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Method for preparing taxane derivatives

Pyo, Sang-Hyun LU orcid ; Cho, Jin-Suk ; Kim, Moon‐Suk ; Song, Jai-Young and Choi, Ho-Joon (2012) US8633326B2
Abstract
Provided is a method for preparing a taxane derivative, comprising: carrying out condensation of a phenylisoserine derivatives having a protective group introduced thereto or a mixture of isomers thereof, as a side chain, with a baccatin III derivative or 10-deacetyl-baccatin III derivative to obtain a mixture of isomers; separating the isomers via chromatography; and carrying out a reversion of the stereochemical structure of a selectively separated isomer, which is suitable for producing a taxane derivative in a large scale with high yield.
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inventor
LU orcid ; Cho, Jin-Suk ; Kim, Moon‐Suk ; Song, Jai-Young and Choi, Ho-Joon
publishing date
type
Patent
publication status
published
subject
publisher
United States Patent and Trademark Office
patent number
US8633326B2
language
English
LU publication?
no
id
9bb81be9-738b-4118-b24d-7c318756d386
date added to LUP
2025-09-16 16:33:47
date last changed
2025-09-22 16:48:55
@misc{9bb81be9-738b-4118-b24d-7c318756d386,
  abstract     = {{Provided is a method for preparing a taxane derivative, comprising: carrying out condensation of a phenylisoserine derivatives having a protective group introduced thereto or a mixture of isomers thereof, as a side chain, with a baccatin III derivative or 10-deacetyl-baccatin III derivative to obtain a mixture of isomers; separating the isomers via chromatography; and carrying out a reversion of the stereochemical structure of a selectively separated isomer, which is suitable for producing a taxane derivative in a large scale with high yield.}},
  author       = {{Pyo, Sang-Hyun and Cho, Jin-Suk and Kim, Moon‐Suk and Song, Jai-Young and Choi, Ho-Joon}},
  language     = {{eng}},
  month        = {{02}},
  note         = {{Patent, Patent Number: US8633326B2}},
  publisher    = {{United States Patent and Trademark Office}},
  title        = {{Method for preparing taxane derivatives}},
  year         = {{2012}},
}