Molecular imaging with endogenous substances
Golman, Klaes LU ; Ardenaer-Larsen, JH ; Petersson, JS ; Månsson, Sven LU
and Leunbach, I
(2003)
In Proceedings of the National Academy of Sciences
100(18).
p.10435-10439
- Abstract
- Dynamic nuclear polarization has enabled hyperpolarization of nuclei such as C-13 and N-15 in endogenous substances. The resulting high nuclear polarization makes it possible to perform subsecond C-13 MRI. By using the dynamic nuclear polarization hyperpolarization technique, 10% polarization was obtained in an aqueous solution of 100 mM C-13-labeled urea, ready for injection. The in vivo T, relaxation time of C-13 in the urea solution was determined to 20 +/- 2 s. Due to the long relaxation time, it is possible to use the hyperpolarized substance for medical imaging. A series of high-resolution (approximate to1-mm) magnetic resonance images were acquired, each with a scan time of 240 ms, 0-5 s after an i.v. injection of the hyperpolarized... (More)
- Dynamic nuclear polarization has enabled hyperpolarization of nuclei such as C-13 and N-15 in endogenous substances. The resulting high nuclear polarization makes it possible to perform subsecond C-13 MRI. By using the dynamic nuclear polarization hyperpolarization technique, 10% polarization was obtained in an aqueous solution of 100 mM C-13-labeled urea, ready for injection. The in vivo T, relaxation time of C-13 in the urea solution was determined to 20 +/- 2 s. Due to the long relaxation time, it is possible to use the hyperpolarized substance for medical imaging. A series of high-resolution (approximate to1-mm) magnetic resonance images were acquired, each with a scan time of 240 ms, 0-5 s after an i.v. injection of the hyperpolarized aqueous [C-13]urea solution in a rat. The results show that it is possible to perform C-13 angiography with a signal-to-noise ratio of approximate to275 in approximate to0.25 s. Perfusion studies with endogenous substances may allow higher spatial and/or temporal resolution than is possible with current proton imaging techniques. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/899989
- author
- Golman, Klaes
LU
; Ardenaer-Larsen, JH
; Petersson, JS
; Månsson, Sven
LU
and Leunbach, I
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Proceedings of the National Academy of Sciences
- volume
- 100
- issue
- 18
- pages
- 10435 - 10439
- publisher
- National Academy of Sciences
- external identifiers
-
- wos:000185119300055
- scopus:0041836259
- pmid:12930896
- ISSN
- 1091-6490
- DOI
- 10.1073/pnas.1733836100
- language
- English
- LU publication?
- yes
- id
- 7739d0e5-8ea0-4c74-ae22-886fc8fc0ee9 (old id 899989)
- date added to LUP
- 2016-04-01 12:15:11
- date last changed
- 2022-02-11 04:25:54
@article{7739d0e5-8ea0-4c74-ae22-886fc8fc0ee9,
abstract = {{Dynamic nuclear polarization has enabled hyperpolarization of nuclei such as C-13 and N-15 in endogenous substances. The resulting high nuclear polarization makes it possible to perform subsecond C-13 MRI. By using the dynamic nuclear polarization hyperpolarization technique, 10% polarization was obtained in an aqueous solution of 100 mM C-13-labeled urea, ready for injection. The in vivo T, relaxation time of C-13 in the urea solution was determined to 20 +/- 2 s. Due to the long relaxation time, it is possible to use the hyperpolarized substance for medical imaging. A series of high-resolution (approximate to1-mm) magnetic resonance images were acquired, each with a scan time of 240 ms, 0-5 s after an i.v. injection of the hyperpolarized aqueous [C-13]urea solution in a rat. The results show that it is possible to perform C-13 angiography with a signal-to-noise ratio of approximate to275 in approximate to0.25 s. Perfusion studies with endogenous substances may allow higher spatial and/or temporal resolution than is possible with current proton imaging techniques.}},
author = {{Golman, Klaes and Ardenaer-Larsen, JH and Petersson, JS and Månsson, Sven and Leunbach, I}},
issn = {{1091-6490}},
language = {{eng}},
number = {{18}},
pages = {{10435--10439}},
publisher = {{National Academy of Sciences}},
series = {{Proceedings of the National Academy of Sciences}},
title = {{Molecular imaging with endogenous substances}},
url = {{http://dx.doi.org/10.1073/pnas.1733836100}},
doi = {{10.1073/pnas.1733836100}},
volume = {{100}},
year = {{2003}},
}