Cell density dependent release of hepatic lipase in cultured hepatocytes
(1989) In Hormone and Metabolic Research 21(1). p.4-7- Abstract
- Cultured rat hepatocytes release the enzyme hepatic lipase. In this study we investigated the effect of cell density on this metabolic function under a variety of experimental conditions. The release of hepatic lipase from cultured rat hepatocytes exhibits a cell-density dependence, the secretion per mg cell protein being increased with increasing cell density. When cell density dependence was taken into consideration no significant effect of insulin on the release of hepatic lipase from cultured hepatocytes was observed, whereas glucagon suppressed the release. Glucose stimulating the release of the enzyme, especially in cultures with high cell density.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8bd92e94-6259-4862-9ddf-e32da52f0cbd
- author
- Jensen, Elmo ; Florén, Claes-Henrik LU ; Hansson, Per ; Nilsson-Ehle, Peter LU and Nilsson, Åke LU
- publishing date
- 1989-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Hormone and Metabolic Research
- volume
- 21
- issue
- 1
- pages
- 4 pages
- publisher
- Georg Thieme Verlag
- external identifiers
-
- pmid:2647607
- scopus:0024596519
- ISSN
- 1439-4286
- DOI
- 10.1055/s-2007-1009136
- language
- English
- LU publication?
- no
- id
- 8bd92e94-6259-4862-9ddf-e32da52f0cbd
- date added to LUP
- 2019-05-30 16:33:36
- date last changed
- 2021-12-07 04:00:33
@article{8bd92e94-6259-4862-9ddf-e32da52f0cbd, abstract = {{Cultured rat hepatocytes release the enzyme hepatic lipase. In this study we investigated the effect of cell density on this metabolic function under a variety of experimental conditions. The release of hepatic lipase from cultured rat hepatocytes exhibits a cell-density dependence, the secretion per mg cell protein being increased with increasing cell density. When cell density dependence was taken into consideration no significant effect of insulin on the release of hepatic lipase from cultured hepatocytes was observed, whereas glucagon suppressed the release. Glucose stimulating the release of the enzyme, especially in cultures with high cell density.}}, author = {{Jensen, Elmo and Florén, Claes-Henrik and Hansson, Per and Nilsson-Ehle, Peter and Nilsson, Åke}}, issn = {{1439-4286}}, language = {{eng}}, month = {{01}}, number = {{1}}, pages = {{4--7}}, publisher = {{Georg Thieme Verlag}}, series = {{Hormone and Metabolic Research}}, title = {{Cell density dependent release of hepatic lipase in cultured hepatocytes}}, url = {{http://dx.doi.org/10.1055/s-2007-1009136}}, doi = {{10.1055/s-2007-1009136}}, volume = {{21}}, year = {{1989}}, }