes, Ana Angélica Henrique and Fernandes Júnior, Ary (2014) In Biochemistry Research International 2014.
Abstract

The effects of the inhalation of Cymbopogon martinii essential oil (EO) and geraniol on Wistar rats were evaluated for biochemical parameters and hepatic oxidative stress. Wistar rats were divided into three groups n = 8: G1 was control group, treated with saline solution; G2 received geraniol; and G3 received C. martinii EO by inhalation during 30 days. No significant differences were observed in glycemia and triacylglycerol levels; G2 and G3 decreased P < 0.05 total cholesterol level. There were no differences in serum protein, urea, aspartate aminotransferase activity, and total hepatic protein. Creatinine levels increased in G2 but decreased in G3. Alanine aminotransferase activity and lipid hydroperoxide were higher in G2 than... (More)

The effects of the inhalation of Cymbopogon martinii essential oil (EO) and geraniol on Wistar rats were evaluated for biochemical parameters and hepatic oxidative stress. Wistar rats were divided into three groups n = 8: G1 was control group, treated with saline solution; G2 received geraniol; and G3 received C. martinii EO by inhalation during 30 days. No significant differences were observed in glycemia and triacylglycerol levels; G2 and G3 decreased P < 0.05 total cholesterol level. There were no differences in serum protein, urea, aspartate aminotransferase activity, and total hepatic protein. Creatinine levels increased in G2 but decreased in G3. Alanine aminotransferase activity and lipid hydroperoxide were higher in G2 than in G3. Catalase and superoxide dismutase activities were higher in G3. C. martinii EO and geraniol increased glutathione peroxidase. Oxidative stress caused by geraniol may have triggered some degree of hepatic toxicity, as verified by the increase in serum creatinine and alanine aminotransferase. Therefore, the beneficial effects of EO on oxidative stress can prevent the toxicity in the liver. This proves possible interactions between geraniol and numerous chemical compounds present in C. martinii EO.

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publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemistry Research International
volume
2014
article number
493183
publisher
Hindawi Limited
external identifiers
  • scopus:84919781999
ISSN
2090-2247
DOI
10.1155/2014/493183
language
English
LU publication?
no
id
896bb760-ac26-4bab-a7a9-ae9d9e325734
date added to LUP
2019-03-28 14:46:16
date last changed
2022-04-18 03:37:40
@article{896bb760-ac26-4bab-a7a9-ae9d9e325734,
  abstract     = {{<p>The effects of the inhalation of Cymbopogon martinii essential oil (EO) and geraniol on Wistar rats were evaluated for biochemical parameters and hepatic oxidative stress. Wistar rats were divided into three groups n = 8: G1 was control group, treated with saline solution; G2 received geraniol; and G3 received C. martinii EO by inhalation during 30 days. No significant differences were observed in glycemia and triacylglycerol levels; G2 and G3 decreased P &lt; 0.05 total cholesterol level. There were no differences in serum protein, urea, aspartate aminotransferase activity, and total hepatic protein. Creatinine levels increased in G2 but decreased in G3. Alanine aminotransferase activity and lipid hydroperoxide were higher in G2 than in G3. Catalase and superoxide dismutase activities were higher in G3. C. martinii EO and geraniol increased glutathione peroxidase. Oxidative stress caused by geraniol may have triggered some degree of hepatic toxicity, as verified by the increase in serum creatinine and alanine aminotransferase. Therefore, the beneficial effects of EO on oxidative stress can prevent the toxicity in the liver. This proves possible interactions between geraniol and numerous chemical compounds present in C. martinii EO.</p>}},
  author       = {{Andrade, Bruna Fernanda Murbach Teles and Braga, Camila Pereira and Dos Santos, Klinsmann Carolo and Barbosa, Lidiane Nunes and Rall, Vera Lúcia Mores and Sforcin, José Maurício and Fernandes, Ana Angélica Henrique and Fernandes Júnior, Ary}},
  issn         = {{2090-2247}},
  language     = {{eng}},
  month        = {{12}},
  publisher    = {{Hindawi Limited}},
  series       = {{Biochemistry Research International}},
  title        = {{Effect of inhaling cymbopogon martinii essential oil and geraniol on serum biochemistry parameters and oxidative stress in rats}},
  url          = {{http://dx.doi.org/10.1155/2014/493183}},
  doi          = {{10.1155/2014/493183}},
  volume       = {{2014}},
  year         = {{2014}},
}