Islet cell related antibodies and type 1 diabetes associated with echovirus 30 epidemic : a case report
(2005) In Journal of Medical Virology 76(3). p.7-373- Abstract
Type 1 diabetes associated genes account for less than 50% of disease susceptibility. Human enteroviruses have been implicated as environmental factors that might trigger and/or accelerate this autoimmune disorder. We now report of a 12-year-old girl that developed pancreatic autoimmunity and type 1 diabetes after enteroviral infection. Diabetes-associated autoimmunity was evaluated by measurement of several islet cell related autoantibodies. Neutralizing antibodies to different enteroviruses were determined in the case and eight children suffering from aseptic meningitis during a large scale epidemic. Several types of diabetes-associated antibodies were detected post-infection in the adolescent with newly diagnosed type 1 diabetes,... (More)
Type 1 diabetes associated genes account for less than 50% of disease susceptibility. Human enteroviruses have been implicated as environmental factors that might trigger and/or accelerate this autoimmune disorder. We now report of a 12-year-old girl that developed pancreatic autoimmunity and type 1 diabetes after enteroviral infection. Diabetes-associated autoimmunity was evaluated by measurement of several islet cell related autoantibodies. Neutralizing antibodies to different enteroviruses were determined in the case and eight children suffering from aseptic meningitis during a large scale epidemic. Several types of diabetes-associated antibodies were detected post-infection in the adolescent with newly diagnosed type 1 diabetes, including islet cell antibodies (ICA) and tyrosine phosphatase antibodies (IA2A). ICA but not IA2A appeared in the non-diabetic enterovirus-infected subjects. Based on virological studies, type 1 diabetes pathogenesis process could have been triggered by echovirus 30 infections. This study provides the first evidence of an association between echovirus 30 infection with the presence of pancreatic autoimmunity and type 1 diabetes. Our data suggest that echovirus 30 Cuban strain could be considered a potentially diabetogenic enteroviral variant.
(Less)
- author
- publishing date
- 2005-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adolescent, Arthritis, Infectious/blood, Autoantibodies/blood, Child, Child, Preschool, Cuba, Diabetes Mellitus, Type 1/etiology, Enterovirus Infections/complications, Female, Humans, Infant, Islets of Langerhans/immunology, Male, Neutralization Tests
- in
- Journal of Medical Virology
- volume
- 76
- issue
- 3
- pages
- 5 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:20044363615
- pmid:15902705
- ISSN
- 0146-6615
- DOI
- 10.1002/jmv.20368
- language
- English
- LU publication?
- no
- additional info
- Copyright (c) 2005 Wiley-Liss, Inc.
- id
- 98e6040b-1697-4271-8bf2-755fc78994fb
- date added to LUP
- 2019-07-08 14:51:45
- date last changed
- 2024-10-02 09:12:52
@article{98e6040b-1697-4271-8bf2-755fc78994fb, abstract = {{<p>Type 1 diabetes associated genes account for less than 50% of disease susceptibility. Human enteroviruses have been implicated as environmental factors that might trigger and/or accelerate this autoimmune disorder. We now report of a 12-year-old girl that developed pancreatic autoimmunity and type 1 diabetes after enteroviral infection. Diabetes-associated autoimmunity was evaluated by measurement of several islet cell related autoantibodies. Neutralizing antibodies to different enteroviruses were determined in the case and eight children suffering from aseptic meningitis during a large scale epidemic. Several types of diabetes-associated antibodies were detected post-infection in the adolescent with newly diagnosed type 1 diabetes, including islet cell antibodies (ICA) and tyrosine phosphatase antibodies (IA2A). ICA but not IA2A appeared in the non-diabetic enterovirus-infected subjects. Based on virological studies, type 1 diabetes pathogenesis process could have been triggered by echovirus 30 infections. This study provides the first evidence of an association between echovirus 30 infection with the presence of pancreatic autoimmunity and type 1 diabetes. Our data suggest that echovirus 30 Cuban strain could be considered a potentially diabetogenic enteroviral variant.</p>}}, author = {{Cabrera-Rode, Eduardo and Sarmiento, Luis and Molina, Gisela and Pérez, Cecilia and Arranz, Celeste and Galvan, José A and Prieto, Mirta and Barrios, Julio and Palomera, Rosa and Fonseca, Magile and Mas, Pedro and Díaz-Horta, Oscar and Diaz-Diaz, Oscar}}, issn = {{0146-6615}}, keywords = {{Adolescent; Arthritis, Infectious/blood; Autoantibodies/blood; Child; Child, Preschool; Cuba; Diabetes Mellitus, Type 1/etiology; Enterovirus Infections/complications; Female; Humans; Infant; Islets of Langerhans/immunology; Male; Neutralization Tests}}, language = {{eng}}, number = {{3}}, pages = {{7--373}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Journal of Medical Virology}}, title = {{Islet cell related antibodies and type 1 diabetes associated with echovirus 30 epidemic : a case report}}, url = {{http://dx.doi.org/10.1002/jmv.20368}}, doi = {{10.1002/jmv.20368}}, volume = {{76}}, year = {{2005}}, }