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Plasma phosphorylated tau181 and neurodegeneration in Alzheimer’s disease

Hansson, Oskar LU orcid ; Cullen, Nicholas LU ; Zetterberg, Henrik LU ; Blennow, Kaj LU and Mattsson-Carlgren, Niklas LU orcid (2021) In Annals of Clinical and Translational Neurology 8(1). p.259-265
Abstract

We examined if plasma phosphorylated tau is associated with neurodegeneration in Alzheimer’s disease. We investigated 372 cognitively unimpaired participants, 554 mild cognitive impairment patients, and 141 Alzheimer’s disease dementia patients. Tau phosphorylated at threonine 181, regional cortical thickness (using magnetic resonance imaging) and hypometabolism (using fluorodeoxyglucose positron emission tomography) were measured longitudinally. High plasma tau was associated with hypometabolism and cortical atrophy at baseline and over time, and longitudinally increased tau was associated with accelerated atrophy, but these associations were only observed in Aβ-positive participants. Plasma phosphorylated tau may identify and track... (More)

We examined if plasma phosphorylated tau is associated with neurodegeneration in Alzheimer’s disease. We investigated 372 cognitively unimpaired participants, 554 mild cognitive impairment patients, and 141 Alzheimer’s disease dementia patients. Tau phosphorylated at threonine 181, regional cortical thickness (using magnetic resonance imaging) and hypometabolism (using fluorodeoxyglucose positron emission tomography) were measured longitudinally. High plasma tau was associated with hypometabolism and cortical atrophy at baseline and over time, and longitudinally increased tau was associated with accelerated atrophy, but these associations were only observed in Aβ-positive participants. Plasma phosphorylated tau may identify and track processes linked to neurodegeneration in Alzheimer’s disease.

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author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Clinical and Translational Neurology
volume
8
issue
1
pages
259 - 265
publisher
Wiley-Blackwell
external identifiers
  • scopus:85096851070
  • pmid:33249783
ISSN
2328-9503
DOI
10.1002/acn3.51253
language
English
LU publication?
yes
id
a112528a-7d7b-4ee1-a8fc-497ab716920e
date added to LUP
2020-12-11 14:36:12
date last changed
2024-05-30 01:06:47
@article{a112528a-7d7b-4ee1-a8fc-497ab716920e,
  abstract     = {{<p>We examined if plasma phosphorylated tau is associated with neurodegeneration in Alzheimer’s disease. We investigated 372 cognitively unimpaired participants, 554 mild cognitive impairment patients, and 141 Alzheimer’s disease dementia patients. Tau phosphorylated at threonine 181, regional cortical thickness (using magnetic resonance imaging) and hypometabolism (using fluorodeoxyglucose positron emission tomography) were measured longitudinally. High plasma tau was associated with hypometabolism and cortical atrophy at baseline and over time, and longitudinally increased tau was associated with accelerated atrophy, but these associations were only observed in Aβ-positive participants. Plasma phosphorylated tau may identify and track processes linked to neurodegeneration in Alzheimer’s disease.</p>}},
  author       = {{Hansson, Oskar and Cullen, Nicholas and Zetterberg, Henrik and Blennow, Kaj and Mattsson-Carlgren, Niklas}},
  issn         = {{2328-9503}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{259--265}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Annals of Clinical and Translational Neurology}},
  title        = {{Plasma phosphorylated tau181 and neurodegeneration in Alzheimer’s disease}},
  url          = {{http://dx.doi.org/10.1002/acn3.51253}},
  doi          = {{10.1002/acn3.51253}},
  volume       = {{8}},
  year         = {{2021}},
}