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Escalated dose for non-small-cell lung cancer with accelerated hypofractionated three-dimensional conformal radiation therapy

Thirion, P ; Holmberg, Ola LU ; Collins, CD ; O'Shea, C ; Moriarty, M ; Pomeroy, M ; O'Sullivan, C ; Buckney, S and Armstrong, J (2004) In Radiotherapy and Oncology 71(2). p.163-166
Abstract
Background and Purpose: To prospectively assess the feasibility and efficacy of a hypofractionated accelerated radiotherapy regimen (72 Gy in 24 daily fractions, 3Gy per fraction) in patients (pts) with non-resectable non-small-cell lung cancer (NSCLC). Material and Methods: We included 25 Ins with a histologically or cytologically proven NSCLC, with KPS greater than or equal to 70 and less than or equal to 10% weight loss over prior three months, and with tumour stage I/II medically inoperable (9 pts) or non-resectable stage III a/b without pleural effusion (16 pts). Eleven pts received induction chemotherapy. No more than 30% of the combined lung volume could receive more than 25 Gy and the maximal biological effective dose to the spinal... (More)
Background and Purpose: To prospectively assess the feasibility and efficacy of a hypofractionated accelerated radiotherapy regimen (72 Gy in 24 daily fractions, 3Gy per fraction) in patients (pts) with non-resectable non-small-cell lung cancer (NSCLC). Material and Methods: We included 25 Ins with a histologically or cytologically proven NSCLC, with KPS greater than or equal to 70 and less than or equal to 10% weight loss over prior three months, and with tumour stage I/II medically inoperable (9 pts) or non-resectable stage III a/b without pleural effusion (16 pts). Eleven pts received induction chemotherapy. No more than 30% of the combined lung volume could receive more than 25 Gy and the maximal biological effective dose to the spinal cord was maintained below 44 Gy. Results: No grade-4 acute toxicity event was reported. Two pts had a treatment break because of grade-3 acute oesophagitis. Twenty-two pts were evaluable for long-term toxicity (median follow-up = 9.7 months, range 4 to 30.2 months). There were 4 Grade-1 pulmonary and 2 Grade-1 oesophageal long-term toxicity events. Twenty-two pts were evaluable for tumour response with 7 complete and 8 partial responses, 5 stable diseases and 2 progressive diseases. The actuarial 1-year overall and thoracic-progression-free survival rates were 68% and 72% respectively. Conclusions: This study demonstrates the feasibility of the experimental radiotherapy schedule, however more data are needed to confirm its efficacy. (C) 2003 Published by Elsevier Ireland Ltd. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
non-small-cell lung cancer, three-dimensional conformal radiation, therapy, acceleration, dose escalation, hypofractionation
in
Radiotherapy and Oncology
volume
71
issue
2
pages
163 - 166
publisher
Elsevier
external identifiers
  • wos:000221371300006
  • pmid:15110449
  • scopus:1942542250
  • pmid:15110449
ISSN
1879-0887
DOI
10.1016/j.radonc.2003.09.006
language
English
LU publication?
yes
id
d71b1675-3fb9-421b-b010-9a59c6491625 (old id 898995)
date added to LUP
2016-04-01 12:36:37
date last changed
2022-01-27 07:28:20
@article{d71b1675-3fb9-421b-b010-9a59c6491625,
  abstract     = {{Background and Purpose: To prospectively assess the feasibility and efficacy of a hypofractionated accelerated radiotherapy regimen (72 Gy in 24 daily fractions, 3Gy per fraction) in patients (pts) with non-resectable non-small-cell lung cancer (NSCLC). Material and Methods: We included 25 Ins with a histologically or cytologically proven NSCLC, with KPS greater than or equal to 70 and less than or equal to 10% weight loss over prior three months, and with tumour stage I/II medically inoperable (9 pts) or non-resectable stage III a/b without pleural effusion (16 pts). Eleven pts received induction chemotherapy. No more than 30% of the combined lung volume could receive more than 25 Gy and the maximal biological effective dose to the spinal cord was maintained below 44 Gy. Results: No grade-4 acute toxicity event was reported. Two pts had a treatment break because of grade-3 acute oesophagitis. Twenty-two pts were evaluable for long-term toxicity (median follow-up = 9.7 months, range 4 to 30.2 months). There were 4 Grade-1 pulmonary and 2 Grade-1 oesophageal long-term toxicity events. Twenty-two pts were evaluable for tumour response with 7 complete and 8 partial responses, 5 stable diseases and 2 progressive diseases. The actuarial 1-year overall and thoracic-progression-free survival rates were 68% and 72% respectively. Conclusions: This study demonstrates the feasibility of the experimental radiotherapy schedule, however more data are needed to confirm its efficacy. (C) 2003 Published by Elsevier Ireland Ltd.}},
  author       = {{Thirion, P and Holmberg, Ola and Collins, CD and O'Shea, C and Moriarty, M and Pomeroy, M and O'Sullivan, C and Buckney, S and Armstrong, J}},
  issn         = {{1879-0887}},
  keywords     = {{non-small-cell lung cancer; three-dimensional conformal radiation; therapy; acceleration; dose escalation; hypofractionation}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{163--166}},
  publisher    = {{Elsevier}},
  series       = {{Radiotherapy and Oncology}},
  title        = {{Escalated dose for non-small-cell lung cancer with accelerated hypofractionated three-dimensional conformal radiation therapy}},
  url          = {{http://dx.doi.org/10.1016/j.radonc.2003.09.006}},
  doi          = {{10.1016/j.radonc.2003.09.006}},
  volume       = {{71}},
  year         = {{2004}},
}