Fate of intravenously administerd particulate and lipoprotein choletserol in the rat
(1972) In Journal of Lipid Research 13(1). p.32-38- Abstract
- Unesterified radioactive cholesterol, both bound to serum lipoproteins and dispersed in ethanol-saline, was injected into bile fistula and intact rats. Due to phagocytosis, mainly by the liver macrophages, intravenously injected cholesterol in ethanol-saline disappears from the bloodstream significantly faster than lipoprotein-bound cholesterol. Soon after the initial phagocytosis, the particulate isotopic cholesterol started to reappear in blood, reaching a maximal radioactivity in blood 10-24 hr after injection. Although the radioactive cholesterol reappears in serum in both esterified and unesterified form, it is likely that cholesterol is released from the phagocytic cells as unesterified cholesterol which is then esterified... (More)
- Unesterified radioactive cholesterol, both bound to serum lipoproteins and dispersed in ethanol-saline, was injected into bile fistula and intact rats. Due to phagocytosis, mainly by the liver macrophages, intravenously injected cholesterol in ethanol-saline disappears from the bloodstream significantly faster than lipoprotein-bound cholesterol. Soon after the initial phagocytosis, the particulate isotopic cholesterol started to reappear in blood, reaching a maximal radioactivity in blood 10-24 hr after injection. Although the radioactive cholesterol reappears in serum in both esterified and unesterified form, it is likely that cholesterol is released from the phagocytic cells as unesterified cholesterol which is then esterified intravascularly or at other sites. In the bile fistula rats, somewhat more of the lipoprotein cholesterol than of the particulate cholesterol appeared in bile early after injection. However, cholesterol turnover calculated from a twopool model was the same for rats injected with lipoproteinbound or particulate cholesterol. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/aeb7872d-5546-4750-9376-38ffb9fd2bf1
- author
- Nilsson, Åke LU and Zilversmit, Donald
- organization
- publishing date
- 1972-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Lipid Research
- volume
- 13
- issue
- 1
- pages
- 32 - 38
- publisher
- American Society for Biochemistry and Molecular Biology
- external identifiers
-
- pmid:5059197
- scopus:0015470363
- ISSN
- 1539-7262
- language
- English
- LU publication?
- yes
- id
- aeb7872d-5546-4750-9376-38ffb9fd2bf1
- alternative location
- http://www.jlr.org/content/13/1/32.long
- date added to LUP
- 2019-06-01 19:36:03
- date last changed
- 2024-01-04 22:34:33
@article{aeb7872d-5546-4750-9376-38ffb9fd2bf1,
abstract = {{Unesterified radioactive cholesterol, both bound to serum lipoproteins and dispersed in ethanol-saline, was injected into bile fistula and intact rats. Due to phagocytosis, mainly by the liver macrophages, intravenously injected cholesterol in ethanol-saline disappears from the bloodstream significantly faster than lipoprotein-bound cholesterol. Soon after the initial phagocytosis, the particulate isotopic cholesterol started to reappear in blood, reaching a maximal radioactivity in blood 10-24 hr after injection. Although the radioactive cholesterol reappears in serum in both esterified and unesterified form, it is likely that cholesterol is released from the phagocytic cells as unesterified cholesterol which is then esterified intravascularly or at other sites. In the bile fistula rats, somewhat more of the lipoprotein cholesterol than of the particulate cholesterol appeared in bile early after injection. However, cholesterol turnover calculated from a twopool model was the same for rats injected with lipoproteinbound or particulate cholesterol.}},
author = {{Nilsson, Åke and Zilversmit, Donald}},
issn = {{1539-7262}},
language = {{eng}},
month = {{01}},
number = {{1}},
pages = {{32--38}},
publisher = {{American Society for Biochemistry and Molecular Biology}},
series = {{Journal of Lipid Research}},
title = {{Fate of intravenously administerd particulate and lipoprotein choletserol in the rat}},
url = {{http://www.jlr.org/content/13/1/32.long}},
volume = {{13}},
year = {{1972}},
}