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The genetic evolution of melanoma

Harbst, Katja LU orcid and Jönsson, Göran LU (2018) p.105-114
Abstract
Melanoma tumors are driven by a hyperactivated mitogen-activated protein kinase (MAPK) signalling pathway, and therefore can generally be classified by mutations within the B-Raf proto-oncogene (BRAF), RAS family of proto-oncogenes, neurofibromin 1 (NF1), or other genes. At the transcriptional level, several genetic classifications of melanoma have converged on the distinction between melanogenesis (previously microphthalmia) associated transcription factor (MITF)-low and MITF-high phenotypes and expression of immune-related genes. Mutation-based melanoma subtypes are not prognostic, nor are they associated to transcriptomic subtypes, which are in turn prognostic. Intratumoral heterogeneity of melanoma cells adds another layer of... (More)
Melanoma tumors are driven by a hyperactivated mitogen-activated protein kinase (MAPK) signalling pathway, and therefore can generally be classified by mutations within the B-Raf proto-oncogene (BRAF), RAS family of proto-oncogenes, neurofibromin 1 (NF1), or other genes. At the transcriptional level, several genetic classifications of melanoma have converged on the distinction between melanogenesis (previously microphthalmia) associated transcription factor (MITF)-low and MITF-high phenotypes and expression of immune-related genes. Mutation-based melanoma subtypes are not prognostic, nor are they associated to transcriptomic subtypes, which are in turn prognostic. Intratumoral heterogeneity of melanoma cells adds another layer of complexity, with recent findings of mutational and transcriptional heterogeneity within melanoma tumors. Furthermore, multiple genetic changes have been associated with different stages of melanoma progression. Mutational signatures may also be differentiated at early and late stages of melanoma progression. (Less)
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Melanoma, Genomic, Heterogeneity, Subtype classification, Progression, Evolution
host publication
Melanoma : A Modern Multidisciplinary Approach - A Modern Multidisciplinary Approach
editor
Riker, Adam I.
pages
10 pages
publisher
Springer
external identifiers
  • scopus:85076009791
ISBN
9783319783093
9783319783109
DOI
10.1007/978-3-319-78310-9_6
language
English
LU publication?
yes
id
9d89f59d-7e20-41b4-b656-386c120083b3
date added to LUP
2020-01-02 10:33:53
date last changed
2024-03-04 11:22:45
@inbook{9d89f59d-7e20-41b4-b656-386c120083b3,
  abstract     = {{Melanoma tumors are driven by a hyperactivated mitogen-activated protein kinase (MAPK) signalling pathway, and therefore can generally be classified by mutations within the B-Raf proto-oncogene (BRAF), RAS family of proto-oncogenes, neurofibromin 1 (NF1), or other genes. At the transcriptional level, several genetic classifications of melanoma have converged on the distinction between melanogenesis (previously microphthalmia) associated transcription factor (MITF)-low and MITF-high phenotypes and expression of immune-related genes. Mutation-based melanoma subtypes are not prognostic, nor are they associated to transcriptomic subtypes, which are in turn prognostic. Intratumoral heterogeneity of melanoma cells adds another layer of complexity, with recent findings of mutational and transcriptional heterogeneity within melanoma tumors. Furthermore, multiple genetic changes have been associated with different stages of melanoma progression. Mutational signatures may also be differentiated at early and late stages of melanoma progression.}},
  author       = {{Harbst, Katja and Jönsson, Göran}},
  booktitle    = {{Melanoma : A Modern Multidisciplinary Approach}},
  editor       = {{Riker, Adam I.}},
  isbn         = {{9783319783093}},
  keywords     = {{Melanoma; Genomic; Heterogeneity; Subtype classification; Progression; Evolution}},
  language     = {{eng}},
  month        = {{06}},
  pages        = {{105--114}},
  publisher    = {{Springer}},
  title        = {{The genetic evolution of melanoma}},
  url          = {{http://dx.doi.org/10.1007/978-3-319-78310-9_6}},
  doi          = {{10.1007/978-3-319-78310-9_6}},
  year         = {{2018}},
}