Mitogen- and stress-activated protein kinase 1 is required for specific signaling responses in dopamine-denervated mouse striatum, but is not necessary for l-DOPA-induced dyskinesia
(2014) In Neuroscience Letters 583. p.76-80- Abstract
In advanced Parkinson's disease, l-DOPA treatment causes the appearance of abnormal involuntary movements or l-DOPA-induced dyskinesia (LID). LID results in part from l-DOPA-induced activation of extracellular signal-regulated kinase (ERK) in the dopamine-denervated striatum. Activated ERK triggers nuclear responses, including phosphorylation of mitogen- and stress-activated protein kinase 1 (MSK1) and histone H3, and transcription of genes such as FosB. To determine the role of MSK1, wild type and MSK1 knockout mice with unilateral 6-hydroxydopamine lesion in the dorsolateral striatum were chronically treated with l-DOPA. The absence of MSK1 had no effect on the lesion or l-DOPA-induced ERK activation, but reduced l-DOPA-induced... (More)
In advanced Parkinson's disease, l-DOPA treatment causes the appearance of abnormal involuntary movements or l-DOPA-induced dyskinesia (LID). LID results in part from l-DOPA-induced activation of extracellular signal-regulated kinase (ERK) in the dopamine-denervated striatum. Activated ERK triggers nuclear responses, including phosphorylation of mitogen- and stress-activated protein kinase 1 (MSK1) and histone H3, and transcription of genes such as FosB. To determine the role of MSK1, wild type and MSK1 knockout mice with unilateral 6-hydroxydopamine lesion in the dorsolateral striatum were chronically treated with l-DOPA. The absence of MSK1 had no effect on the lesion or l-DOPA-induced ERK activation, but reduced l-DOPA-induced phosphorylation of histone H3 and FosB accumulation in the dopamine-denervated striatum. MSK1 deficiency also prevented the increase in Gαolf, the stimulatory α subunit of G protein coupling striatal dopamine D1 receptor to adenylyl cyclase. However, the intensity of LID was similar in MSK1-deficient and wild type mice. In conclusion, l-DOPA-induced activation of MSK1 contributes to histone H3 phosphorylation, induction of FosB, and Gαolf up-regulation but appears not to be necessary for the development of LID.
(Less)
- author
- Alcacer, Cristina LU ; Charbonnier-Beaupel, Fanny ; Corvol, Jean-Christophe ; Girault, Jean-Antoine and Hervé, Denis
- publishing date
- 2014-11-07
- type
- Contribution to journal
- publication status
- published
- keywords
- 6-OHDA, Extracellular signal-regulated kinase, L-DOPA-induced dyskinesia, Parkinson's disease, Signaling
- in
- Neuroscience Letters
- volume
- 583
- pages
- 5 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:84907778920
- pmid:25233866
- ISSN
- 0304-3940
- DOI
- 10.1016/j.neulet.2014.09.018
- language
- English
- LU publication?
- no
- id
- a6018d3c-0cc4-4c0f-a64b-9ad04e86288d
- date added to LUP
- 2017-02-14 16:13:10
- date last changed
- 2024-05-12 07:34:01
@article{a6018d3c-0cc4-4c0f-a64b-9ad04e86288d, abstract = {{<p>In advanced Parkinson's disease, l-DOPA treatment causes the appearance of abnormal involuntary movements or l-DOPA-induced dyskinesia (LID). LID results in part from l-DOPA-induced activation of extracellular signal-regulated kinase (ERK) in the dopamine-denervated striatum. Activated ERK triggers nuclear responses, including phosphorylation of mitogen- and stress-activated protein kinase 1 (MSK1) and histone H3, and transcription of genes such as FosB. To determine the role of MSK1, wild type and MSK1 knockout mice with unilateral 6-hydroxydopamine lesion in the dorsolateral striatum were chronically treated with l-DOPA. The absence of MSK1 had no effect on the lesion or l-DOPA-induced ERK activation, but reduced l-DOPA-induced phosphorylation of histone H3 and FosB accumulation in the dopamine-denervated striatum. MSK1 deficiency also prevented the increase in Gαolf, the stimulatory α subunit of G protein coupling striatal dopamine D1 receptor to adenylyl cyclase. However, the intensity of LID was similar in MSK1-deficient and wild type mice. In conclusion, l-DOPA-induced activation of MSK1 contributes to histone H3 phosphorylation, induction of FosB, and Gαolf up-regulation but appears not to be necessary for the development of LID.</p>}}, author = {{Alcacer, Cristina and Charbonnier-Beaupel, Fanny and Corvol, Jean-Christophe and Girault, Jean-Antoine and Hervé, Denis}}, issn = {{0304-3940}}, keywords = {{6-OHDA; Extracellular signal-regulated kinase; L-DOPA-induced dyskinesia; Parkinson's disease; Signaling}}, language = {{eng}}, month = {{11}}, pages = {{76--80}}, publisher = {{Elsevier}}, series = {{Neuroscience Letters}}, title = {{Mitogen- and stress-activated protein kinase 1 is required for specific signaling responses in dopamine-denervated mouse striatum, but is not necessary for l-DOPA-induced dyskinesia}}, url = {{http://dx.doi.org/10.1016/j.neulet.2014.09.018}}, doi = {{10.1016/j.neulet.2014.09.018}}, volume = {{583}}, year = {{2014}}, }