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Does Emerging Carbapenem Resistance in Acinetobacter baumannii Increase the Case Fatality Rate? : Systematic Review and Meta-Analysis

Boral, Jale LU orcid ; Pınarlık, Fatihan ; Ekinci, Güz ; Can, Füsun and Ergönül, Önder (2023) In Infectious Disease Reports 15(5). p.564-575
Abstract

BACKGROUND: In the era of rising carbapenem resistance, we aimed to investigate the change in mortality rate and positivity of carbapenemase genes in Acinetobacter baumannii.

METHODS: Preferred Reporting Items for Systematic Review (PRISMA) guidelines were adopted in this systematic review. Our literature search included the Cochrane Library, Pubmed, Scopus, Web of Science, Medline, Tubitak TR Dizin, and Harman databases for studies dating back from 2003 to 2023 reporting bloodstream A. baumannii infections in Türkiye. A simple linear regression model was used to determine the association between resistance, mortality, and time.

RESULTS: A total of 1717 studies were identified through a literature search, and 21 articles... (More)

BACKGROUND: In the era of rising carbapenem resistance, we aimed to investigate the change in mortality rate and positivity of carbapenemase genes in Acinetobacter baumannii.

METHODS: Preferred Reporting Items for Systematic Review (PRISMA) guidelines were adopted in this systematic review. Our literature search included the Cochrane Library, Pubmed, Scopus, Web of Science, Medline, Tubitak TR Dizin, and Harman databases for studies dating back from 2003 to 2023 reporting bloodstream A. baumannii infections in Türkiye. A simple linear regression model was used to determine the association between resistance, mortality, and time.

RESULTS: A total of 1717 studies were identified through a literature search, and 21 articles were selected based on the availability of the data regarding mortality and resistance rate (four articles) or the molecular epidemiology of carbapenem-resistant A. baumannii (17 articles) in Türkiye. From 2007 to 2018, the carbapenem resistance rate increased (p = 0.025). The OXA-23 and OXA-58 positivities were inversely correlated (p = 0.025).

CONCLUSIONS: Despite the emergence of carbapenem resistance, mortality did not increase in parallel, which may be due to improved medical advancements or the fitness cost of bacteria upon prolonged antimicrobial exposure. Therefore, we suggest further global research with the foresight to assess clonal relatedness that might affect the carbapenem resistance rate.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
Infectious Disease Reports
volume
15
issue
5
pages
564 - 575
publisher
Page Press
external identifiers
  • pmid:37888136
  • scopus:85175032951
ISSN
2036-7430
DOI
10.3390/idr15050055
language
English
LU publication?
no
id
8c2d1e1e-26c9-4ef2-bd07-53aafd8c738d
date added to LUP
2024-10-28 13:11:09
date last changed
2025-07-23 02:42:52
@article{8c2d1e1e-26c9-4ef2-bd07-53aafd8c738d,
  abstract     = {{<p>BACKGROUND: In the era of rising carbapenem resistance, we aimed to investigate the change in mortality rate and positivity of carbapenemase genes in Acinetobacter baumannii.</p><p>METHODS: Preferred Reporting Items for Systematic Review (PRISMA) guidelines were adopted in this systematic review. Our literature search included the Cochrane Library, Pubmed, Scopus, Web of Science, Medline, Tubitak TR Dizin, and Harman databases for studies dating back from 2003 to 2023 reporting bloodstream A. baumannii infections in Türkiye. A simple linear regression model was used to determine the association between resistance, mortality, and time.</p><p>RESULTS: A total of 1717 studies were identified through a literature search, and 21 articles were selected based on the availability of the data regarding mortality and resistance rate (four articles) or the molecular epidemiology of carbapenem-resistant A. baumannii (17 articles) in Türkiye. From 2007 to 2018, the carbapenem resistance rate increased (p = 0.025). The OXA-23 and OXA-58 positivities were inversely correlated (p = 0.025).</p><p>CONCLUSIONS: Despite the emergence of carbapenem resistance, mortality did not increase in parallel, which may be due to improved medical advancements or the fitness cost of bacteria upon prolonged antimicrobial exposure. Therefore, we suggest further global research with the foresight to assess clonal relatedness that might affect the carbapenem resistance rate.</p>}},
  author       = {{Boral, Jale and Pınarlık, Fatihan and Ekinci, Güz and Can, Füsun and Ergönül, Önder}},
  issn         = {{2036-7430}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{5}},
  pages        = {{564--575}},
  publisher    = {{Page Press}},
  series       = {{Infectious Disease Reports}},
  title        = {{Does Emerging Carbapenem Resistance in Acinetobacter baumannii Increase the Case Fatality Rate? : Systematic Review and Meta-Analysis}},
  url          = {{http://dx.doi.org/10.3390/idr15050055}},
  doi          = {{10.3390/idr15050055}},
  volume       = {{15}},
  year         = {{2023}},
}