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Cutting Edge : Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1

de Pooter, Renée F. ; Dias, Sheila ; Chowdhury, Munmun ; Bartom, Elisabeth T. ; Okoreeh, Michael K. ; Sigvardsson, Mikael LU and Kee, Barbara L. (2019) In Journal of immunology 202(10). p.2837-2842
Abstract

Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acute lymphoblastic leukemia and is required for HSC specification, erythropoiesis, and megakaryopoiesis, is a negative regulator of murine lymphoid specification. We demonstrate that Tal1 limits the expression of multiple E2A target genes in HSCs and controls the balance of myeloid versus T lymphocyte differentiation potential in... (More)

Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acute lymphoblastic leukemia and is required for HSC specification, erythropoiesis, and megakaryopoiesis, is a negative regulator of murine lymphoid specification. We demonstrate that Tal1 limits the expression of multiple E2A target genes in HSCs and controls the balance of myeloid versus T lymphocyte differentiation potential in lymphomyeloid-primed progenitors. Our data provide insight into the mechanisms controlling lymphocyte specification and may reveal a basis for the unique functions of Tal1 and Lyl1 in T acute lymphoblastic leukemia.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of immunology
volume
202
issue
10
pages
6 pages
publisher
American Association of Immunologists
external identifiers
  • pmid:30962294
  • scopus:85065678622
ISSN
1550-6606
DOI
10.4049/jimmunol.1801220
language
English
LU publication?
yes
id
8a6aff71-e140-4efe-96d6-363230f32711
date added to LUP
2019-05-28 10:22:48
date last changed
2024-05-28 13:36:20
@article{8a6aff71-e140-4efe-96d6-363230f32711,
  abstract     = {{<p>Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acute lymphoblastic leukemia and is required for HSC specification, erythropoiesis, and megakaryopoiesis, is a negative regulator of murine lymphoid specification. We demonstrate that Tal1 limits the expression of multiple E2A target genes in HSCs and controls the balance of myeloid versus T lymphocyte differentiation potential in lymphomyeloid-primed progenitors. Our data provide insight into the mechanisms controlling lymphocyte specification and may reveal a basis for the unique functions of Tal1 and Lyl1 in T acute lymphoblastic leukemia.</p>}},
  author       = {{de Pooter, Renée F. and Dias, Sheila and Chowdhury, Munmun and Bartom, Elisabeth T. and Okoreeh, Michael K. and Sigvardsson, Mikael and Kee, Barbara L.}},
  issn         = {{1550-6606}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{2837--2842}},
  publisher    = {{American Association of Immunologists}},
  series       = {{Journal of immunology}},
  title        = {{Cutting Edge : Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1}},
  url          = {{http://dx.doi.org/10.4049/jimmunol.1801220}},
  doi          = {{10.4049/jimmunol.1801220}},
  volume       = {{202}},
  year         = {{2019}},
}