Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Poikilosis - Pervasive biological variation

Vihinen, Mauno LU orcid (2020) In F1000Research 9.
Abstract

Biological systems are dynamic and display heterogeneity at all levels. Ubiquitous heterogeneity, here called for poikilosis, is an integral and important property of organisms and in molecules, systems and processes within them. Traditionally, heterogeneity in biology and experiments has been considered as unwanted noise, here poikilosis is shown to be the normal state. Acceptable variation ranges are called as lagom. Non-lagom, variations that are too extensive, have negative effects, which influence interconnected levels and once the variation is large enough cause a disease and can lead even to death. Poikilosis has numerous applications and consequences e.g. for how to design, analyze and report experiments, how to develop and... (More)

Biological systems are dynamic and display heterogeneity at all levels. Ubiquitous heterogeneity, here called for poikilosis, is an integral and important property of organisms and in molecules, systems and processes within them. Traditionally, heterogeneity in biology and experiments has been considered as unwanted noise, here poikilosis is shown to be the normal state. Acceptable variation ranges are called as lagom. Non-lagom, variations that are too extensive, have negative effects, which influence interconnected levels and once the variation is large enough cause a disease and can lead even to death. Poikilosis has numerous applications and consequences e.g. for how to design, analyze and report experiments, how to develop and apply prediction and modelling methods, and in diagnosis and treatment of diseases. Poikilosis-aware new and practical definitions are provided for life, death, senescence, disease, and lagom. Poikilosis is the first new unifying theory in biology since evolution and should be considered in every scientific study.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biological heterogeneity, Effective variation, Lagom, Noise, Poikilosis, Unifying theory
in
F1000Research
volume
9
article number
602
publisher
F1000 Research Ltd.
external identifiers
  • scopus:85090819725
  • pmid:32913639
ISSN
2046-1402
DOI
10.12688/f1000research.24173.1
language
English
LU publication?
yes
id
9edda1d1-101e-4d0a-b947-c03c58b4efd5
date added to LUP
2020-10-26 10:10:11
date last changed
2024-06-12 22:43:26
@article{9edda1d1-101e-4d0a-b947-c03c58b4efd5,
  abstract     = {{<p>Biological systems are dynamic and display heterogeneity at all levels. Ubiquitous heterogeneity, here called for poikilosis, is an integral and important property of organisms and in molecules, systems and processes within them. Traditionally, heterogeneity in biology and experiments has been considered as unwanted noise, here poikilosis is shown to be the normal state. Acceptable variation ranges are called as lagom. Non-lagom, variations that are too extensive, have negative effects, which influence interconnected levels and once the variation is large enough cause a disease and can lead even to death. Poikilosis has numerous applications and consequences e.g. for how to design, analyze and report experiments, how to develop and apply prediction and modelling methods, and in diagnosis and treatment of diseases. Poikilosis-aware new and practical definitions are provided for life, death, senescence, disease, and lagom. Poikilosis is the first new unifying theory in biology since evolution and should be considered in every scientific study.</p>}},
  author       = {{Vihinen, Mauno}},
  issn         = {{2046-1402}},
  keywords     = {{Biological heterogeneity; Effective variation; Lagom; Noise; Poikilosis; Unifying theory}},
  language     = {{eng}},
  publisher    = {{F1000 Research Ltd.}},
  series       = {{F1000Research}},
  title        = {{Poikilosis - Pervasive biological variation}},
  url          = {{http://dx.doi.org/10.12688/f1000research.24173.1}},
  doi          = {{10.12688/f1000research.24173.1}},
  volume       = {{9}},
  year         = {{2020}},
}