Expression and function of the LIM-homeodomain transcription factor Islet-1 in the developing and mature vertebrate retina
(2015) In Experimental Eye Research 138. p.22-31- Abstract
The LIM-homeodomain transcription factor Islet-1 (Isl1) has been widely used as a marker of different subtypes of neurons in the developing and mature retina of vertebrates. During retinal neurogenesis, early Isl1 expression is detected in the nuclei of neuroblasts that give rise to ganglion, amacrine, bipolar, and horizontal cells. In the mature retina, Isl1 expression is restricted to the nuclei of ganglion cells, cholinergic amacrine cells, ON-bipolar cells, and subpopulations of horizontal cells. Recent studies have explored the functional mechanisms of Isl1 during specification and differentiation of these retinal cell types. Thus, conditional inactivation of Isl1 in the developing mouse retina disrupts retinal function, and also... (More)
The LIM-homeodomain transcription factor Islet-1 (Isl1) has been widely used as a marker of different subtypes of neurons in the developing and mature retina of vertebrates. During retinal neurogenesis, early Isl1 expression is detected in the nuclei of neuroblasts that give rise to ganglion, amacrine, bipolar, and horizontal cells. In the mature retina, Isl1 expression is restricted to the nuclei of ganglion cells, cholinergic amacrine cells, ON-bipolar cells, and subpopulations of horizontal cells. Recent studies have explored the functional mechanisms of Isl1 during specification and differentiation of these retinal cell types. Thus, conditional inactivation of Isl1 in the developing mouse retina disrupts retinal function, and also results in optic nerve hypoplasia, marked reductions in mature ganglion, amacrine, and bipolar cells, and a substantial increase in horizontal cells. Furthermore, conditional knockout shows delayed ganglion cell axon growth, ganglion cell axon guidance error, and ganglion cell nerve fiber defasciculation. These data together suggest a possible role for Isl1 in the early differentiation and maintenance of different vertebrate retinal cell types. This review examines whether the expression pattern of Isl1 during vertebrate retinal development is conserved across vertebrate species, and discusses current understanding of the developmental functions of Isl1 in retinogenesis.
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- author
- Bejarano-Escobar, Ruth ; Álvarez-Hernán, Guadalupe LU ; Morona, Ruth ; González, Agustín ; Martín-Partido, Gervasio and Francisco-Morcillo, Javier
- publishing date
- 2015-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Biomarkers/metabolism, Eye/embryology, Humans, LIM-Homeodomain Proteins/metabolism, Neurogenesis/physiology, Retina/embryology, Retinal Neurons/physiology, Transcription Factors/metabolism
- in
- Experimental Eye Research
- volume
- 138
- pages
- 10 pages
- publisher
- Academic Press
- external identifiers
-
- scopus:84947425244
- pmid:26122047
- ISSN
- 0014-4835
- DOI
- 10.1016/j.exer.2015.06.021
- language
- English
- LU publication?
- no
- additional info
- Copyright © 2015 Elsevier Ltd. All rights reserved.
- id
- b07c23f7-45e1-45f8-a1c5-9a2902c0ea62
- date added to LUP
- 2021-12-15 14:07:39
- date last changed
- 2025-04-04 14:03:08
@article{b07c23f7-45e1-45f8-a1c5-9a2902c0ea62,
abstract = {{<p>The LIM-homeodomain transcription factor Islet-1 (Isl1) has been widely used as a marker of different subtypes of neurons in the developing and mature retina of vertebrates. During retinal neurogenesis, early Isl1 expression is detected in the nuclei of neuroblasts that give rise to ganglion, amacrine, bipolar, and horizontal cells. In the mature retina, Isl1 expression is restricted to the nuclei of ganglion cells, cholinergic amacrine cells, ON-bipolar cells, and subpopulations of horizontal cells. Recent studies have explored the functional mechanisms of Isl1 during specification and differentiation of these retinal cell types. Thus, conditional inactivation of Isl1 in the developing mouse retina disrupts retinal function, and also results in optic nerve hypoplasia, marked reductions in mature ganglion, amacrine, and bipolar cells, and a substantial increase in horizontal cells. Furthermore, conditional knockout shows delayed ganglion cell axon growth, ganglion cell axon guidance error, and ganglion cell nerve fiber defasciculation. These data together suggest a possible role for Isl1 in the early differentiation and maintenance of different vertebrate retinal cell types. This review examines whether the expression pattern of Isl1 during vertebrate retinal development is conserved across vertebrate species, and discusses current understanding of the developmental functions of Isl1 in retinogenesis. </p>}},
author = {{Bejarano-Escobar, Ruth and Álvarez-Hernán, Guadalupe and Morona, Ruth and González, Agustín and Martín-Partido, Gervasio and Francisco-Morcillo, Javier}},
issn = {{0014-4835}},
keywords = {{Animals; Biomarkers/metabolism; Eye/embryology; Humans; LIM-Homeodomain Proteins/metabolism; Neurogenesis/physiology; Retina/embryology; Retinal Neurons/physiology; Transcription Factors/metabolism}},
language = {{eng}},
pages = {{22--31}},
publisher = {{Academic Press}},
series = {{Experimental Eye Research}},
title = {{Expression and function of the LIM-homeodomain transcription factor Islet-1 in the developing and mature vertebrate retina}},
url = {{http://dx.doi.org/10.1016/j.exer.2015.06.021}},
doi = {{10.1016/j.exer.2015.06.021}},
volume = {{138}},
year = {{2015}},
}