Comparing progression biomarkers in clinical trials of early Alzheimer’s disease
Cullen, Nicholas C. LU ; Zetterberg, Henrik LU ; Insel, Philip S. LU ; Olsson, Bob ; Andreasson, Ulf ; Blennow, Kaj LU ; Hansson, Oskar LU
and Mattsson-Carlgren, Niklas
LU
(2020)
In Annals of Clinical and Translational Neurology
7(9).
p.1661-1673
- Abstract
Objective: To investigate the statistical power of plasma, imaging, and cognition biomarkers as Alzheimer’s disease (AD) clinical trial outcome measures. Methods: Plasma neurofilament light, structural magnetic resonance imaging, and cognition were measured longitudinally in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) in control (amyloid PET or CSF Aβ42 negative [Aβ-] with Clinical Dementia Rating scale [CDR] = 0; n = 330), preclinical AD (Aβ + with CDR = 0; n = 218) and mild AD (Aβ + with CDR = 0.5-1; n = 697) individuals. A statistical power analysis was performed across biomarkers and groups based on longitudinal mixed effects modeling and using several different clinical trial designs. Results: For a 30-month trial of... (More)
Objective: To investigate the statistical power of plasma, imaging, and cognition biomarkers as Alzheimer’s disease (AD) clinical trial outcome measures. Methods: Plasma neurofilament light, structural magnetic resonance imaging, and cognition were measured longitudinally in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) in control (amyloid PET or CSF Aβ42 negative [Aβ-] with Clinical Dementia Rating scale [CDR] = 0; n = 330), preclinical AD (Aβ + with CDR = 0; n = 218) and mild AD (Aβ + with CDR = 0.5-1; n = 697) individuals. A statistical power analysis was performed across biomarkers and groups based on longitudinal mixed effects modeling and using several different clinical trial designs. Results: For a 30-month trial of preclinical AD, both the temporal composite and hippocampal volumes were superior to plasma neurofilament light and cognition. For an 18-month trial of mild AD, hippocampal volume was superior to all other biomarkers. Plasma neurofilament light became more effective with increased trial duration or sampling frequency. Imaging biomarkers were characterized by high slope and low within-subject variability, while plasma neurofilament light and cognition were characterized by higher within-subject variability. Interpretation: MRI measures had properties that made them preferable to cognition and pNFL as outcome measures in clinical trials of early AD, regardless of cognitive status. However, pNfL and cognition can still be effective depending on inclusion criteria, sampling frequency, and response to therapy. Future trials will help to understand how sensitive pNfL and MRI are to detect downstream effects on neurodegeneration of drugs targeting amyloid and tau pathology in AD.
(Less)
- author
- Cullen, Nicholas C.
LU
; Zetterberg, Henrik
LU
; Insel, Philip S.
LU
; Olsson, Bob
; Andreasson, Ulf
; Blennow, Kaj
LU
; Hansson, Oskar
LU
and Mattsson-Carlgren, Niklas
LU
- organization
- publishing date
- 2020-09
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annals of Clinical and Translational Neurology
- volume
- 7
- issue
- 9
- pages
- 13 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85089254377
- pmid:32779869
- ISSN
- 2328-9503
- DOI
- 10.1002/acn3.51158
- project
- Blood-based biomarkers for prognosis of early Alzheimer's disease
- language
- English
- LU publication?
- yes
- id
- a9adfa40-17b3-4d48-b11a-5cfed9f3c2e6
- date added to LUP
- 2020-08-19 09:50:13
- date last changed
- 2024-05-29 17:59:06
@article{a9adfa40-17b3-4d48-b11a-5cfed9f3c2e6,
abstract = {{<p>Objective: To investigate the statistical power of plasma, imaging, and cognition biomarkers as Alzheimer’s disease (AD) clinical trial outcome measures. Methods: Plasma neurofilament light, structural magnetic resonance imaging, and cognition were measured longitudinally in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) in control (amyloid PET or CSF Aβ42 negative [Aβ-] with Clinical Dementia Rating scale [CDR] = 0; n = 330), preclinical AD (Aβ + with CDR = 0; n = 218) and mild AD (Aβ + with CDR = 0.5-1; n = 697) individuals. A statistical power analysis was performed across biomarkers and groups based on longitudinal mixed effects modeling and using several different clinical trial designs. Results: For a 30-month trial of preclinical AD, both the temporal composite and hippocampal volumes were superior to plasma neurofilament light and cognition. For an 18-month trial of mild AD, hippocampal volume was superior to all other biomarkers. Plasma neurofilament light became more effective with increased trial duration or sampling frequency. Imaging biomarkers were characterized by high slope and low within-subject variability, while plasma neurofilament light and cognition were characterized by higher within-subject variability. Interpretation: MRI measures had properties that made them preferable to cognition and pNFL as outcome measures in clinical trials of early AD, regardless of cognitive status. However, pNfL and cognition can still be effective depending on inclusion criteria, sampling frequency, and response to therapy. Future trials will help to understand how sensitive pNfL and MRI are to detect downstream effects on neurodegeneration of drugs targeting amyloid and tau pathology in AD.</p>}},
author = {{Cullen, Nicholas C. and Zetterberg, Henrik and Insel, Philip S. and Olsson, Bob and Andreasson, Ulf and Blennow, Kaj and Hansson, Oskar and Mattsson-Carlgren, Niklas}},
issn = {{2328-9503}},
language = {{eng}},
number = {{9}},
pages = {{1661--1673}},
publisher = {{Wiley-Blackwell}},
series = {{Annals of Clinical and Translational Neurology}},
title = {{Comparing progression biomarkers in clinical trials of early Alzheimer’s disease}},
url = {{http://dx.doi.org/10.1002/acn3.51158}},
doi = {{10.1002/acn3.51158}},
volume = {{7}},
year = {{2020}},
}