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Research priorities to address the global burden of chronic obstructive pulmonary disease (COPD) in the next decade

Adeloye, Davies ; Agarwal, Dhiraj ; Barnes, Peter J. ; Bonay, Marcel ; van Boven, Job F. ; Bryant, Jamie ; Caramori, Gaetano ; Dockrell, David ; D'Urzo, Anthony and Ekström, Magnus LU orcid , et al. (2021) In Journal of Global Health 11. p.15003-15003
Abstract

Background: The global prevalence of chronic obstructive pulmonary disease (COPD) has increased markedly in recent decades. Given the scarcity of resources available to address global health challenges and respiratory medicine being relatively under-invested in, it is important to define research priorities for COPD globally. In this paper, we aim to identify a ranked set of COPD research priorities that need to be addressed in the next 10 years to substantially reduce the global impact of COPD. Methods: We adapted the Child Health and Nutrition Research Initiative (CHNRI) methodology to identify global COPD research priorities. Results: 62 experts contributed 230 research ideas, which were scored by 34 researchers according to six... (More)

Background: The global prevalence of chronic obstructive pulmonary disease (COPD) has increased markedly in recent decades. Given the scarcity of resources available to address global health challenges and respiratory medicine being relatively under-invested in, it is important to define research priorities for COPD globally. In this paper, we aim to identify a ranked set of COPD research priorities that need to be addressed in the next 10 years to substantially reduce the global impact of COPD. Methods: We adapted the Child Health and Nutrition Research Initiative (CHNRI) methodology to identify global COPD research priorities. Results: 62 experts contributed 230 research ideas, which were scored by 34 researchers according to six pre-defined criteria: answerability, effectiveness, feasibility, deliverability, burden reduction, and equity. The top-ranked research priority was the need for new effective strategies to support smoking cessation. Of the top 20 overall research priorities, six were focused on feasible and cost-effective pulmonary rehabilitation delivery and access, particularly in primary/community care and low-resource settings. Three of the top 10 overall priorities called for research on improved screening and accurate diagnostic methods for COPD in low-resource primary care settings. Further ideas that drew support involved a better understanding of risk factors for COPD, development of effective training programmes for health workers and physicians in low resource settings, and evaluation of novel interventions to encourage physical activity. Conclusions: The experts agreed that the most pressing feasible research questions to address in the next decade for COPD reduction were on prevention, diagnosis and rehabilitation of COPD, especially in low resource settings. The largest gains should be expected in low- and middle-income countries (LMIC) settings, as the large majority of COPD deaths occur in those settings. Research priorities identified by this systematic international process should inform and motivate policymakers, funders, and researchers to support and conduct research to reduce the global burden of COPD.

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Contribution to journal
publication status
published
subject
in
Journal of Global Health
volume
11
pages
1 pages
publisher
Edinburgh University Global Health Society
external identifiers
  • pmid:34737870
  • scopus:85121626709
ISSN
2047-2986
DOI
10.7189/jogh.11.15003
language
English
LU publication?
yes
additional info
Publisher Copyright: Copyright © 2021 by the Journal of Global Health. All rights reserved.
id
9b6705bc-bc6f-423e-9e45-b4d8c2a35770
date added to LUP
2022-02-24 12:37:45
date last changed
2024-05-18 17:33:04
@article{9b6705bc-bc6f-423e-9e45-b4d8c2a35770,
  abstract     = {{<p>Background: The global prevalence of chronic obstructive pulmonary disease (COPD) has increased markedly in recent decades. Given the scarcity of resources available to address global health challenges and respiratory medicine being relatively under-invested in, it is important to define research priorities for COPD globally. In this paper, we aim to identify a ranked set of COPD research priorities that need to be addressed in the next 10 years to substantially reduce the global impact of COPD. Methods: We adapted the Child Health and Nutrition Research Initiative (CHNRI) methodology to identify global COPD research priorities. Results: 62 experts contributed 230 research ideas, which were scored by 34 researchers according to six pre-defined criteria: answerability, effectiveness, feasibility, deliverability, burden reduction, and equity. The top-ranked research priority was the need for new effective strategies to support smoking cessation. Of the top 20 overall research priorities, six were focused on feasible and cost-effective pulmonary rehabilitation delivery and access, particularly in primary/community care and low-resource settings. Three of the top 10 overall priorities called for research on improved screening and accurate diagnostic methods for COPD in low-resource primary care settings. Further ideas that drew support involved a better understanding of risk factors for COPD, development of effective training programmes for health workers and physicians in low resource settings, and evaluation of novel interventions to encourage physical activity. Conclusions: The experts agreed that the most pressing feasible research questions to address in the next decade for COPD reduction were on prevention, diagnosis and rehabilitation of COPD, especially in low resource settings. The largest gains should be expected in low- and middle-income countries (LMIC) settings, as the large majority of COPD deaths occur in those settings. Research priorities identified by this systematic international process should inform and motivate policymakers, funders, and researchers to support and conduct research to reduce the global burden of COPD.</p>}},
  author       = {{Adeloye, Davies and Agarwal, Dhiraj and Barnes, Peter J. and Bonay, Marcel and van Boven, Job F. and Bryant, Jamie and Caramori, Gaetano and Dockrell, David and D'Urzo, Anthony and Ekström, Magnus and Erhabor, Gregory and Esteban, Cristóbal and Greene, Catherine M. and Hurst, John and Juvekar, Sanjay and Khoo, Ee Ming and Ko, Fanny W. and Lipworth, Brian and López-Campos, Jose L. and Maddocks, Matthew and Mannino, David M. and Martinez, Fernando J. and Martinez-Garcia, Miguel A. and McNamara, Renae J. and Miravitlles, Marc and Pinnock, Hilary and Pooler, Alison and Quint, Jennifer K. and Schwarz, Peter and Slavich, George M. and Song, Peige and Tai, Andrew and Watz, Henrik and Wedzicha, Jadwiga A. and Williams, Michelle C. and Campbell, Harry and Sheikh, Aziz and Rudan, Igor}},
  issn         = {{2047-2986}},
  language     = {{eng}},
  pages        = {{15003--15003}},
  publisher    = {{Edinburgh University Global Health Society}},
  series       = {{Journal of Global Health}},
  title        = {{Research priorities to address the global burden of chronic obstructive pulmonary disease (COPD) in the next decade}},
  url          = {{http://dx.doi.org/10.7189/jogh.11.15003}},
  doi          = {{10.7189/jogh.11.15003}},
  volume       = {{11}},
  year         = {{2021}},
}