Anti-phosphatidylserine antibody levels are low in multigravid pregnant women in a malaria-endemic area in Nigeria, and do not correlate with anti-VAR2CSA antibodies
(2023) In Frontiers in cellular and infection microbiology 13.- Abstract
Anemia is a common malaria-associated complication in pregnant women in endemic regions. Phosphatidylserine (PS) is exposed to the immune system during the massive destruction of red blood cells (RBCs) that accompany malaria, and antibodies against PS have been linked to anemia through destruction of uninfected RBCs. We determined levels of anti-PS IgG antibodies in pregnant women in Ibadan, Nigeria and correlated them to parameters of importance in development of anemia and immunity. Anti-PS correlated inversely with Packed Cell Volume (PCV), indicating that the antibodies could contribute to anemia. There was no correlation with anti-VAR2CSA IgG, haptoglobin or parasitemia, indicating that the modulation of anti-PS response is... (More)
Anemia is a common malaria-associated complication in pregnant women in endemic regions. Phosphatidylserine (PS) is exposed to the immune system during the massive destruction of red blood cells (RBCs) that accompany malaria, and antibodies against PS have been linked to anemia through destruction of uninfected RBCs. We determined levels of anti-PS IgG antibodies in pregnant women in Ibadan, Nigeria and correlated them to parameters of importance in development of anemia and immunity. Anti-PS correlated inversely with Packed Cell Volume (PCV), indicating that the antibodies could contribute to anemia. There was no correlation with anti-VAR2CSA IgG, haptoglobin or parasitemia, indicating that the modulation of anti-PS response is multifactorial in nature. Anti-PS levels were lowest in multigravidae compared to both primigravidae and secundigravidae and correlated inversely with age. In conclusion, lower levels of anti-PS in multigravidae could be beneficial in avoiding anemia.
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- author
- Fasanya, Adebimpe ; Mohammed, Nurat ; Saleh, Bandar Hasan LU ; Tijani, Muyideen Kolapo LU ; Teleka, Alexandra LU ; Quintana, Maria Del Pilar ; Hviid, Lars and Persson, Kristina E M LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Humans, Pregnancy, Female, Pregnant Women, Malaria, Falciparum, Nigeria/epidemiology, Phosphatidylserines, Malaria/complications, Anemia/complications, Immunoglobulin G, Plasmodium falciparum, Antigens, Protozoan, Antibodies, Protozoan
- in
- Frontiers in cellular and infection microbiology
- volume
- 13
- article number
- 1130186
- publisher
- Frontiers Media S. A.
- external identifiers
-
- scopus:85153487512
- pmid:37091678
- ISSN
- 2235-2988
- DOI
- 10.3389/fcimb.2023.1130186
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2023 Fasanya, Mohammed, Saleh, Tijani, Teleka, Quintana, Hviid and Persson.
- id
- 8f4d8b20-0f8f-4555-999d-1b5cf327e622
- date added to LUP
- 2023-05-23 13:06:51
- date last changed
- 2024-09-07 11:21:54
@article{8f4d8b20-0f8f-4555-999d-1b5cf327e622, abstract = {{<p>Anemia is a common malaria-associated complication in pregnant women in endemic regions. Phosphatidylserine (PS) is exposed to the immune system during the massive destruction of red blood cells (RBCs) that accompany malaria, and antibodies against PS have been linked to anemia through destruction of uninfected RBCs. We determined levels of anti-PS IgG antibodies in pregnant women in Ibadan, Nigeria and correlated them to parameters of importance in development of anemia and immunity. Anti-PS correlated inversely with Packed Cell Volume (PCV), indicating that the antibodies could contribute to anemia. There was no correlation with anti-VAR2CSA IgG, haptoglobin or parasitemia, indicating that the modulation of anti-PS response is multifactorial in nature. Anti-PS levels were lowest in multigravidae compared to both primigravidae and secundigravidae and correlated inversely with age. In conclusion, lower levels of anti-PS in multigravidae could be beneficial in avoiding anemia.</p>}}, author = {{Fasanya, Adebimpe and Mohammed, Nurat and Saleh, Bandar Hasan and Tijani, Muyideen Kolapo and Teleka, Alexandra and Quintana, Maria Del Pilar and Hviid, Lars and Persson, Kristina E M}}, issn = {{2235-2988}}, keywords = {{Humans; Pregnancy; Female; Pregnant Women; Malaria, Falciparum; Nigeria/epidemiology; Phosphatidylserines; Malaria/complications; Anemia/complications; Immunoglobulin G; Plasmodium falciparum; Antigens, Protozoan; Antibodies, Protozoan}}, language = {{eng}}, publisher = {{Frontiers Media S. A.}}, series = {{Frontiers in cellular and infection microbiology}}, title = {{Anti-phosphatidylserine antibody levels are low in multigravid pregnant women in a malaria-endemic area in Nigeria, and do not correlate with anti-VAR2CSA antibodies}}, url = {{http://dx.doi.org/10.3389/fcimb.2023.1130186}}, doi = {{10.3389/fcimb.2023.1130186}}, volume = {{13}}, year = {{2023}}, }