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Circulating anti-pericyte autoantibodies are present in Type 2 diabetic patients and are associated with non-proliferative retinopathy

Nayak, RC ; Agardh, Carl-David LU ; Kwok, MGK ; Stjernquist, Håkan LU ; Farthing-Nayak, PJ and Agardh, Elisabet LU (2003) In Diabetologia 46(4). p.511-513
Abstract
Aims/Hypothesis. This study aims to determine the prevalence of anti-pericyte autoantibodies in Type 2 diabetes and to characterize these autoantibodies as new markers of disease activity in diabetic retinopathy. Methods. A total of 299 patients with Type 2 diabetes participated in this study. Retinopathy was assessed by 7-field stereo fundus photography and was graded according to the ETDRS scale. Serum anti-pericyte autoantibodies were detected by immunofluorescence on tissue cultured bovine retinal pericytes. Results. The prevalence of anti-pericyte autoantibodies in Type 2 diabetic patients was 54% and was approximately equal in men and women. The prevalence was approximately 55% with retinopathy at grades from 10 to 53. At grades... (More)
Aims/Hypothesis. This study aims to determine the prevalence of anti-pericyte autoantibodies in Type 2 diabetes and to characterize these autoantibodies as new markers of disease activity in diabetic retinopathy. Methods. A total of 299 patients with Type 2 diabetes participated in this study. Retinopathy was assessed by 7-field stereo fundus photography and was graded according to the ETDRS scale. Serum anti-pericyte autoantibodies were detected by immunofluorescence on tissue cultured bovine retinal pericytes. Results. The prevalence of anti-pericyte autoantibodies in Type 2 diabetic patients was 54% and was approximately equal in men and women. The prevalence was approximately 55% with retinopathy at grades from 10 to 53. At grades above 53 the prevalence declined to 23% (p<0.0001). The highest prevalence by duration of diabetes, 70%, was found at 0 to 5 years and the lowest, 25% at more than 25 years duration (p<0.0001). Conclusion/interpretation. Anti-pericyte autoantibodies are present at high prevalence in Type 2 diabetes. Their presence during earlier stages of retinopathy could be due to a reaction with antigens expressed by "activated" pericytes. The decline in antibody prevalence in advanced retinopathy could mark pericyte loss and progression to an angiogenic retinal milieu. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
capillaries, retinal diseases, autommunity, diabetic retinopathy, pericytes, diabetes mellitus
in
Diabetologia
volume
46
issue
4
pages
511 - 513
publisher
Springer
external identifiers
  • wos:000183198600010
  • pmid:12739023
  • scopus:0038632185
ISSN
1432-0428
DOI
10.1007/s00125-003-1057-0
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Reconstructive Surgery (013240300), Ophthalmology (013242810), Unit on Vascular Diabetic Complications (013241510)
id
cef64cef-d1a0-4fef-b23e-d5962c820cc9 (old id 900368)
date added to LUP
2016-04-01 12:23:50
date last changed
2022-02-11 06:26:04
@article{cef64cef-d1a0-4fef-b23e-d5962c820cc9,
  abstract     = {{Aims/Hypothesis. This study aims to determine the prevalence of anti-pericyte autoantibodies in Type 2 diabetes and to characterize these autoantibodies as new markers of disease activity in diabetic retinopathy. Methods. A total of 299 patients with Type 2 diabetes participated in this study. Retinopathy was assessed by 7-field stereo fundus photography and was graded according to the ETDRS scale. Serum anti-pericyte autoantibodies were detected by immunofluorescence on tissue cultured bovine retinal pericytes. Results. The prevalence of anti-pericyte autoantibodies in Type 2 diabetic patients was 54% and was approximately equal in men and women. The prevalence was approximately 55% with retinopathy at grades from 10 to 53. At grades above 53 the prevalence declined to 23% (p&lt;0.0001). The highest prevalence by duration of diabetes, 70%, was found at 0 to 5 years and the lowest, 25% at more than 25 years duration (p&lt;0.0001). Conclusion/interpretation. Anti-pericyte autoantibodies are present at high prevalence in Type 2 diabetes. Their presence during earlier stages of retinopathy could be due to a reaction with antigens expressed by "activated" pericytes. The decline in antibody prevalence in advanced retinopathy could mark pericyte loss and progression to an angiogenic retinal milieu.}},
  author       = {{Nayak, RC and Agardh, Carl-David and Kwok, MGK and Stjernquist, Håkan and Farthing-Nayak, PJ and Agardh, Elisabet}},
  issn         = {{1432-0428}},
  keywords     = {{capillaries; retinal diseases; autommunity; diabetic retinopathy; pericytes; diabetes mellitus}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{511--513}},
  publisher    = {{Springer}},
  series       = {{Diabetologia}},
  title        = {{Circulating anti-pericyte autoantibodies are present in Type 2 diabetic patients and are associated with non-proliferative retinopathy}},
  url          = {{http://dx.doi.org/10.1007/s00125-003-1057-0}},
  doi          = {{10.1007/s00125-003-1057-0}},
  volume       = {{46}},
  year         = {{2003}},
}