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Arterial stiffness in regards to kidney function in middle-aged subjects with metabolic syndrome : Lithuanian high-risk cohort

Laucyte-Cibulskiene, Agne LU orcid ; Ryliskyte, Ligita ; Badaras, Ignas ; Navickas, Petras ; Badariene, Jolita and Laucevicius, Aleksandras (2021) In Blood Pressure Monitoring 26(3). p.191-195
Abstract

Objective The current study aimed to check whether early vascular aging, measured as carotid-femoral pulse wave velocity (cfPWV), is related to kidney function, measured as creatinine-based estimated glomerular filtration (eGFR) and urinary albumin-to-creatinine ratio (UACR), in middle-aged subjects with metabolic syndrome. Methods Participants were recruited from Lithuanian high-risk cohort (LitHiR). The cohort consists of middle-aged individuals with high cardiovascular risk but without overt cardiovascular disease. Participants underwent baseline and second visit hemodynamics measurement, including aortic mean arterial pressure (MAP), cfPWV, crPWV, carotid-intima media thickness measurement (CIMT) and biochemical analysis and all... (More)

Objective The current study aimed to check whether early vascular aging, measured as carotid-femoral pulse wave velocity (cfPWV), is related to kidney function, measured as creatinine-based estimated glomerular filtration (eGFR) and urinary albumin-to-creatinine ratio (UACR), in middle-aged subjects with metabolic syndrome. Methods Participants were recruited from Lithuanian high-risk cohort (LitHiR). The cohort consists of middle-aged individuals with high cardiovascular risk but without overt cardiovascular disease. Participants underwent baseline and second visit hemodynamics measurement, including aortic mean arterial pressure (MAP), cfPWV, crPWV, carotid-intima media thickness measurement (CIMT) and biochemical analysis and all fulfilled NCEP/ ATPIII criteria for metabolic syndrome diagnosis. First of all, we had determined correlations among hemodynamic measurement and eGFR together with albuminuria, expressed as UACR. Then we compared subjects who experienced significant eGFR decline with the remaining population and determining factors influencing this. Results A total of 689 subject data were eligible for analysis. We observed relationship between cfPWV and MAP, crPWV, glucose, BMI, C-reactive protein, waist circumference except kidney function measured as eGFR at the baseline and at the second visit. eGFR was not associated with MAP or albuminuria. Baseline but not second visit UACR significantly positively correlated with cfPWV (r-spearman = 0.146, P = 0.003) and MAP (r-spearman = 0.142, P = 0.005). eGFR decline was mainly observed in subjects with higher baseline eGFR and was independently influenced by increase in cfPWV. Conclusion In middle-aged subjects with prevalent metabolic syndrome eGFR decline is related to aortic and not peripheral arterial stiffening. Better baseline kidney function could be possibly an effect of glomerular hyperfiltration, and it allows us to conclude that this phenomenon indicates early vascular damage and it should be addressed seriously in metabolic syndrome patients with normal kidney function. Blood Press Monit 26: 191–195

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aging, Arterial stiffness, Kidney function, Metabolic syndrome, Pulse wave velocity
in
Blood Pressure Monitoring
volume
26
issue
3
pages
5 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85105677558
  • pmid:33491995
ISSN
1359-5237
DOI
10.1097/MBP.0000000000000510
language
English
LU publication?
yes
id
b04c1460-ff0e-437d-b39e-ef74e5bd09a8
date added to LUP
2021-06-01 15:24:08
date last changed
2025-06-08 03:21:11
@article{b04c1460-ff0e-437d-b39e-ef74e5bd09a8,
  abstract     = {{<p>Objective The current study aimed to check whether early vascular aging, measured as carotid-femoral pulse wave velocity (cfPWV), is related to kidney function, measured as creatinine-based estimated glomerular filtration (eGFR) and urinary albumin-to-creatinine ratio (UACR), in middle-aged subjects with metabolic syndrome. Methods Participants were recruited from Lithuanian high-risk cohort (LitHiR). The cohort consists of middle-aged individuals with high cardiovascular risk but without overt cardiovascular disease. Participants underwent baseline and second visit hemodynamics measurement, including aortic mean arterial pressure (MAP), cfPWV, crPWV, carotid-intima media thickness measurement (CIMT) and biochemical analysis and all fulfilled NCEP/ ATPIII criteria for metabolic syndrome diagnosis. First of all, we had determined correlations among hemodynamic measurement and eGFR together with albuminuria, expressed as UACR. Then we compared subjects who experienced significant eGFR decline with the remaining population and determining factors influencing this. Results A total of 689 subject data were eligible for analysis. We observed relationship between cfPWV and MAP, crPWV, glucose, BMI, C-reactive protein, waist circumference except kidney function measured as eGFR at the baseline and at the second visit. eGFR was not associated with MAP or albuminuria. Baseline but not second visit UACR significantly positively correlated with cfPWV (r-spearman = 0.146, P = 0.003) and MAP (r-spearman = 0.142, P = 0.005). eGFR decline was mainly observed in subjects with higher baseline eGFR and was independently influenced by increase in cfPWV. Conclusion In middle-aged subjects with prevalent metabolic syndrome eGFR decline is related to aortic and not peripheral arterial stiffening. Better baseline kidney function could be possibly an effect of glomerular hyperfiltration, and it allows us to conclude that this phenomenon indicates early vascular damage and it should be addressed seriously in metabolic syndrome patients with normal kidney function. Blood Press Monit 26: 191–195</p>}},
  author       = {{Laucyte-Cibulskiene, Agne and Ryliskyte, Ligita and Badaras, Ignas and Navickas, Petras and Badariene, Jolita and Laucevicius, Aleksandras}},
  issn         = {{1359-5237}},
  keywords     = {{Aging; Arterial stiffness; Kidney function; Metabolic syndrome; Pulse wave velocity}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{3}},
  pages        = {{191--195}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Blood Pressure Monitoring}},
  title        = {{Arterial stiffness in regards to kidney function in middle-aged subjects with metabolic syndrome : Lithuanian high-risk cohort}},
  url          = {{http://dx.doi.org/10.1097/MBP.0000000000000510}},
  doi          = {{10.1097/MBP.0000000000000510}},
  volume       = {{26}},
  year         = {{2021}},
}