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Patch testing with a textile dye mix with and without Disperse Orange 3

Stenton, Joanna LU ; Dahlin, Jakob LU ; Antelmi, Annarita LU ; Bruze, Magnus LU ; Svedman, Cecilia LU ; Zimerson, Erik LU ; Hamnerius, Nils LU ; Pontén, Ann LU and Isaksson, Marléne LU (2020) In Contact Dermatitis 83(5). p.387-390
Abstract

Background: The textile dye mix (TDM) 6.6% pet. contains Disperse Blue (DB) 35, Disperse Yellow 3, Disperse Orange (DO) 1 and 3, Disperse Red 1 and 17, and DB 106 and 124. The most frequent allergen in TDM-positive patients is DO 3. Around 85% of p-phenylenediamine (PPD)-allergic dermatitis patients have shown positive patch test reactions to DO 3. There has been a discussion to exclude DO 3 from TDM 6.6% because of frequent, strong reactions to TDM 6.6% and PPD. Objectives: To study if DO 3 can be omitted from a TDM. Methods: Patch tests were performed on 2250 dermatitis patients with TDM 6.6%, TDM 5.6% pet., TDM 7.0% pet., and PPD 1.0% pet.; 122 patients were also patch tested with DO 3 1.0% pet. Results: Among the 2250 patients patch... (More)

Background: The textile dye mix (TDM) 6.6% pet. contains Disperse Blue (DB) 35, Disperse Yellow 3, Disperse Orange (DO) 1 and 3, Disperse Red 1 and 17, and DB 106 and 124. The most frequent allergen in TDM-positive patients is DO 3. Around 85% of p-phenylenediamine (PPD)-allergic dermatitis patients have shown positive patch test reactions to DO 3. There has been a discussion to exclude DO 3 from TDM 6.6% because of frequent, strong reactions to TDM 6.6% and PPD. Objectives: To study if DO 3 can be omitted from a TDM. Methods: Patch tests were performed on 2250 dermatitis patients with TDM 6.6%, TDM 5.6% pet., TDM 7.0% pet., and PPD 1.0% pet.; 122 patients were also patch tested with DO 3 1.0% pet. Results: Among the 2250 patients patch tested, contact allergy prevalence to TDM 6.6% was 2.4%, to TDM 5.6% 1.8%, and to TDM 7.0% 2.0%. Of the 54 TDM 6.6%-positive patients, 55.6% reacted to PPD; as much as 42.2% of PPD-allergic women and 50% of PPD-allergic men reacted to TDM 6.6%. Of the 17 DO 3-positive patients, 94.1% showed a positive reaction to PPD. Conclusion: Results indicate that DO 3 can probably be omitted from TDM, but patch testing with TDM 6.6%, TDM 7.0%, DO 3 1.0%, and PPD 1.0% simultaneously is needed to finally decide whether it is possible or not.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
baseline series, contact allergy, disperse dyes, Disperse Orange 3, p-phenylenediamine, patch testing, simultaneous reactivity, textile dye mix
in
Contact Dermatitis
volume
83
issue
5
pages
387 - 390
publisher
Wiley-Blackwell
external identifiers
  • scopus:85090942498
  • pmid:32666533
ISSN
0105-1873
DOI
10.1111/cod.13660
language
English
LU publication?
yes
id
ad928a5b-588c-4fe4-9dcc-56e64e4b6be3
date added to LUP
2020-10-21 09:17:11
date last changed
2024-05-29 21:12:00
@article{ad928a5b-588c-4fe4-9dcc-56e64e4b6be3,
  abstract     = {{<p>Background: The textile dye mix (TDM) 6.6% pet. contains Disperse Blue (DB) 35, Disperse Yellow 3, Disperse Orange (DO) 1 and 3, Disperse Red 1 and 17, and DB 106 and 124. The most frequent allergen in TDM-positive patients is DO 3. Around 85% of p-phenylenediamine (PPD)-allergic dermatitis patients have shown positive patch test reactions to DO 3. There has been a discussion to exclude DO 3 from TDM 6.6% because of frequent, strong reactions to TDM 6.6% and PPD. Objectives: To study if DO 3 can be omitted from a TDM. Methods: Patch tests were performed on 2250 dermatitis patients with TDM 6.6%, TDM 5.6% pet., TDM 7.0% pet., and PPD 1.0% pet.; 122 patients were also patch tested with DO 3 1.0% pet. Results: Among the 2250 patients patch tested, contact allergy prevalence to TDM 6.6% was 2.4%, to TDM 5.6% 1.8%, and to TDM 7.0% 2.0%. Of the 54 TDM 6.6%-positive patients, 55.6% reacted to PPD; as much as 42.2% of PPD-allergic women and 50% of PPD-allergic men reacted to TDM 6.6%. Of the 17 DO 3-positive patients, 94.1% showed a positive reaction to PPD. Conclusion: Results indicate that DO 3 can probably be omitted from TDM, but patch testing with TDM 6.6%, TDM 7.0%, DO 3 1.0%, and PPD 1.0% simultaneously is needed to finally decide whether it is possible or not.</p>}},
  author       = {{Stenton, Joanna and Dahlin, Jakob and Antelmi, Annarita and Bruze, Magnus and Svedman, Cecilia and Zimerson, Erik and Hamnerius, Nils and Pontén, Ann and Isaksson, Marléne}},
  issn         = {{0105-1873}},
  keywords     = {{baseline series; contact allergy; disperse dyes; Disperse Orange 3; p-phenylenediamine; patch testing; simultaneous reactivity; textile dye mix}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{387--390}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Patch testing with a textile dye mix with and without Disperse Orange 3}},
  url          = {{http://dx.doi.org/10.1111/cod.13660}},
  doi          = {{10.1111/cod.13660}},
  volume       = {{83}},
  year         = {{2020}},
}