Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Positron emission tomography ligand [11C]5-hydroxy-tryptophan can be used as a surrogate marker for the human endocrine pancreas

Eriksson, Olof ; Espes, Daniel ; Selvaraju, Ram K ; Jansson, Emma ; Antoni, Gunnar ; Sörensen, Jens ; Lubberink, Mark ; Biglarnia, Ali-Reza LU orcid ; Eriksson, Jan W and Sundin, Anders , et al. (2014) In Diabetes 63(10). p.37-3428
Abstract

In humans, a well-developed serotonin system is localized to the pancreatic islets while being absent in exocrine pancreas. Assessment of pancreatic serotonin biosynthesis could therefore be used to estimate the human endocrine pancreas. Proof of concept was tested in a prospective clinical trial by comparisons of type 1 diabetic (T1D) patients, with extensive reduction of β-cells, with healthy volunteers (HVs). C-peptide-negative (i.e., insulin-deficient) T1D subjects (n = 10) and HVs (n = 9) underwent dynamic positron emission tomography with the radiolabeled serotonin precursor [(11)C]5-hydroxy-tryptophan ([(11)C]5-HTP). A significant accumulation of [(11)C]5-HTP was obtained in the pancreas of the HVs, with large interindividual... (More)

In humans, a well-developed serotonin system is localized to the pancreatic islets while being absent in exocrine pancreas. Assessment of pancreatic serotonin biosynthesis could therefore be used to estimate the human endocrine pancreas. Proof of concept was tested in a prospective clinical trial by comparisons of type 1 diabetic (T1D) patients, with extensive reduction of β-cells, with healthy volunteers (HVs). C-peptide-negative (i.e., insulin-deficient) T1D subjects (n = 10) and HVs (n = 9) underwent dynamic positron emission tomography with the radiolabeled serotonin precursor [(11)C]5-hydroxy-tryptophan ([(11)C]5-HTP). A significant accumulation of [(11)C]5-HTP was obtained in the pancreas of the HVs, with large interindividual variation. A substantial and highly significant reduction (66%) in the pancreatic uptake of [(11)C]5-HTP in T1D subjects was observed, and this was most evident in the corpus and caudal regions of the pancreas where β-cells normally are the major constituent of the islets. [(11)C]5-HTP retention in the pancreas was reduced in T1D compared with nondiabetic subjects. Accumulation of [(11)C]5-HTP in the pancreas of both HVs and subjects with T1D was in agreement with previously reported morphological observations on the β-cell volume, implying that [(11)C]5-HTP retention is a useful noninvasive surrogate marker for the human endocrine pancreas.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
publishing date
type
Contribution to journal
publication status
published
keywords
5-Hydroxytryptophan/administration & dosage, Adolescent, Adult, Aged, Carbon Radioisotopes/administration & dosage, Diabetes Mellitus, Type 1/diagnostic imaging, Female, Humans, Islets of Langerhans/diagnostic imaging, Male, Middle Aged, Prospective Studies, Radionuclide Imaging, Retrospective Studies, Young Adult
in
Diabetes
volume
63
issue
10
pages
37 - 3428
publisher
American Diabetes Association Inc.
external identifiers
  • scopus:84907495074
  • pmid:24848067
ISSN
1939-327X
DOI
10.2337/db13-1877
language
English
LU publication?
no
additional info
© 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
id
9865b8c9-b693-427f-9fa3-037267ab0668
date added to LUP
2025-12-17 14:14:50
date last changed
2025-12-19 02:25:41
@article{9865b8c9-b693-427f-9fa3-037267ab0668,
  abstract     = {{<p>In humans, a well-developed serotonin system is localized to the pancreatic islets while being absent in exocrine pancreas. Assessment of pancreatic serotonin biosynthesis could therefore be used to estimate the human endocrine pancreas. Proof of concept was tested in a prospective clinical trial by comparisons of type 1 diabetic (T1D) patients, with extensive reduction of β-cells, with healthy volunteers (HVs). C-peptide-negative (i.e., insulin-deficient) T1D subjects (n = 10) and HVs (n = 9) underwent dynamic positron emission tomography with the radiolabeled serotonin precursor [(11)C]5-hydroxy-tryptophan ([(11)C]5-HTP). A significant accumulation of [(11)C]5-HTP was obtained in the pancreas of the HVs, with large interindividual variation. A substantial and highly significant reduction (66%) in the pancreatic uptake of [(11)C]5-HTP in T1D subjects was observed, and this was most evident in the corpus and caudal regions of the pancreas where β-cells normally are the major constituent of the islets. [(11)C]5-HTP retention in the pancreas was reduced in T1D compared with nondiabetic subjects. Accumulation of [(11)C]5-HTP in the pancreas of both HVs and subjects with T1D was in agreement with previously reported morphological observations on the β-cell volume, implying that [(11)C]5-HTP retention is a useful noninvasive surrogate marker for the human endocrine pancreas.</p>}},
  author       = {{Eriksson, Olof and Espes, Daniel and Selvaraju, Ram K and Jansson, Emma and Antoni, Gunnar and Sörensen, Jens and Lubberink, Mark and Biglarnia, Ali-Reza and Eriksson, Jan W and Sundin, Anders and Ahlström, Håkan and Eriksson, Barbro and Johansson, Lars and Carlsson, Per-Ola and Korsgren, Olle}},
  issn         = {{1939-327X}},
  keywords     = {{5-Hydroxytryptophan/administration & dosage; Adolescent; Adult; Aged; Carbon Radioisotopes/administration & dosage; Diabetes Mellitus, Type 1/diagnostic imaging; Female; Humans; Islets of Langerhans/diagnostic imaging; Male; Middle Aged; Prospective Studies; Radionuclide Imaging; Retrospective Studies; Young Adult}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{37--3428}},
  publisher    = {{American Diabetes Association Inc.}},
  series       = {{Diabetes}},
  title        = {{Positron emission tomography ligand [11C]5-hydroxy-tryptophan can be used as a surrogate marker for the human endocrine pancreas}},
  url          = {{http://dx.doi.org/10.2337/db13-1877}},
  doi          = {{10.2337/db13-1877}},
  volume       = {{63}},
  year         = {{2014}},
}