Depletion of ATP and glucose in advanced human atherosclerotic plaques
(2017) In PLoS ONE 12(6). p.1-10- Abstract
Objective: Severe hypoxia develops close to the necrotic core of advanced human atherosclerotic plaques, but the energy metabolic consequences of this hypoxia are not known. In animal models, plaque hypoxia is also associated with depletion of glucose and ATP. ATP depletion may impair healing of plaques and promote necrotic core expansion. To investigate if ATP depletion is present in human plaques, we analyzed the distribution of energy metabolites (ATP, glucose, glycogen and lactate) in intermediate and advanced human plaques. Approach and results: Snap frozen carotid endarterectomies from 6 symptomatic patients were analyzed. Each endarterectomy included a large plaque ranging from the common carotid artery (CCA) to the internal... (More)
Objective: Severe hypoxia develops close to the necrotic core of advanced human atherosclerotic plaques, but the energy metabolic consequences of this hypoxia are not known. In animal models, plaque hypoxia is also associated with depletion of glucose and ATP. ATP depletion may impair healing of plaques and promote necrotic core expansion. To investigate if ATP depletion is present in human plaques, we analyzed the distribution of energy metabolites (ATP, glucose, glycogen and lactate) in intermediate and advanced human plaques. Approach and results: Snap frozen carotid endarterectomies from 6 symptomatic patients were analyzed. Each endarterectomy included a large plaque ranging from the common carotid artery (CCA) to the internal carotid artery (ICA). ATP, glucose, and glycogen concentrations were lower in advanced (ICA) compared to intermediate plaques (CCA), whereas lactate concentrations were higher. The lowest concentrations of ATP, glucose and glycogen were detected in the perinecrotic zone of advanced plaques. Conclusions: Our study demonstrates severe ATP depletion and glucose deficiency in the perinecrotic zone of human advanced atherosclerotic plaques. ATP depletion may impair healing of plaques and promote disease progression.
(Less)
- author
- organization
- publishing date
- 2017-06-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 12
- issue
- 6
- article number
- e0178877
- pages
- 1 - 10
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- scopus:85020007453
- pmid:28570702
- wos:000402611800131
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0178877
- language
- English
- LU publication?
- yes
- id
- 913aef8a-91d6-4044-8d09-3ed189583365
- date added to LUP
- 2017-06-19 10:55:37
- date last changed
- 2024-07-07 20:09:00
@article{913aef8a-91d6-4044-8d09-3ed189583365, abstract = {{<p>Objective: Severe hypoxia develops close to the necrotic core of advanced human atherosclerotic plaques, but the energy metabolic consequences of this hypoxia are not known. In animal models, plaque hypoxia is also associated with depletion of glucose and ATP. ATP depletion may impair healing of plaques and promote necrotic core expansion. To investigate if ATP depletion is present in human plaques, we analyzed the distribution of energy metabolites (ATP, glucose, glycogen and lactate) in intermediate and advanced human plaques. Approach and results: Snap frozen carotid endarterectomies from 6 symptomatic patients were analyzed. Each endarterectomy included a large plaque ranging from the common carotid artery (CCA) to the internal carotid artery (ICA). ATP, glucose, and glycogen concentrations were lower in advanced (ICA) compared to intermediate plaques (CCA), whereas lactate concentrations were higher. The lowest concentrations of ATP, glucose and glycogen were detected in the perinecrotic zone of advanced plaques. Conclusions: Our study demonstrates severe ATP depletion and glucose deficiency in the perinecrotic zone of human advanced atherosclerotic plaques. ATP depletion may impair healing of plaques and promote disease progression.</p>}}, author = {{Ekstrand, Matias and Widell, Emma and Hammar, Anna and Akyürek, Levent M. and Johansson, Martin and Fagerberg, Björn and Bergström, Göran and Levin, Malin C and Fogelstrand, Per and Borén, Jan and Levin, Max}}, issn = {{1932-6203}}, language = {{eng}}, month = {{06}}, number = {{6}}, pages = {{1--10}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Depletion of ATP and glucose in advanced human atherosclerotic plaques}}, url = {{http://dx.doi.org/10.1371/journal.pone.0178877}}, doi = {{10.1371/journal.pone.0178877}}, volume = {{12}}, year = {{2017}}, }