Dopamine regulates adult neurogenesis in the ventricular-subventricular zone via dopamine D3 angiotensin type 2 receptor interactions
Garcia-Garrote, Maria LU
; Parga, Juan A.
; Labandeira, Pablo J.
; Labandeira-Garcia, Jose Luis
and Rodriguez-Pallares, Jannette
(2021)
In Stem Cells
39(12).
p.1778-1794
- Abstract
Adult neurogenesis is a dynamic and highly regulated process, and different studies suggest that dopamine modulates ventricular-subventricular zone (V-SVZ) neurogenesis. However, the specific role of dopamine and the mechanisms/factors underlying its effects on physiological and pathological conditions such as Parkinson's disease (PD) are not fully understood. Recent studies have described counter-regulatory interactions between renin-angiotensin system (RAS) and dopamine in peripheral tissues and in the nigrostriatal system. We have previously demonstrated that angiotensin receptors regulate proliferation and generation of neuroblasts in the rodent V-SVZ. However, possible interactions between dopamine receptors and RAS in the V-SVZ... (More)
Adult neurogenesis is a dynamic and highly regulated process, and different studies suggest that dopamine modulates ventricular-subventricular zone (V-SVZ) neurogenesis. However, the specific role of dopamine and the mechanisms/factors underlying its effects on physiological and pathological conditions such as Parkinson's disease (PD) are not fully understood. Recent studies have described counter-regulatory interactions between renin-angiotensin system (RAS) and dopamine in peripheral tissues and in the nigrostriatal system. We have previously demonstrated that angiotensin receptors regulate proliferation and generation of neuroblasts in the rodent V-SVZ. However, possible interactions between dopamine receptors and RAS in the V-SVZ and their role in alterations of neurogenesis in animal models of PD have not been investigated. In V-SVZ cultures, activation of dopamine receptors induced changes in the expression of angiotensin receptors. Moreover, dopamine, via D2-like receptors and particularly D3 receptors, increased generation of neurospheres derived from the V-SVZ and this effect was mediated by angiotensin type-2 (AT2) receptors. In rats, we observed a marked reduction in proliferation and generation of neuroblasts in the V-SVZ of dopamine-depleted animals, and inhibition of AT1 receptors or activation of AT2 receptors restored proliferation and generation of neuroblasts to control levels. Moreover, intrastriatal mesencephalic grafts partially restored proliferation and generation of neuroblasts observed in the V-SVZ of dopamine-depleted rats. Our data revealed that dopamine and angiotensin receptor interactions play a major role in the regulation of V-SVZ and suggest potential beneficial effects of RAS modulators on the regulation of adult V-SVZ neurogenesis.
(Less)
- author
- Garcia-Garrote, Maria
LU
; Parga, Juan A.
; Labandeira, Pablo J.
; Labandeira-Garcia, Jose Luis
and Rodriguez-Pallares, Jannette
- publishing date
- 2021-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- angiotensin, dopamine receptors, dopaminergic grafts, neural stem cells, Parkinson's disease, subependymal zone
- in
- Stem Cells
- volume
- 39
- issue
- 12
- pages
- 1778 - 1794
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85115140439
- pmid:34521155
- ISSN
- 1066-5099
- DOI
- 10.1002/stem.3457
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2021 The Authors. STEM CELLS published by Wiley Periodicals LLC on behalf of AlphaMed Press.
- id
- 9192374f-3f20-4816-9c67-95b89042e02c
- date added to LUP
- 2025-01-24 11:52:47
- date last changed
- 2025-07-12 12:49:30
@article{9192374f-3f20-4816-9c67-95b89042e02c,
abstract = {{<p>Adult neurogenesis is a dynamic and highly regulated process, and different studies suggest that dopamine modulates ventricular-subventricular zone (V-SVZ) neurogenesis. However, the specific role of dopamine and the mechanisms/factors underlying its effects on physiological and pathological conditions such as Parkinson's disease (PD) are not fully understood. Recent studies have described counter-regulatory interactions between renin-angiotensin system (RAS) and dopamine in peripheral tissues and in the nigrostriatal system. We have previously demonstrated that angiotensin receptors regulate proliferation and generation of neuroblasts in the rodent V-SVZ. However, possible interactions between dopamine receptors and RAS in the V-SVZ and their role in alterations of neurogenesis in animal models of PD have not been investigated. In V-SVZ cultures, activation of dopamine receptors induced changes in the expression of angiotensin receptors. Moreover, dopamine, via D2-like receptors and particularly D3 receptors, increased generation of neurospheres derived from the V-SVZ and this effect was mediated by angiotensin type-2 (AT2) receptors. In rats, we observed a marked reduction in proliferation and generation of neuroblasts in the V-SVZ of dopamine-depleted animals, and inhibition of AT1 receptors or activation of AT2 receptors restored proliferation and generation of neuroblasts to control levels. Moreover, intrastriatal mesencephalic grafts partially restored proliferation and generation of neuroblasts observed in the V-SVZ of dopamine-depleted rats. Our data revealed that dopamine and angiotensin receptor interactions play a major role in the regulation of V-SVZ and suggest potential beneficial effects of RAS modulators on the regulation of adult V-SVZ neurogenesis.</p>}},
author = {{Garcia-Garrote, Maria and Parga, Juan A. and Labandeira, Pablo J. and Labandeira-Garcia, Jose Luis and Rodriguez-Pallares, Jannette}},
issn = {{1066-5099}},
keywords = {{angiotensin; dopamine receptors; dopaminergic grafts; neural stem cells; Parkinson's disease; subependymal zone}},
language = {{eng}},
number = {{12}},
pages = {{1778--1794}},
publisher = {{Oxford University Press}},
series = {{Stem Cells}},
title = {{Dopamine regulates adult neurogenesis in the ventricular-subventricular zone via dopamine D3 angiotensin type 2 receptor interactions}},
url = {{http://dx.doi.org/10.1002/stem.3457}},
doi = {{10.1002/stem.3457}},
volume = {{39}},
year = {{2021}},
}