Insulin Pump Therapy and Adverse Skin Reactions With Focus on Allergic Contact Dermatitis in Individuals Living With Diabetes Mellitus : A Systematic Review and Clinical-Based Update
(2024) In Journal of diabetes science and technology- Abstract
Background: The use of insulin pumps (continuous subcutaneous insulin infusion [CSII]) in individuals living with type 1 diabetes (T1D) improves disease control. However, adverse skin reactions may hamper compliance. We aimed to assess the relationship of insulin pumps, particularly that of infusion set therapy, used in children and adults with T1D and dermatitis including allergic contact dermatitis (ACD). Methods: A systematic search of PubMed, and EMBASE, of full-text studies reporting dermatitis in persons with diabetes using a CSII was conducted from 2020 to 2023. The Newcastle-Ottawa Scale was used to assess study quality. The inventory performed at the Department of Occupational and Environmental Dermatology, Malmö, Sweden (YMDA)... (More)
Background: The use of insulin pumps (continuous subcutaneous insulin infusion [CSII]) in individuals living with type 1 diabetes (T1D) improves disease control. However, adverse skin reactions may hamper compliance. We aimed to assess the relationship of insulin pumps, particularly that of infusion set therapy, used in children and adults with T1D and dermatitis including allergic contact dermatitis (ACD). Methods: A systematic search of PubMed, and EMBASE, of full-text studies reporting dermatitis in persons with diabetes using a CSII was conducted from 2020 to 2023. The Newcastle-Ottawa Scale was used to assess study quality. The inventory performed at the Department of Occupational and Environmental Dermatology, Malmö, Sweden (YMDA) was also performed highlighting the diagnostic process. Results: Among the 391 screened abstracts, 21 studies fulfilled the inclusion criteria. Seven studies included data on children only, four studies were on adults, and nine studies reported data on both children and adults. Participants were exposed to a broad range of pumps. Dermatitis was rarely specified. Up to 60% of those referred to a university hospital due to skin reactions possibly related to insulin pumps had an ACD. Conclusions: The review and our findings indicate that there is not sufficient focus on contact allergy in the primary toxicological evaluations of substances used also for insulin pump therapy products and that possible adverse skin reactions are not correctly followed up in the clinical setting.
(Less)
- author
- von Kobyletzki, Laura Beate
LU
; Ulriksdotter, Josefin
LU
; von Kobyletzki, Elisa LU ; Mowitz, Martin LU ; Jendle, Johan and Svedman, Cecilia LU
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- in press
- subject
- keywords
- allergic, contact, dermatitis, diabetes mellitus, insulin infusion systems, insulin-dependent, prevalence, systematic review
- in
- Journal of diabetes science and technology
- publisher
- Diabetes Technology Society
- external identifiers
-
- scopus:85195918849
- pmid:38853748
- ISSN
- 1932-2968
- DOI
- 10.1177/19322968241252613
- language
- English
- LU publication?
- yes
- id
- a0388de6-0625-4fbe-9424-898197210f73
- date added to LUP
- 2024-09-11 14:10:28
- date last changed
- 2024-09-11 14:11:08
@article{a0388de6-0625-4fbe-9424-898197210f73, abstract = {{<p>Background: The use of insulin pumps (continuous subcutaneous insulin infusion [CSII]) in individuals living with type 1 diabetes (T1D) improves disease control. However, adverse skin reactions may hamper compliance. We aimed to assess the relationship of insulin pumps, particularly that of infusion set therapy, used in children and adults with T1D and dermatitis including allergic contact dermatitis (ACD). Methods: A systematic search of PubMed, and EMBASE, of full-text studies reporting dermatitis in persons with diabetes using a CSII was conducted from 2020 to 2023. The Newcastle-Ottawa Scale was used to assess study quality. The inventory performed at the Department of Occupational and Environmental Dermatology, Malmö, Sweden (YMDA) was also performed highlighting the diagnostic process. Results: Among the 391 screened abstracts, 21 studies fulfilled the inclusion criteria. Seven studies included data on children only, four studies were on adults, and nine studies reported data on both children and adults. Participants were exposed to a broad range of pumps. Dermatitis was rarely specified. Up to 60% of those referred to a university hospital due to skin reactions possibly related to insulin pumps had an ACD. Conclusions: The review and our findings indicate that there is not sufficient focus on contact allergy in the primary toxicological evaluations of substances used also for insulin pump therapy products and that possible adverse skin reactions are not correctly followed up in the clinical setting.</p>}}, author = {{von Kobyletzki, Laura Beate and Ulriksdotter, Josefin and von Kobyletzki, Elisa and Mowitz, Martin and Jendle, Johan and Svedman, Cecilia}}, issn = {{1932-2968}}, keywords = {{allergic; contact; dermatitis; diabetes mellitus; insulin infusion systems; insulin-dependent; prevalence; systematic review}}, language = {{eng}}, publisher = {{Diabetes Technology Society}}, series = {{Journal of diabetes science and technology}}, title = {{Insulin Pump Therapy and Adverse Skin Reactions With Focus on Allergic Contact Dermatitis in Individuals Living With Diabetes Mellitus : A Systematic Review and Clinical-Based Update}}, url = {{http://dx.doi.org/10.1177/19322968241252613}}, doi = {{10.1177/19322968241252613}}, year = {{2024}}, }