Towards a standardized bioinformatics infrastructure for N- and O-glycomics
(2019) In Nature Communications 10(1).- Abstract
The mass spectrometry (MS)-based analysis of free polysaccharides and glycans released from proteins, lipids and proteoglycans increasingly relies on databases and software. Here, we review progress in the bioinformatics analysis of protein-released N- and O-linked glycans (N- and O-glycomics) and propose an e-infrastructure to overcome current deficits in data and experimental transparency. This workflow enables the standardized submission of MS-based glycomics information into the public repository UniCarb-DR. It implements the MIRAGE (Minimum Requirement for A Glycomics Experiment) reporting guidelines, storage of unprocessed MS data in the GlycoPOST repository and glycan structure registration using the GlyTouCan registry, thereby... (More)
The mass spectrometry (MS)-based analysis of free polysaccharides and glycans released from proteins, lipids and proteoglycans increasingly relies on databases and software. Here, we review progress in the bioinformatics analysis of protein-released N- and O-linked glycans (N- and O-glycomics) and propose an e-infrastructure to overcome current deficits in data and experimental transparency. This workflow enables the standardized submission of MS-based glycomics information into the public repository UniCarb-DR. It implements the MIRAGE (Minimum Requirement for A Glycomics Experiment) reporting guidelines, storage of unprocessed MS data in the GlycoPOST repository and glycan structure registration using the GlyTouCan registry, thereby supporting the development and extension of a glycan structure knowledgebase.
(Less)
- author
- organization
- publishing date
- 2019-07-22
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Communications
- volume
- 10
- issue
- 1
- article number
- 3275
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:31332201
- scopus:85070249334
- ISSN
- 2041-1723
- DOI
- 10.1038/s41467-019-11131-x
- language
- English
- LU publication?
- yes
- id
- 93e00fe5-1261-46bc-b7d5-bf1c29fc3a27
- date added to LUP
- 2019-08-27 16:38:14
- date last changed
- 2024-06-27 03:31:19
@article{93e00fe5-1261-46bc-b7d5-bf1c29fc3a27,
abstract = {{<p>The mass spectrometry (MS)-based analysis of free polysaccharides and glycans released from proteins, lipids and proteoglycans increasingly relies on databases and software. Here, we review progress in the bioinformatics analysis of protein-released N- and O-linked glycans (N- and O-glycomics) and propose an e-infrastructure to overcome current deficits in data and experimental transparency. This workflow enables the standardized submission of MS-based glycomics information into the public repository UniCarb-DR. It implements the MIRAGE (Minimum Requirement for A Glycomics Experiment) reporting guidelines, storage of unprocessed MS data in the GlycoPOST repository and glycan structure registration using the GlyTouCan registry, thereby supporting the development and extension of a glycan structure knowledgebase.</p>}},
author = {{Rojas-Macias, Miguel A and Mariethoz, Julien and Andersson, Peter and Jin, Chunsheng and Venkatakrishnan, Vignesh and Aoki, Nobuyuki P and Shinmachi, Daisuke and Ashwood, Christopher and Madunic, Katarina and Zhang, Tao and Miller, Rebecca L and Horlacher, Oliver and Struwe, Weston B and Watanabe, Yu and Okuda, Shujiro and Levander, Fredrik and Kolarich, Daniel and Rudd, Pauline M and Wuhrer, Manfred and Kettner, Carsten and Packer, Nicolle H and Aoki-Kinoshita, Kiyoko F and Lisacek, Frédérique and Karlsson, Niclas G}},
issn = {{2041-1723}},
language = {{eng}},
month = {{07}},
number = {{1}},
publisher = {{Nature Publishing Group}},
series = {{Nature Communications}},
title = {{Towards a standardized bioinformatics infrastructure for N- and O-glycomics}},
url = {{http://dx.doi.org/10.1038/s41467-019-11131-x}},
doi = {{10.1038/s41467-019-11131-x}},
volume = {{10}},
year = {{2019}},
}