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Predictive significance of high neutrophil ratio for thrombosis in myeloproliferative neoplasms : JSH-MPN-R18 subanalysis

Nagaharu, Keiki LU ; Ohya, Eiko ; Edahiro, Yoko ; Hashimoto, Yoshinori ; Ito, Tomoki ; Gotoh, Akihiko ; Nakamae, Mika ; Kimura, Fumihiko ; Koike, Michiaki and Kirito, Keita , et al. (2024) In Annals of Hematology 103(9). p.3535-3541
Abstract

Thrombosis in myeloproliferative neoplasms (MPNs) is an important clinical problem, and risk-stratified management is essential. To identify the clinical characteristics of thrombosis in patients with MPNs, a nationwide multi-institutional retrospective analysis (JSH-MPN-R18) was conducted. The aim of the present study was to perform a sub-analysis of JSH-MPN-R18 findings to clarify the predictive parameters for thrombosis among complete blood count (CBC) results. Among the patients enrolled in JSH-MPN-R18, those with essential thrombocythemia (ET; n = 1152) and polycythemia vera (PV; n = 456) were investigated. We analyzed and compared CBC parameters between patients with and those without any thrombotic events using Welch’s T-test.... (More)

Thrombosis in myeloproliferative neoplasms (MPNs) is an important clinical problem, and risk-stratified management is essential. To identify the clinical characteristics of thrombosis in patients with MPNs, a nationwide multi-institutional retrospective analysis (JSH-MPN-R18) was conducted. The aim of the present study was to perform a sub-analysis of JSH-MPN-R18 findings to clarify the predictive parameters for thrombosis among complete blood count (CBC) results. Among the patients enrolled in JSH-MPN-R18, those with essential thrombocythemia (ET; n = 1152) and polycythemia vera (PV; n = 456) were investigated. We analyzed and compared CBC parameters between patients with and those without any thrombotic events using Welch’s T-test. Statistical analyses were performed using the R statistical software. Thrombotic events were observed in 74 patients with ET. In multivariate analysis, only the neutrophil ratio was slightly but significantly higher for ET patients with thrombosis than for those without (p < 0.05). Of note, the absolute neutrophil count (aNeu) was considered a useful predictive tool for thrombosis among patients classified as low-risk according to the revised International Prognostic Score of Thrombosis for Essential Thrombocythemia. Among PV patients, those with thrombosis showed significantly higher hematocrit and aNeu than did those without thrombosis. As a thrombosis-associated factor, the neutrophil ratio was slightly but significantly elevated in patients with ET. This myeloid skew might reflect a higher value of JAK2 V617F allelic frequency in patients with ET with thrombosis; this was not clarified in JSH-MPN-R18. Further accumulation of evidence, including genetic information for JAK2 and other passenger mutations, is warranted.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Essential thrombosis, JAK2 mutation, Polycythemia vera, Thrombosis
in
Annals of Hematology
volume
103
issue
9
pages
7 pages
publisher
Springer
external identifiers
  • pmid:39037588
  • scopus:85199251716
ISSN
0939-5555
DOI
10.1007/s00277-024-05898-3
language
English
LU publication?
yes
id
96f9dcd2-8f2e-4e05-83e1-bb6ce872651f
date added to LUP
2024-12-02 11:02:20
date last changed
2025-07-01 04:24:10
@article{96f9dcd2-8f2e-4e05-83e1-bb6ce872651f,
  abstract     = {{<p>Thrombosis in myeloproliferative neoplasms (MPNs) is an important clinical problem, and risk-stratified management is essential. To identify the clinical characteristics of thrombosis in patients with MPNs, a nationwide multi-institutional retrospective analysis (JSH-MPN-R18) was conducted. The aim of the present study was to perform a sub-analysis of JSH-MPN-R18 findings to clarify the predictive parameters for thrombosis among complete blood count (CBC) results. Among the patients enrolled in JSH-MPN-R18, those with essential thrombocythemia (ET; n = 1152) and polycythemia vera (PV; n = 456) were investigated. We analyzed and compared CBC parameters between patients with and those without any thrombotic events using Welch’s T-test. Statistical analyses were performed using the R statistical software. Thrombotic events were observed in 74 patients with ET. In multivariate analysis, only the neutrophil ratio was slightly but significantly higher for ET patients with thrombosis than for those without (p &lt; 0.05). Of note, the absolute neutrophil count (aNeu) was considered a useful predictive tool for thrombosis among patients classified as low-risk according to the revised International Prognostic Score of Thrombosis for Essential Thrombocythemia. Among PV patients, those with thrombosis showed significantly higher hematocrit and aNeu than did those without thrombosis. As a thrombosis-associated factor, the neutrophil ratio was slightly but significantly elevated in patients with ET. This myeloid skew might reflect a higher value of JAK2 V617F allelic frequency in patients with ET with thrombosis; this was not clarified in JSH-MPN-R18. Further accumulation of evidence, including genetic information for JAK2 and other passenger mutations, is warranted.</p>}},
  author       = {{Nagaharu, Keiki and Ohya, Eiko and Edahiro, Yoko and Hashimoto, Yoshinori and Ito, Tomoki and Gotoh, Akihiko and Nakamae, Mika and Kimura, Fumihiko and Koike, Michiaki and Kirito, Keita and Wada, Hideho and Usuki, Kensuke and Tanaka, Takayuki and Mori, Takehiko and Wakita, Satoshi and Saito, Toshiki I. and Saito, Akiko M. and Shimoda, Kazuya and Kurokawa, Toshiro and Tomita, Akihiro and Kiyoi, Hitoshi and Akashi, Koichi and Matsumura, Itaru and Takenaka, Katsuto and Komatsu, Norio and Ohishi, Kohshi and Tawara, Isao and Sugimoto, Yuka}},
  issn         = {{0939-5555}},
  keywords     = {{Essential thrombosis; JAK2 mutation; Polycythemia vera; Thrombosis}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{3535--3541}},
  publisher    = {{Springer}},
  series       = {{Annals of Hematology}},
  title        = {{Predictive significance of high neutrophil ratio for thrombosis in myeloproliferative neoplasms : JSH-MPN-R18 subanalysis}},
  url          = {{http://dx.doi.org/10.1007/s00277-024-05898-3}},
  doi          = {{10.1007/s00277-024-05898-3}},
  volume       = {{103}},
  year         = {{2024}},
}