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Association of ventricular-arterial coupling with biomarkers involved in heart failure pathophysiology - the STANISLAS cohort

Holm, Hannes LU ; Magnusson, Martin LU orcid ; Jujić, Amra LU ; Lagrange, Jérémy ; Bozec, Erwan ; Lamiral, Zohra ; Bresso, Emmanuel ; Huttin, Olivier ; Baudry, Guillaume and Monzo, Luca , et al. (2024) In European Journal of Heart Failure
Abstract

AIMS: Impaired left ventricular-arterial coupling (VAC) has been shown to correlate with worse prognosis in cardiac diseases and heart failure (HF). The extent of the relationship between VAC and circulating biomarkers associated with HF has been scarcely documented. We aimed to explore associations of VAC with proteins involved in HF pathophysiology within a large population-based cohort of middle-aged individuals.

METHODS AND RESULTS: In the forth visit of the STANISLAS family cohort, involving 1309 participants (mean age 48 ± 14 years; 48% male) from parent and children generations, we analysed the association of 32 HF-related proteins with non-invasively assessed VAC using pulse wave velocity (PWV)/global longitudinal strain... (More)

AIMS: Impaired left ventricular-arterial coupling (VAC) has been shown to correlate with worse prognosis in cardiac diseases and heart failure (HF). The extent of the relationship between VAC and circulating biomarkers associated with HF has been scarcely documented. We aimed to explore associations of VAC with proteins involved in HF pathophysiology within a large population-based cohort of middle-aged individuals.

METHODS AND RESULTS: In the forth visit of the STANISLAS family cohort, involving 1309 participants (mean age 48 ± 14 years; 48% male) from parent and children generations, we analysed the association of 32 HF-related proteins with non-invasively assessed VAC using pulse wave velocity (PWV)/global longitudinal strain (GLS) and arterial elastance (E
a)/ventricular end-systolic elastance (E
es). Among the 32 tested proteins, fatty acid-binding protein adipocyte 4, interleukin-6, growth differentiation factor 15, matrix metalloproteinase (MMP)-1, and MMP-9 and adrenomedullin were positively associated with PWV/GLS whereas transforming growth factor beta receptor type 3, MMP-2 and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were negatively associated. In multivariable models, only MMP-2 and NT-proBNP were significantly and inversely associated with PWV/GLS in the whole population and in the parent generation. Higher levels of NT-proBNP were also negatively associated with E
a/E
es in the whole cohort but this association did not persist in the parent subgroup.

CONCLUSION: Elevated MMP-2 and NT-proBNP levels correlate with better VAC (lower PWV/GLS), possibly indicating a compensatory cardiovascular response to regulate left ventricular pressure amidst cardiac remodelling and overload.

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organization
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Contribution to journal
publication status
epub
subject
in
European Journal of Heart Failure
publisher
Elsevier
external identifiers
  • scopus:85202146675
  • pmid:39189882
ISSN
1879-0844
DOI
10.1002/ejhf.3411
language
English
LU publication?
yes
additional info
© 2024 The Author(s). European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
id
aff48069-faf7-4f71-ba97-63a09f8cf409
date added to LUP
2024-09-04 09:21:14
date last changed
2024-09-05 04:03:30
@article{aff48069-faf7-4f71-ba97-63a09f8cf409,
  abstract     = {{<p>AIMS: Impaired left ventricular-arterial coupling (VAC) has been shown to correlate with worse prognosis in cardiac diseases and heart failure (HF). The extent of the relationship between VAC and circulating biomarkers associated with HF has been scarcely documented. We aimed to explore associations of VAC with proteins involved in HF pathophysiology within a large population-based cohort of middle-aged individuals.</p><p>METHODS AND RESULTS: In the forth visit of the STANISLAS family cohort, involving 1309 participants (mean age 48 ± 14 years; 48% male) from parent and children generations, we analysed the association of 32 HF-related proteins with non-invasively assessed VAC using pulse wave velocity (PWV)/global longitudinal strain (GLS) and arterial elastance (E<br>
 a)/ventricular end-systolic elastance (E<br>
 es). Among the 32 tested proteins, fatty acid-binding protein adipocyte 4, interleukin-6, growth differentiation factor 15, matrix metalloproteinase (MMP)-1, and MMP-9 and adrenomedullin were positively associated with PWV/GLS whereas transforming growth factor beta receptor type 3, MMP-2 and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were negatively associated. In multivariable models, only MMP-2 and NT-proBNP were significantly and inversely associated with PWV/GLS in the whole population and in the parent generation. Higher levels of NT-proBNP were also negatively associated with E<br>
 a/E<br>
 es in the whole cohort but this association did not persist in the parent subgroup.<br>
 </p><p>CONCLUSION: Elevated MMP-2 and NT-proBNP levels correlate with better VAC (lower PWV/GLS), possibly indicating a compensatory cardiovascular response to regulate left ventricular pressure amidst cardiac remodelling and overload.</p>}},
  author       = {{Holm, Hannes and Magnusson, Martin and Jujić, Amra and Lagrange, Jérémy and Bozec, Erwan and Lamiral, Zohra and Bresso, Emmanuel and Huttin, Olivier and Baudry, Guillaume and Monzo, Luca and Rossignol, Patrick and Zannad, Faiez and Girerd, Nicolas}},
  issn         = {{1879-0844}},
  language     = {{eng}},
  month        = {{08}},
  publisher    = {{Elsevier}},
  series       = {{European Journal of Heart Failure}},
  title        = {{Association of ventricular-arterial coupling with biomarkers involved in heart failure pathophysiology - the STANISLAS cohort}},
  url          = {{http://dx.doi.org/10.1002/ejhf.3411}},
  doi          = {{10.1002/ejhf.3411}},
  year         = {{2024}},
}