Visual outcome is similar in optic neuritis patients treated with oral and i.v. high-dose methylprednisolone: a retrospective study on 56 patients
(2018) In BMC Neurology 18.- Abstract
- BACKGROUND: To investigate visual recovery after treatment of acute optic neuritis (ON) with either oral or intravenous high-dose methylprednisolone, in order to establish the best route of administration.
METHODS: Retrospective analysis of patients treated with oral or intravenous high-dose (≥500 mg per day) methylprednisolone for acute ON of unknown or demyelinating etiology. Twenty-eight patients were included in each treatment group. Visual acuity was measured with the Snellen letter chart, color vision with Boström-Kugelberg pseudo-isochromatic plates, and visual field with a Humphrey Field Analyzer.
RESULTS: The treatment results were similar in the two groups at follow-up, with no significant difference in visual acuity (p =... (More) - BACKGROUND: To investigate visual recovery after treatment of acute optic neuritis (ON) with either oral or intravenous high-dose methylprednisolone, in order to establish the best route of administration.
METHODS: Retrospective analysis of patients treated with oral or intravenous high-dose (≥500 mg per day) methylprednisolone for acute ON of unknown or demyelinating etiology. Twenty-eight patients were included in each treatment group. Visual acuity was measured with the Snellen letter chart, color vision with Boström-Kugelberg pseudo-isochromatic plates, and visual field with a Humphrey Field Analyzer.
RESULTS: The treatment results were similar in the two groups at follow-up, with no significant difference in visual acuity (p = 0.54), color vision (p = 0.18), visual field mean deviation (p = 0.39) or the number of highly significantly depressed test points (p = 0.46).
CONCLUSIONS: The results show no clinical disadvantage of using oral high-dose corticosteroids compared to intravenous administration in the treatment of acute ON, which would facilitate the clinical management of these patients. (Less)
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https://lup.lub.lu.se/record/8e6264b2-411b-42f1-8bff-2b9656c4815a
- author
- Naumovska, Magdalena LU ; Sheikh, Rafi LU ; Bengtsson, Boel LU ; Malmsjö, Malin LU and Hammar, Björn LU
- organization
- publishing date
- 2018-09-30
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC Neurology
- volume
- 18
- article number
- 160
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85054055669
- pmid:30268104
- ISSN
- 1471-2377
- DOI
- 10.1186/s12883-018-1165-6
- language
- English
- LU publication?
- yes
- id
- 8e6264b2-411b-42f1-8bff-2b9656c4815a
- date added to LUP
- 2018-09-30 08:09:33
- date last changed
- 2022-05-03 06:22:26
@article{8e6264b2-411b-42f1-8bff-2b9656c4815a, abstract = {{BACKGROUND: To investigate visual recovery after treatment of acute optic neuritis (ON) with either oral or intravenous high-dose methylprednisolone, in order to establish the best route of administration.<br/>METHODS: Retrospective analysis of patients treated with oral or intravenous high-dose (≥500 mg per day) methylprednisolone for acute ON of unknown or demyelinating etiology. Twenty-eight patients were included in each treatment group. Visual acuity was measured with the Snellen letter chart, color vision with Boström-Kugelberg pseudo-isochromatic plates, and visual field with a Humphrey Field Analyzer.<br/>RESULTS: The treatment results were similar in the two groups at follow-up, with no significant difference in visual acuity (p = 0.54), color vision (p = 0.18), visual field mean deviation (p = 0.39) or the number of highly significantly depressed test points (p = 0.46).<br/>CONCLUSIONS: The results show no clinical disadvantage of using oral high-dose corticosteroids compared to intravenous administration in the treatment of acute ON, which would facilitate the clinical management of these patients.}}, author = {{Naumovska, Magdalena and Sheikh, Rafi and Bengtsson, Boel and Malmsjö, Malin and Hammar, Björn}}, issn = {{1471-2377}}, language = {{eng}}, month = {{09}}, publisher = {{BioMed Central (BMC)}}, series = {{BMC Neurology}}, title = {{Visual outcome is similar in optic neuritis patients treated with oral and i.v. high-dose methylprednisolone: a retrospective study on 56 patients}}, url = {{http://dx.doi.org/10.1186/s12883-018-1165-6}}, doi = {{10.1186/s12883-018-1165-6}}, volume = {{18}}, year = {{2018}}, }