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MicroRNAs as potential architects of immune dysregulation and megakaryocytic failure in immune thrombocytopenia

Liu, Zhenyu LU ; Rebetz, Johan LU orcid ; Garabet, Lamya ; Ghanima, Waleed ; Xu, Peipei ; Wadenvik, Hans ; Provan, Drew ; Kapur, Rick and Semple, John W. LU (2026) In British Journal of Haematology
Abstract

Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this multicellular immune network remain largely elusive. This review explores the hypothesis that microRNAs (miRNAs) may serve as critical architects of immune dysregulation and bone marrow failure in ITP. We evaluate the clinical utility of circulating miRNAs as non-invasive biomarkers for diagnosis, risk stratification and predicting response to steroid and thrombopoietin receptor agonists therapies. Finally,... (More)

Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this multicellular immune network remain largely elusive. This review explores the hypothesis that microRNAs (miRNAs) may serve as critical architects of immune dysregulation and bone marrow failure in ITP. We evaluate the clinical utility of circulating miRNAs as non-invasive biomarkers for diagnosis, risk stratification and predicting response to steroid and thrombopoietin receptor agonists therapies. Finally, we address current translational difficulties, such as data fragmentation and pre-analytical variables. We propose a roadmap for integrating functional validation with multi-omics, utilizing miRNA-based approaches to facilitate and advance precision medicine in ITP.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
immunity, immunoregulation, ITP, microRNA (miRNA)
in
British Journal of Haematology
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:41983341
  • scopus:105035776754
ISSN
0007-1048
DOI
10.1111/bjh.70485
language
English
LU publication?
yes
id
afc5b94c-b4cb-4e99-b3d2-f54bf73bfece
date added to LUP
2026-06-24 11:56:46
date last changed
2026-09-03 23:57:31
@article{afc5b94c-b4cb-4e99-b3d2-f54bf73bfece,
  abstract     = {{<p>Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this multicellular immune network remain largely elusive. This review explores the hypothesis that microRNAs (miRNAs) may serve as critical architects of immune dysregulation and bone marrow failure in ITP. We evaluate the clinical utility of circulating miRNAs as non-invasive biomarkers for diagnosis, risk stratification and predicting response to steroid and thrombopoietin receptor agonists therapies. Finally, we address current translational difficulties, such as data fragmentation and pre-analytical variables. We propose a roadmap for integrating functional validation with multi-omics, utilizing miRNA-based approaches to facilitate and advance precision medicine in ITP.</p>}},
  author       = {{Liu, Zhenyu and Rebetz, Johan and Garabet, Lamya and Ghanima, Waleed and Xu, Peipei and Wadenvik, Hans and Provan, Drew and Kapur, Rick and Semple, John W.}},
  issn         = {{0007-1048}},
  keywords     = {{immunity; immunoregulation; ITP; microRNA (miRNA)}},
  language     = {{eng}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{British Journal of Haematology}},
  title        = {{MicroRNAs as potential architects of immune dysregulation and megakaryocytic failure in immune thrombocytopenia}},
  url          = {{http://dx.doi.org/10.1111/bjh.70485}},
  doi          = {{10.1111/bjh.70485}},
  year         = {{2026}},
}