Activation of the contact-phase system on bacterial surfaces - A clue to serious comlications in infections deseases
(1998) In Nature Medicine 4(3). p.298-302- Abstract
Fever, hypotension and bleeding disorders are common symptoms of sepsis and septic shock. The activation of the contact-phase system is thought to contribute to the development of these severe disease states by triggering proinflammatory and procoagulatory cascades; however, the underlying molecular mechanisms are obscure. Here we report that the components of the contact-phase system are assembled on the surface of Escherichia coil and Salmonella through their specific interactions with fibrous bacterial surface proteins, curli and fimbriae. As a consequence, the proinflammatory pathway is activated through the release of bradykinin, a potent inducer of fever, pain and hypotension. Absorption of contact-phase proteins and fibrinogen by... (More)
Fever, hypotension and bleeding disorders are common symptoms of sepsis and septic shock. The activation of the contact-phase system is thought to contribute to the development of these severe disease states by triggering proinflammatory and procoagulatory cascades; however, the underlying molecular mechanisms are obscure. Here we report that the components of the contact-phase system are assembled on the surface of Escherichia coil and Salmonella through their specific interactions with fibrous bacterial surface proteins, curli and fimbriae. As a consequence, the proinflammatory pathway is activated through the release of bradykinin, a potent inducer of fever, pain and hypotension. Absorption of contact-phase proteins and fibrinogen by bacterial surface proteins depletes relevant coagulation factors and causes a hypocoagulatory state. Thus, the complex interplay of microbe surface proteins and host contact-phase factors may contribute to the symptoms of sepsis and septic shock.
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- author
- Herwald, Heiko LU ; Mörgelin, Matthias LU ; Olsén, Arne LU ; Rhen, Mikael ; Dahlbäck, Björn LU ; Müller-Esterl, Werner and Björck, Lars LU
- organization
- publishing date
- 1998-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Medicine
- volume
- 4
- issue
- 3
- pages
- 298 - 302
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:2642635843
- pmid:9500602
- ISSN
- 1078-8956
- DOI
- 10.1038/nm0398-298
- language
- English
- LU publication?
- yes
- id
- 9419ec0c-939d-4380-a52b-cda2ef1d3ffe
- date added to LUP
- 2019-12-10 20:25:32
- date last changed
- 2024-09-19 14:47:58
@article{9419ec0c-939d-4380-a52b-cda2ef1d3ffe, abstract = {{<p>Fever, hypotension and bleeding disorders are common symptoms of sepsis and septic shock. The activation of the contact-phase system is thought to contribute to the development of these severe disease states by triggering proinflammatory and procoagulatory cascades; however, the underlying molecular mechanisms are obscure. Here we report that the components of the contact-phase system are assembled on the surface of Escherichia coil and Salmonella through their specific interactions with fibrous bacterial surface proteins, curli and fimbriae. As a consequence, the proinflammatory pathway is activated through the release of bradykinin, a potent inducer of fever, pain and hypotension. Absorption of contact-phase proteins and fibrinogen by bacterial surface proteins depletes relevant coagulation factors and causes a hypocoagulatory state. Thus, the complex interplay of microbe surface proteins and host contact-phase factors may contribute to the symptoms of sepsis and septic shock.</p>}}, author = {{Herwald, Heiko and Mörgelin, Matthias and Olsén, Arne and Rhen, Mikael and Dahlbäck, Björn and Müller-Esterl, Werner and Björck, Lars}}, issn = {{1078-8956}}, language = {{eng}}, month = {{03}}, number = {{3}}, pages = {{298--302}}, publisher = {{Nature Publishing Group}}, series = {{Nature Medicine}}, title = {{Activation of the contact-phase system on bacterial surfaces - A clue to serious comlications in infections deseases}}, url = {{http://dx.doi.org/10.1038/nm0398-298}}, doi = {{10.1038/nm0398-298}}, volume = {{4}}, year = {{1998}}, }