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Rheumatic and Musculoskeletal Diseases and Risk of Dementia : A Nested Case-Control Study

Kiadaliri, Ali LU orcid ; Dell'Isola, Andrea LU ; Turkiewicz, Aleksandra LU and Englund, Martin LU orcid (2024) In ACR Open Rheumatology p.1-7
Abstract

Objective: To investigate the associations between rheumatic and musculoskeletal diseases (RMDs) and incident dementia using population register-based data. Methods: This nested case-control study was conducted based on a cohort of residents in the Skåne region, Sweden, aged 50 years and older in 2009 without doctor-diagnosed dementia during 1998 to 2009 (n = 402,825). Individuals with a new main diagnosis of dementia during 2010 to 2019 were identified as incident patients with dementia (n = 22,131). Controls without diagnosed dementia were randomly matched 1:1 by sex, age, and Elixhauser comorbidity index using incidence density sampling. Separate conditional logistic regression analyses adjusted for confounders were fitted for the... (More)

Objective: To investigate the associations between rheumatic and musculoskeletal diseases (RMDs) and incident dementia using population register-based data. Methods: This nested case-control study was conducted based on a cohort of residents in the Skåne region, Sweden, aged 50 years and older in 2009 without doctor-diagnosed dementia during 1998 to 2009 (n = 402,825). Individuals with a new main diagnosis of dementia during 2010 to 2019 were identified as incident patients with dementia (n = 22,131). Controls without diagnosed dementia were randomly matched 1:1 by sex, age, and Elixhauser comorbidity index using incidence density sampling. Separate conditional logistic regression analyses adjusted for confounders were fitted for the following RMDs, diagnosed at least 2 years before dementia diagnosis as exposure: gout, osteoarthritis, rheumatoid arthritis, spondyloarthropathies (SpA), and systemic connective tissue disorders. Subgroup analyses by dementia subtype, sex, age, comorbidity, and RMDs/dementia identification were conducted. Results: Although gout (adjusted rate ratio 0.88; 95% confidence interval 0.79–0.97), osteoarthritis (0.92; 0.88–0.96), and systemic connective tissue disorders (0.91; 0.83–0.99) were associated with decreased risk of dementia, the associations for rheumatoid arthritis (1.05; 0.92–1.19) and SpA (1.17; 0.94–1.45) were inconclusive. The associations between RMDs and incident dementia were similar across sex, age, and comorbidity subgroups with a few exceptions (eg, an adjusted rate ratio of 0.99 [95% confidence interval 0.71–1.39] in males vs 1.31 [0.99–1.74] in female patients for SpA). Conclusion: Persons with diagnosed RMDs seem to have comparable or slightly lower risks of developing dementia compared with those without known RMD.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
ACR Open Rheumatology
pages
1 - 7
publisher
Wiley
external identifiers
  • scopus:85196656049
ISSN
2578-5745
DOI
10.1002/acr2.11705
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2024 The Author(s). ACR Open Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology.
id
9815903e-42b2-452c-83b6-dda2d552aa0f
date added to LUP
2024-07-08 11:33:19
date last changed
2024-07-09 09:38:41
@article{9815903e-42b2-452c-83b6-dda2d552aa0f,
  abstract     = {{<p>Objective: To investigate the associations between rheumatic and musculoskeletal diseases (RMDs) and incident dementia using population register-based data. Methods: This nested case-control study was conducted based on a cohort of residents in the Skåne region, Sweden, aged 50 years and older in 2009 without doctor-diagnosed dementia during 1998 to 2009 (n = 402,825). Individuals with a new main diagnosis of dementia during 2010 to 2019 were identified as incident patients with dementia (n = 22,131). Controls without diagnosed dementia were randomly matched 1:1 by sex, age, and Elixhauser comorbidity index using incidence density sampling. Separate conditional logistic regression analyses adjusted for confounders were fitted for the following RMDs, diagnosed at least 2 years before dementia diagnosis as exposure: gout, osteoarthritis, rheumatoid arthritis, spondyloarthropathies (SpA), and systemic connective tissue disorders. Subgroup analyses by dementia subtype, sex, age, comorbidity, and RMDs/dementia identification were conducted. Results: Although gout (adjusted rate ratio 0.88; 95% confidence interval 0.79–0.97), osteoarthritis (0.92; 0.88–0.96), and systemic connective tissue disorders (0.91; 0.83–0.99) were associated with decreased risk of dementia, the associations for rheumatoid arthritis (1.05; 0.92–1.19) and SpA (1.17; 0.94–1.45) were inconclusive. The associations between RMDs and incident dementia were similar across sex, age, and comorbidity subgroups with a few exceptions (eg, an adjusted rate ratio of 0.99 [95% confidence interval 0.71–1.39] in males vs 1.31 [0.99–1.74] in female patients for SpA). Conclusion: Persons with diagnosed RMDs seem to have comparable or slightly lower risks of developing dementia compared with those without known RMD.</p>}},
  author       = {{Kiadaliri, Ali and Dell'Isola, Andrea and Turkiewicz, Aleksandra and Englund, Martin}},
  issn         = {{2578-5745}},
  language     = {{eng}},
  pages        = {{1--7}},
  publisher    = {{Wiley}},
  series       = {{ACR Open Rheumatology}},
  title        = {{Rheumatic and Musculoskeletal Diseases and Risk of Dementia : A Nested Case-Control Study}},
  url          = {{http://dx.doi.org/10.1002/acr2.11705}},
  doi          = {{10.1002/acr2.11705}},
  year         = {{2024}},
}