Contact allergy to oxidized geraniol among Swedish dermatitis patients—A multicentre study by the Swedish Contact Dermatitis Research Group
(2018) In Contact Dermatitis 79(4). p.232-238- Abstract
Background: Geraniol is a widely used fragrance terpene, and is included in fragrance mix I. Geraniol is prone to autoxidation, forming the skin sensitizers geranial, neral, and geraniol-7-hydroperoxide. Oxidized geraniol has previously been patch tested in 1 clinic, giving 1% to 4.6% positive reactions in consecutive patients when tested at 2% to 11%. Aim: To compare test reactions to pure and oxidized geraniol, to compare 2 different test concentrations of oxidized geraniol and to investigate the pattern of concomitant reactions to fragrance markers of the baseline series in a multicentre setting. Methods: One thousand four hundred and seventy-six consecutive patients referred for patch testing were patch tested with geraniol 6% pet.... (More)
Background: Geraniol is a widely used fragrance terpene, and is included in fragrance mix I. Geraniol is prone to autoxidation, forming the skin sensitizers geranial, neral, and geraniol-7-hydroperoxide. Oxidized geraniol has previously been patch tested in 1 clinic, giving 1% to 4.6% positive reactions in consecutive patients when tested at 2% to 11%. Aim: To compare test reactions to pure and oxidized geraniol, to compare 2 different test concentrations of oxidized geraniol and to investigate the pattern of concomitant reactions to fragrance markers of the baseline series in a multicentre setting. Methods: One thousand four hundred and seventy-six consecutive patients referred for patch testing were patch tested with geraniol 6% pet. and oxidized geraniol 6% and 11% pet. Results: Pure geraniol 6% pet., oxidized geraniol 6% pet. and oxidized geraniol 11% pet. gave 1%, 3% and 8% positive patch test reactions and 0.7%, 3% and 5% doubtful reactions, respectively. Approximately 50% of the patients with doubtful reactions to oxidized geraniol 6% pet. had positive reactions to oxidized geraniol 11% pet. Conclusions: Oxidized geraniol 11% pet. provides better detection than oxidized geraniol 6% pet. As most patients reacted only to oxidized geraniol, it is important to explore further whether oxidized geraniol should be included in a baseline patch test series.
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- author
- Hagvall, Lina ; Bruze, Magnus LU ; Engfeldt, Malin LU ; Isaksson, Marléne LU ; Lindberg, Magnus ; Ryberg, Kristina LU ; Stenberg, Berndt ; Svedman, Cecilia LU ; Karlberg, Ann Therese and Bråred Christensson, Johanna
- organization
- publishing date
- 2018-06-21
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- allergic contact dermatitis, autoxidation, fragrance contact allergy, fragrance mix I, geraniol, patch testing, terpenes
- in
- Contact Dermatitis
- volume
- 79
- issue
- 4
- pages
- 7 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85052815523
- pmid:29926925
- ISSN
- 0105-1873
- DOI
- 10.1111/cod.13047
- language
- English
- LU publication?
- yes
- id
- 9cddf06c-db4f-499f-9d54-74d36e5c4364
- date added to LUP
- 2018-09-25 10:52:54
- date last changed
- 2024-04-15 11:57:27
@article{9cddf06c-db4f-499f-9d54-74d36e5c4364,
abstract = {{<p>Background: Geraniol is a widely used fragrance terpene, and is included in fragrance mix I. Geraniol is prone to autoxidation, forming the skin sensitizers geranial, neral, and geraniol-7-hydroperoxide. Oxidized geraniol has previously been patch tested in 1 clinic, giving 1% to 4.6% positive reactions in consecutive patients when tested at 2% to 11%. Aim: To compare test reactions to pure and oxidized geraniol, to compare 2 different test concentrations of oxidized geraniol and to investigate the pattern of concomitant reactions to fragrance markers of the baseline series in a multicentre setting. Methods: One thousand four hundred and seventy-six consecutive patients referred for patch testing were patch tested with geraniol 6% pet. and oxidized geraniol 6% and 11% pet. Results: Pure geraniol 6% pet., oxidized geraniol 6% pet. and oxidized geraniol 11% pet. gave 1%, 3% and 8% positive patch test reactions and 0.7%, 3% and 5% doubtful reactions, respectively. Approximately 50% of the patients with doubtful reactions to oxidized geraniol 6% pet. had positive reactions to oxidized geraniol 11% pet. Conclusions: Oxidized geraniol 11% pet. provides better detection than oxidized geraniol 6% pet. As most patients reacted only to oxidized geraniol, it is important to explore further whether oxidized geraniol should be included in a baseline patch test series.</p>}},
author = {{Hagvall, Lina and Bruze, Magnus and Engfeldt, Malin and Isaksson, Marléne and Lindberg, Magnus and Ryberg, Kristina and Stenberg, Berndt and Svedman, Cecilia and Karlberg, Ann Therese and Bråred Christensson, Johanna}},
issn = {{0105-1873}},
keywords = {{allergic contact dermatitis; autoxidation; fragrance contact allergy; fragrance mix I; geraniol; patch testing; terpenes}},
language = {{eng}},
month = {{06}},
number = {{4}},
pages = {{232--238}},
publisher = {{Wiley-Blackwell}},
series = {{Contact Dermatitis}},
title = {{Contact allergy to oxidized geraniol among Swedish dermatitis patients—A multicentre study by the Swedish Contact Dermatitis Research Group}},
url = {{http://dx.doi.org/10.1111/cod.13047}},
doi = {{10.1111/cod.13047}},
volume = {{79}},
year = {{2018}},
}