Transposable elements in the mammalian embryo : pioneers surviving through stealth and service
(2016) In Genome Biology 17. p.1-17- Abstract
Transposable elements (TEs) are notable drivers of genetic innovation. Over evolutionary time, TE insertions can supply new promoter, enhancer, and insulator elements to protein-coding genes and establish novel, species-specific gene regulatory networks. Conversely, ongoing TE-driven insertional mutagenesis, nonhomologous recombination, and other potentially deleterious processes can cause sporadic disease by disrupting genome integrity or inducing abrupt gene expression changes. Here, we discuss recent evidence suggesting that TEs may contribute regulatory innovation to mammalian embryonic and pluripotent states as a means to ward off complete repression by their host genome.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8d7810d1-0bc1-46dd-9078-c837934874b4
- author
- Gerdes, Patricia
LU
; Richardson, Sandra R ; Mager, Dixie L and Faulkner, Geoffrey J
- publishing date
- 2016-05-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Cell Differentiation/genetics, DNA Transposable Elements, Embryonic Development/genetics, Endogenous Retroviruses/genetics, Gene Expression Regulation, Developmental, Humans
- in
- Genome Biology
- volume
- 17
- article number
- 100
- pages
- 1 - 17
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:27161170
- scopus:84971228919
- ISSN
- 1474-7596
- DOI
- 10.1186/s13059-016-0965-5
- language
- English
- LU publication?
- no
- id
- 8d7810d1-0bc1-46dd-9078-c837934874b4
- date added to LUP
- 2024-06-10 16:16:51
- date last changed
- 2024-06-12 03:06:28
@article{8d7810d1-0bc1-46dd-9078-c837934874b4, abstract = {{<p>Transposable elements (TEs) are notable drivers of genetic innovation. Over evolutionary time, TE insertions can supply new promoter, enhancer, and insulator elements to protein-coding genes and establish novel, species-specific gene regulatory networks. Conversely, ongoing TE-driven insertional mutagenesis, nonhomologous recombination, and other potentially deleterious processes can cause sporadic disease by disrupting genome integrity or inducing abrupt gene expression changes. Here, we discuss recent evidence suggesting that TEs may contribute regulatory innovation to mammalian embryonic and pluripotent states as a means to ward off complete repression by their host genome.</p>}}, author = {{Gerdes, Patricia and Richardson, Sandra R and Mager, Dixie L and Faulkner, Geoffrey J}}, issn = {{1474-7596}}, keywords = {{Animals; Cell Differentiation/genetics; DNA Transposable Elements; Embryonic Development/genetics; Endogenous Retroviruses/genetics; Gene Expression Regulation, Developmental; Humans}}, language = {{eng}}, month = {{05}}, pages = {{1--17}}, publisher = {{BioMed Central (BMC)}}, series = {{Genome Biology}}, title = {{Transposable elements in the mammalian embryo : pioneers surviving through stealth and service}}, url = {{http://dx.doi.org/10.1186/s13059-016-0965-5}}, doi = {{10.1186/s13059-016-0965-5}}, volume = {{17}}, year = {{2016}}, }