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The use of venous blood gas in assessing arterial acid−base and oxygenation status–an analysis of aggregated data from multiple studies evaluating the venous to arterial conversion (v-TAC) method

Shastri, Lisha ; Thomsen, Lars Pilegaard ; Toftegaard, Marianne ; Tygesen, Gitte Boier ; Weinreich, Ulla Møller ; Rychwicka-Kielek, Beate Agnieszka ; Davies, Michael Gordon ; Ekström, Magnus LU orcid ; Rittger, Harald and Kelly, Anne Maree , et al. (2024) In Expert Review of Respiratory Medicine 18(7). p.553-559
Abstract

Background: Several methods exist to reduce the number of arterial blood gases (ABGs). One method, Roche v-TAC, has been evaluated in different patient groups. This paper aggregates data from these studies, in different patient categories using common analysis criteria. Research design and methods: We included studies evaluating v-TAC based on paired arterial and peripheral venous blood samples. Bland-Altman analysis compared measured and calculated arterial values of pH, PCO2, and PO2. Subgroup analyses were performed for normal, chronic hypercapnia and chronic base excess, acute hyper- and hypocapnia, and acute and chronic base deficits. Results: 811 samples from 12 studies were included. Bias and limits of... (More)

Background: Several methods exist to reduce the number of arterial blood gases (ABGs). One method, Roche v-TAC, has been evaluated in different patient groups. This paper aggregates data from these studies, in different patient categories using common analysis criteria. Research design and methods: We included studies evaluating v-TAC based on paired arterial and peripheral venous blood samples. Bland-Altman analysis compared measured and calculated arterial values of pH, PCO2, and PO2. Subgroup analyses were performed for normal, chronic hypercapnia and chronic base excess, acute hyper- and hypocapnia, and acute and chronic base deficits. Results: 811 samples from 12 studies were included. Bias and limits of agreement for measured and calculated values: pH 0.001 (−0.029 to 0.031), PCO2 −0.08 (−0.65 to 0.49) kPa, and PO2 0.04 (−1.71 to 1.78) kPa, with similar values for all sub-group analyses. Conclusion: These data suggest that v-TAC analysis may have a role in replacing ABGs, avoiding arterial puncture. Substantial data exist in patients with chronic hypercapnia and chronic base excess, acute hyper- and hypocapnia, and in patients with relatively normal acid−base status, with similar bias and precision across groups and across study data. Limited data exist for patients with acute and chronic base deficits.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
emergency medicine, non-invasive ventilation, peripheral venous blood, Pulmonary medicine, respiratory and acid−base status
in
Expert Review of Respiratory Medicine
volume
18
issue
7
pages
7 pages
publisher
Informa Healthcare
external identifiers
  • pmid:38973767
  • scopus:85198501788
ISSN
1747-6348
DOI
10.1080/17476348.2024.2378021
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
id
a09d6c51-1e7c-4f6c-937f-44bce9057cec
date added to LUP
2024-11-27 12:50:22
date last changed
2025-05-29 03:51:56
@article{a09d6c51-1e7c-4f6c-937f-44bce9057cec,
  abstract     = {{<p>Background: Several methods exist to reduce the number of arterial blood gases (ABGs). One method, Roche v-TAC, has been evaluated in different patient groups. This paper aggregates data from these studies, in different patient categories using common analysis criteria. Research design and methods: We included studies evaluating v-TAC based on paired arterial and peripheral venous blood samples. Bland-Altman analysis compared measured and calculated arterial values of pH, PCO<sub>2</sub>, and PO<sub>2</sub>. Subgroup analyses were performed for normal, chronic hypercapnia and chronic base excess, acute hyper- and hypocapnia, and acute and chronic base deficits. Results: 811 samples from 12 studies were included. Bias and limits of agreement for measured and calculated values: pH 0.001 (−0.029 to 0.031), PCO<sub>2</sub> −0.08 (−0.65 to 0.49) kPa, and PO<sub>2</sub> 0.04 (−1.71 to 1.78) kPa, with similar values for all sub-group analyses. Conclusion: These data suggest that v-TAC analysis may have a role in replacing ABGs, avoiding arterial puncture. Substantial data exist in patients with chronic hypercapnia and chronic base excess, acute hyper- and hypocapnia, and in patients with relatively normal acid−base status, with similar bias and precision across groups and across study data. Limited data exist for patients with acute and chronic base deficits.</p>}},
  author       = {{Shastri, Lisha and Thomsen, Lars Pilegaard and Toftegaard, Marianne and Tygesen, Gitte Boier and Weinreich, Ulla Møller and Rychwicka-Kielek, Beate Agnieszka and Davies, Michael Gordon and Ekström, Magnus and Rittger, Harald and Kelly, Anne Maree and Kristensen, Søren Risom and Kjærgaard, Søren and Kamperidis, Panagiotis and Manuel, Ari and Damgaard, Kjeld Asbjørn and Andreassen, Steen and Rees, Stephen Edward}},
  issn         = {{1747-6348}},
  keywords     = {{emergency medicine; non-invasive ventilation; peripheral venous blood; Pulmonary medicine; respiratory and acid−base status}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{553--559}},
  publisher    = {{Informa Healthcare}},
  series       = {{Expert Review of Respiratory Medicine}},
  title        = {{The use of venous blood gas in assessing arterial acid−base and oxygenation status–an analysis of aggregated data from multiple studies evaluating the venous to arterial conversion (v-TAC) method}},
  url          = {{http://dx.doi.org/10.1080/17476348.2024.2378021}},
  doi          = {{10.1080/17476348.2024.2378021}},
  volume       = {{18}},
  year         = {{2024}},
}