Oppositely charged polymer-surfactant nanoparticles stabilized by triblock copolymers for enhanced oil loading
Ouverney Ferreira, Matheus LU ; Pereira, Lorena Oliveira ; Chaiben, Stephany ; Lima, Karina Oliveira ; Edler, Karen J. LU
and Percebom, Ana Maria
(2025)
In Colloids and Surfaces A: Physicochemical and Engineering Aspects
704.
- Abstract
When oppositely charged polymers and surfactants combine, they can form a concentrated phase rich in micelles interconnected by polymer chains. Dispersing this concentrated phase as nanoparticles in an aqueous media can be a way to load and deliver hydrophobic ingredients. This study employed triblock copolymers of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide), EOxPOyEOx, also known as poloxamers or pluronics, to disperse the concentrated phase, forming nanoparticles of aggregated micelles connected by the polyion chains. We showed that nanoparticles formed by hexadecyltrimethylammonium bromide (CTAB), poly(acrylic acid) (PAA), and different EOxPOyEOx... (More)
When oppositely charged polymers and surfactants combine, they can form a concentrated phase rich in micelles interconnected by polymer chains. Dispersing this concentrated phase as nanoparticles in an aqueous media can be a way to load and deliver hydrophobic ingredients. This study employed triblock copolymers of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide), EOxPOyEOx, also known as poloxamers or pluronics, to disperse the concentrated phase, forming nanoparticles of aggregated micelles connected by the polyion chains. We showed that nanoparticles formed by hexadecyltrimethylammonium bromide (CTAB), poly(acrylic acid) (PAA), and different EOxPOyEOx copolymers can enhance the loading of oily ingredients compared to pure surfactant micelles. Dispersions with 1.6 wt% of nanoparticles exhibited water-like viscosity and loaded up to 0.48 wt% of oil. Characterization techniques, including dynamic light scattering (DLS), electrophoretic mobility, small-angle X-ray scattering (SAXS), and cryogenic transmission electronic microscopy (cryo-TEM), revealed positively charged spherical 50–180 nm nanoparticles with a core formed by concentrated micelles, that were stable for at least 4 months. Variations in the EO and PO block lengths did not impact morphology, showing that different EOxPOyEOx copolymers were suitable for dispersing the nanoparticles. Increasing EO block length size decreased the diameter of nanoparticles and enhanced stability, providing a means to control their properties. In conclusion, nanoparticles formed by oppositely charged polymer-surfactant mixtures and stabilized by triblock copolymers showed potential for applications, such as sprays, due to their effective oil loading, high stability, and facile preparation.
(Less)
- author
- Ouverney Ferreira, Matheus
LU
; Pereira, Lorena Oliveira
; Chaiben, Stephany
; Lima, Karina Oliveira
; Edler, Karen J.
LU
and Percebom, Ana Maria
- organization
- publishing date
- 2025-01-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Coacervate, Colloids, Core-shell, Encapsulation, Triblock copolymer
- in
- Colloids and Surfaces A: Physicochemical and Engineering Aspects
- volume
- 704
- article number
- 135427
- pages
- 10 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85205026584
- ISSN
- 0927-7757
- DOI
- 10.1016/j.colsurfa.2024.135427
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2024 Elsevier B.V.
- id
- a612a28b-aac0-45b9-96f1-11e37752c2f2
- date added to LUP
- 2024-10-06 16:39:24
- date last changed
- 2025-04-04 14:09:07
@article{a612a28b-aac0-45b9-96f1-11e37752c2f2,
abstract = {{<p>When oppositely charged polymers and surfactants combine, they can form a concentrated phase rich in micelles interconnected by polymer chains. Dispersing this concentrated phase as nanoparticles in an aqueous media can be a way to load and deliver hydrophobic ingredients. This study employed triblock copolymers of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide), EO<sub>x</sub>PO<sub>y</sub>EO<sub>x</sub>, also known as poloxamers or pluronics, to disperse the concentrated phase, forming nanoparticles of aggregated micelles connected by the polyion chains. We showed that nanoparticles formed by hexadecyltrimethylammonium bromide (CTAB), poly(acrylic acid) (PAA), and different EO<sub>x</sub>PO<sub>y</sub>EO<sub>x</sub> copolymers can enhance the loading of oily ingredients compared to pure surfactant micelles. Dispersions with 1.6 wt% of nanoparticles exhibited water-like viscosity and loaded up to 0.48 wt% of oil. Characterization techniques, including dynamic light scattering (DLS), electrophoretic mobility, small-angle X-ray scattering (SAXS), and cryogenic transmission electronic microscopy (cryo-TEM), revealed positively charged spherical 50–180 nm nanoparticles with a core formed by concentrated micelles, that were stable for at least 4 months. Variations in the EO and PO block lengths did not impact morphology, showing that different EO<sub>x</sub>PO<sub>y</sub>EO<sub>x</sub> copolymers were suitable for dispersing the nanoparticles. Increasing EO block length size decreased the diameter of nanoparticles and enhanced stability, providing a means to control their properties. In conclusion, nanoparticles formed by oppositely charged polymer-surfactant mixtures and stabilized by triblock copolymers showed potential for applications, such as sprays, due to their effective oil loading, high stability, and facile preparation.</p>}},
author = {{Ouverney Ferreira, Matheus and Pereira, Lorena Oliveira and Chaiben, Stephany and Lima, Karina Oliveira and Edler, Karen J. and Percebom, Ana Maria}},
issn = {{0927-7757}},
keywords = {{Coacervate; Colloids; Core-shell; Encapsulation; Triblock copolymer}},
language = {{eng}},
month = {{01}},
publisher = {{Elsevier}},
series = {{Colloids and Surfaces A: Physicochemical and Engineering Aspects}},
title = {{Oppositely charged polymer-surfactant nanoparticles stabilized by triblock copolymers for enhanced oil loading}},
url = {{http://dx.doi.org/10.1016/j.colsurfa.2024.135427}},
doi = {{10.1016/j.colsurfa.2024.135427}},
volume = {{704}},
year = {{2025}},
}