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Proteomic Investigation in Plasma from Women with Fibromyalgia in Response to a 15-wk Resistance Exercise Intervention

Wåhlén, Karin ; Yan, Hong LU ; Welinder, Charlotte LU ; Ernberg, Malin ; Kosek, Eva ; Mannerkorpi, Kaisa LU ; Gerdle, Björn and Ghafouri, Bijar (2022) In Medicine and Science in Sports and Exercise 54(2). p.232-246
Abstract

PURPOSE: Fibromyalgia (FM) is a complex pain condition, and exercise is considered the first option of treatment. Few studies have examined the effect of exercise on molecular mechanisms in FM. The aim of this study was to analyze the plasma proteome in women with FM and healthy controls (CON) before and after 15 wk of resistance exercise. This study further investigated whether clinical and exercises-related outcomes correlated with identified plasma proteins in FM. METHODS: Plasma samples from 40 FM/25 CON (baseline) and 21 FM/24 CON (postexercise) were analyzed using shotgun proteomics. Clinical/background data were retrieved through questionnaires. Exercise-related variables and pressure pain thresholds were assessed using... (More)

PURPOSE: Fibromyalgia (FM) is a complex pain condition, and exercise is considered the first option of treatment. Few studies have examined the effect of exercise on molecular mechanisms in FM. The aim of this study was to analyze the plasma proteome in women with FM and healthy controls (CON) before and after 15 wk of resistance exercise. This study further investigated whether clinical and exercises-related outcomes correlated with identified plasma proteins in FM. METHODS: Plasma samples from 40 FM/25 CON (baseline) and 21 FM/24 CON (postexercise) were analyzed using shotgun proteomics. Clinical/background data were retrieved through questionnaires. Exercise-related variables and pressure pain thresholds were assessed using standardized instruments. Multivariate statistics were applied to analyze the proteomic profile at baseline and postexercise, and correlation with clinical/exercise-related data. RESULTS: Fifteen weeks of resistance exercises improved clinical symptoms and muscle strength, and affected circulating proteins related to immunity, stress, mRNA stability, metabolic processes, and muscle structure development in FM. Pressure pain threshold was related to a specific protein profile, with proteins involved in metabolic and immune response. Subgroups of FM based on plasma proteins, FM duration, and improved muscle strength were identified. CONCLUSIONS: Exercise seems to affect circulating proteins, clinical characteristics, and muscle strength in FM. This study contributes to better understanding of systemic protein changes in FM compared with CON and how resistance exercise affects such changes.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Medicine and Science in Sports and Exercise
volume
54
issue
2
pages
15 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:35029590
  • scopus:85123568526
ISSN
1530-0315
DOI
10.1249/MSS.0000000000002790
language
English
LU publication?
yes
id
aa68550e-c2a9-468d-98fb-55a243df638a
date added to LUP
2022-03-28 10:44:36
date last changed
2024-07-16 04:09:13
@article{aa68550e-c2a9-468d-98fb-55a243df638a,
  abstract     = {{<p>PURPOSE: Fibromyalgia (FM) is a complex pain condition, and exercise is considered the first option of treatment. Few studies have examined the effect of exercise on molecular mechanisms in FM. The aim of this study was to analyze the plasma proteome in women with FM and healthy controls (CON) before and after 15 wk of resistance exercise. This study further investigated whether clinical and exercises-related outcomes correlated with identified plasma proteins in FM. METHODS: Plasma samples from 40 FM/25 CON (baseline) and 21 FM/24 CON (postexercise) were analyzed using shotgun proteomics. Clinical/background data were retrieved through questionnaires. Exercise-related variables and pressure pain thresholds were assessed using standardized instruments. Multivariate statistics were applied to analyze the proteomic profile at baseline and postexercise, and correlation with clinical/exercise-related data. RESULTS: Fifteen weeks of resistance exercises improved clinical symptoms and muscle strength, and affected circulating proteins related to immunity, stress, mRNA stability, metabolic processes, and muscle structure development in FM. Pressure pain threshold was related to a specific protein profile, with proteins involved in metabolic and immune response. Subgroups of FM based on plasma proteins, FM duration, and improved muscle strength were identified. CONCLUSIONS: Exercise seems to affect circulating proteins, clinical characteristics, and muscle strength in FM. This study contributes to better understanding of systemic protein changes in FM compared with CON and how resistance exercise affects such changes.</p>}},
  author       = {{Wåhlén, Karin and Yan, Hong and Welinder, Charlotte and Ernberg, Malin and Kosek, Eva and Mannerkorpi, Kaisa and Gerdle, Björn and Ghafouri, Bijar}},
  issn         = {{1530-0315}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{2}},
  pages        = {{232--246}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Medicine and Science in Sports and Exercise}},
  title        = {{Proteomic Investigation in Plasma from Women with Fibromyalgia in Response to a 15-wk Resistance Exercise Intervention}},
  url          = {{http://dx.doi.org/10.1249/MSS.0000000000002790}},
  doi          = {{10.1249/MSS.0000000000002790}},
  volume       = {{54}},
  year         = {{2022}},
}