The dosimetric effect of residual breath-hold motion in pencil beam scanned proton therapy – An experimental study
(2019) In Radiotherapy and Oncology 134. p.135-142- Abstract
Background and purpose: Motion management in the treatment of lung cancer is necessary to assure highest quality of the delivered radiation therapy. In this study, the breath-hold technique is experimentally investigated for pencil beam scanned (PBS) proton therapy, with respect to the dosimetric effect of residual breath-hold motion. Material and methods: Three-dimensional (3D)-printed tumours extracted from CT scans of three patients were inserted into a dynamic anthropomorphic breathing phantom. The target was set up to move with the individual patient's tumour motion during breath-hold as previously assessed on fluoroscopy. Target dose was measured with radio-chromic film, and both single field uniform dose (SFUD) and... (More)
Background and purpose: Motion management in the treatment of lung cancer is necessary to assure highest quality of the delivered radiation therapy. In this study, the breath-hold technique is experimentally investigated for pencil beam scanned (PBS) proton therapy, with respect to the dosimetric effect of residual breath-hold motion. Material and methods: Three-dimensional (3D)-printed tumours extracted from CT scans of three patients were inserted into a dynamic anthropomorphic breathing phantom. The target was set up to move with the individual patient's tumour motion during breath-hold as previously assessed on fluoroscopy. Target dose was measured with radio-chromic film, and both single field uniform dose (SFUD) and intensity-modulated proton therapy (IMPT) plans were delivered. Experiments were repeated for each patient without any motion, to compute the relative dose deviation between static and breath-hold cases. Results: SFUD plans showed small dose deviations between static and breath-hold cases, as evidenced by the gamma pass rate (3%, 3 mm) of 85% or higher. Dose deviation was more evident for IMPT plans, with gamma pass rate reduced to 50–70%. Conclusions: The breath-hold technique is robust to residual intra-breath-hold motion for SFUD treatment plans, based on our experimental study. IMPT was less robust with larger detected dose deviations.
(Less)
- author
- publishing date
- 2019-02-14
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 4D phantom, Breath-hold, Lung tumours, PBS proton therapy
- in
- Radiotherapy and Oncology
- volume
- 134
- pages
- 135 - 142
- publisher
- Elsevier
- external identifiers
-
- pmid:31005207
- scopus:85061425719
- ISSN
- 0167-8140
- DOI
- 10.1016/j.radonc.2019.01.033
- language
- English
- LU publication?
- no
- additional info
- Funding Information: The authors would like to thank the Danish Society for Clinical Oncology ( DSKO ) for funding. The authors would further like to thank Viktor Eggspuehler for the 3D printing. Publisher Copyright: © 2019 Elsevier B.V.
- id
- 96d24523-c2a1-4d7b-baf9-b21a4d5221bb
- date added to LUP
- 2023-07-07 08:05:05
- date last changed
- 2024-06-15 04:24:49
@article{96d24523-c2a1-4d7b-baf9-b21a4d5221bb, abstract = {{<p>Background and purpose: Motion management in the treatment of lung cancer is necessary to assure highest quality of the delivered radiation therapy. In this study, the breath-hold technique is experimentally investigated for pencil beam scanned (PBS) proton therapy, with respect to the dosimetric effect of residual breath-hold motion. Material and methods: Three-dimensional (3D)-printed tumours extracted from CT scans of three patients were inserted into a dynamic anthropomorphic breathing phantom. The target was set up to move with the individual patient's tumour motion during breath-hold as previously assessed on fluoroscopy. Target dose was measured with radio-chromic film, and both single field uniform dose (SFUD) and intensity-modulated proton therapy (IMPT) plans were delivered. Experiments were repeated for each patient without any motion, to compute the relative dose deviation between static and breath-hold cases. Results: SFUD plans showed small dose deviations between static and breath-hold cases, as evidenced by the gamma pass rate (3%, 3 mm) of 85% or higher. Dose deviation was more evident for IMPT plans, with gamma pass rate reduced to 50–70%. Conclusions: The breath-hold technique is robust to residual intra-breath-hold motion for SFUD treatment plans, based on our experimental study. IMPT was less robust with larger detected dose deviations.</p>}}, author = {{Gorgisyan, Jenny and Lomax, Antony J. and Rosenschold, Per Munck af and Persson, Gitte F. and Krieger, Miriam and Colvill, Emma and Scherman, Jonas and Gagnon-Moisan, Francis and Egloff, Martina and Fattori, Giovanni and Engelholm, Svend Aage and Weber, Damien C. and Perrin, Rosalind}}, issn = {{0167-8140}}, keywords = {{4D phantom; Breath-hold; Lung tumours; PBS proton therapy}}, language = {{eng}}, month = {{02}}, pages = {{135--142}}, publisher = {{Elsevier}}, series = {{Radiotherapy and Oncology}}, title = {{The dosimetric effect of residual breath-hold motion in pencil beam scanned proton therapy – An experimental study}}, url = {{http://dx.doi.org/10.1016/j.radonc.2019.01.033}}, doi = {{10.1016/j.radonc.2019.01.033}}, volume = {{134}}, year = {{2019}}, }