Sexual differentiation and development
(2006) p.266-272- Abstract
Normal sexual differentiation requires complex molecular events to take place in a precise order, and even though much knowledge has been gained in recent decades, further research is still needed to understand the pathogenesis of different disorders of sexual differentiation. For the clinician who is confronted with a child with sexual ambiguity, it is most important not to guess the sex but to initiate a proper diagnostic procedure, preferably done by a specialist team. Diagnosis generally requires a thorough clinical examination of the child and careful family history taking. The further diagnostic procedure includes cytogenetic hormonal and mutational analyses before sex assignment. Advances in molecular genetics are continuously... (More)
Normal sexual differentiation requires complex molecular events to take place in a precise order, and even though much knowledge has been gained in recent decades, further research is still needed to understand the pathogenesis of different disorders of sexual differentiation. For the clinician who is confronted with a child with sexual ambiguity, it is most important not to guess the sex but to initiate a proper diagnostic procedure, preferably done by a specialist team. Diagnosis generally requires a thorough clinical examination of the child and careful family history taking. The further diagnostic procedure includes cytogenetic hormonal and mutational analyses before sex assignment. Advances in molecular genetics are continuously providing tools for the detection of genetic defects and the primary diagnosis of intersex disorders. These methods may also be applied to prenatal diagnosis and carrier identification.
(Less)
- author
- Giwercman, Y. L. LU and Nordenskjöld, A.
- organization
- publishing date
- 2006-12-01
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- Andrology for the Clinician
- editor
- Schill, Wolf-Bernhard ; Comhaire, Frank H and Hargreave, Timothy B
- pages
- 266 - 272
- publisher
- Springer
- external identifiers
-
- scopus:84890217870
- ISBN
- 3540231714
- 9783540231714
- DOI
- 10.1007/3-540-33713-X_57
- language
- English
- LU publication?
- yes
- id
- 989e3b08-4169-4871-a965-eea633fb257f
- date added to LUP
- 2019-05-23 09:43:29
- date last changed
- 2022-01-31 20:48:41
@inbook{989e3b08-4169-4871-a965-eea633fb257f,
abstract = {{<p>Normal sexual differentiation requires complex molecular events to take place in a precise order, and even though much knowledge has been gained in recent decades, further research is still needed to understand the pathogenesis of different disorders of sexual differentiation. For the clinician who is confronted with a child with sexual ambiguity, it is most important not to guess the sex but to initiate a proper diagnostic procedure, preferably done by a specialist team. Diagnosis generally requires a thorough clinical examination of the child and careful family history taking. The further diagnostic procedure includes cytogenetic hormonal and mutational analyses before sex assignment. Advances in molecular genetics are continuously providing tools for the detection of genetic defects and the primary diagnosis of intersex disorders. These methods may also be applied to prenatal diagnosis and carrier identification.</p>}},
author = {{Giwercman, Y. L. and Nordenskjöld, A.}},
booktitle = {{Andrology for the Clinician}},
editor = {{Schill, Wolf-Bernhard and Comhaire, Frank H and Hargreave, Timothy B}},
isbn = {{3540231714}},
language = {{eng}},
month = {{12}},
pages = {{266--272}},
publisher = {{Springer}},
title = {{Sexual differentiation and development}},
url = {{http://dx.doi.org/10.1007/3-540-33713-X_57}},
doi = {{10.1007/3-540-33713-X_57}},
year = {{2006}},
}