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Active sensitization to dimethylthiocarbamylbenzothiazol sulphide : An unexpectedly strong rubber contact allergen

Isaksson, Marléne LU ; Bergendorff, Ola LU ; Hamnerius, Nils LU ; Pontén, Ann LU ; Svedman, Cecilia LU ; Hauksson, Inese LU and Bruze, Magnus LU (2023) In Contact Dermatitis 88(6). p.472-479
Abstract

Background: The two dialkylthiocarbamyl benzothiazole sulphides, dimethyl-thiocarbamylbenzothiazole sulphide (DMTBS) and diethylthio-carbamylbenzothiazole sulphide (DETBS) were shown to be good markers of both thiuram and mercaptobenzothiazole sensitivity. Objectives: To investigate if DMTBS and/or DETBS could be better markers of contact allergy to common rubber additives than the ones currently used. Methods: Sixty-eight dermatitis patients were patch tested with DMTBS and DETBS, both at 1% in petrolatum (pet). Because of late reactions in 10 patients, these were retested to DMTBS and DETBS in serial dilutions. Tetramethylthiuram monosulphide (TMTM) 1.0% pet was also tested. Results: At the initial reading Days 3 and 7, no reactions... (More)

Background: The two dialkylthiocarbamyl benzothiazole sulphides, dimethyl-thiocarbamylbenzothiazole sulphide (DMTBS) and diethylthio-carbamylbenzothiazole sulphide (DETBS) were shown to be good markers of both thiuram and mercaptobenzothiazole sensitivity. Objectives: To investigate if DMTBS and/or DETBS could be better markers of contact allergy to common rubber additives than the ones currently used. Methods: Sixty-eight dermatitis patients were patch tested with DMTBS and DETBS, both at 1% in petrolatum (pet). Because of late reactions in 10 patients, these were retested to DMTBS and DETBS in serial dilutions. Tetramethylthiuram monosulphide (TMTM) 1.0% pet was also tested. Results: At the initial reading Days 3 and 7, no reactions were noted to DMTBS or DETBS. At retesting, 10 of the 68 (15%) patients reacted positively to lower concentrations of DMTBS than the initial test concentration. Seven of 8 also reacted to TMTM. Three of them had positive reactions to DEBTS. All 10 patients had reactions to more diluted solutions to DMBTS than to DEBTS (p = 0.0077; Mc-Nemar test, two-sided). Conclusions: Results speak for patch test sensitization to DMTBS with cross-reactivity to TMTM and also DEBTS. DMTBS and DEBTS could be new markers of rubber allergy but a safe test concentration must be found.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
allergic contact dermatitis, contact allergy, delayed hypersensitivity, patch testing, rubber chemicals
in
Contact Dermatitis
volume
88
issue
6
pages
8 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:36975130
  • scopus:85151453422
ISSN
0105-1873
DOI
10.1111/cod.14311
language
English
LU publication?
yes
id
a53ff229-ba9c-45cd-83b8-22337bac727b
date added to LUP
2023-05-23 15:23:24
date last changed
2024-07-27 07:40:40
@article{a53ff229-ba9c-45cd-83b8-22337bac727b,
  abstract     = {{<p>Background: The two dialkylthiocarbamyl benzothiazole sulphides, dimethyl-thiocarbamylbenzothiazole sulphide (DMTBS) and diethylthio-carbamylbenzothiazole sulphide (DETBS) were shown to be good markers of both thiuram and mercaptobenzothiazole sensitivity. Objectives: To investigate if DMTBS and/or DETBS could be better markers of contact allergy to common rubber additives than the ones currently used. Methods: Sixty-eight dermatitis patients were patch tested with DMTBS and DETBS, both at 1% in petrolatum (pet). Because of late reactions in 10 patients, these were retested to DMTBS and DETBS in serial dilutions. Tetramethylthiuram monosulphide (TMTM) 1.0% pet was also tested. Results: At the initial reading Days 3 and 7, no reactions were noted to DMTBS or DETBS. At retesting, 10 of the 68 (15%) patients reacted positively to lower concentrations of DMTBS than the initial test concentration. Seven of 8 also reacted to TMTM. Three of them had positive reactions to DEBTS. All 10 patients had reactions to more diluted solutions to DMBTS than to DEBTS (p = 0.0077; Mc-Nemar test, two-sided). Conclusions: Results speak for patch test sensitization to DMTBS with cross-reactivity to TMTM and also DEBTS. DMTBS and DEBTS could be new markers of rubber allergy but a safe test concentration must be found.</p>}},
  author       = {{Isaksson, Marléne and Bergendorff, Ola and Hamnerius, Nils and Pontén, Ann and Svedman, Cecilia and Hauksson, Inese and Bruze, Magnus}},
  issn         = {{0105-1873}},
  keywords     = {{allergic contact dermatitis; contact allergy; delayed hypersensitivity; patch testing; rubber chemicals}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{472--479}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Active sensitization to dimethylthiocarbamylbenzothiazol sulphide : An unexpectedly strong rubber contact allergen}},
  url          = {{http://dx.doi.org/10.1111/cod.14311}},
  doi          = {{10.1111/cod.14311}},
  volume       = {{88}},
  year         = {{2023}},
}