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Psychosocial Determinants for Self-Reported Health Status in Hemodialysis Patients : A Cohort Analysis of the CONVINCE Randomized Trial

Cromm, K. ; Ngoc Pham, Le Hong ; Jaha, Hanna ; Fischer, Kathrin I. ; Liegl, Gregor ; Schappert, Anna ; Davenport, Andrew ; Barth, C. ; Blankestijn, P. J. and Hegbrant, Jörgen LU , et al. (2025) In Kidney360 6(1). p.76-85
Abstract

Background: We investigated whether psychosocial determinants self-efficacy and social support are associated with Health-Related Quality of Life in hemodialysis patients enrolled in the CONVINCE trial. Methods: We used baseline data from the cohort of patients involved in the CONVINCE randomized trial of hemodiafiltration versus hemodialysis. Measures included age, gender, relationship status, children, housing, education, employment, comorbidities, dialysis schedules, time of first dialysis, residual kidney function, general self-efficacy and social support scores, and PROMIS measurements for health-related quality of life. Associations were analyzed using hierarchical regression. Results: One thousand three hundred and sixty patients... (More)

Background: We investigated whether psychosocial determinants self-efficacy and social support are associated with Health-Related Quality of Life in hemodialysis patients enrolled in the CONVINCE trial. Methods: We used baseline data from the cohort of patients involved in the CONVINCE randomized trial of hemodiafiltration versus hemodialysis. Measures included age, gender, relationship status, children, housing, education, employment, comorbidities, dialysis schedules, time of first dialysis, residual kidney function, general self-efficacy and social support scores, and PROMIS measurements for health-related quality of life. Associations were analyzed using hierarchical regression. Results: One thousand three hundred and sixty patients from CONVINCE were the cohort of interest. Mean age was 62±13.5 years (range 20-92), and 66.9% were men. Self-efficacy was a significant predictor for all health-related quality of life domains: depression (β = -0.36, p < 0.001), anxiety (β = -0.35, p < 0.001), social participation (β = 0.32, p < 0.001), cognition (β = 0.29, p < 0.001), fatigue (β = -0.29, p < 0.001), physical function (β = 0.27, p < 0.001), sleep disturbance (β = -0.23, p < 0.001), pain interference (β = 0.21, p < 0.001), pain intensity (β = -0.17, p < 0.001), interdialytic symptoms (β = -0.14, p = 0.002) and intradialytic symptoms (β = -0.14, p = 0.002). Social support was a significant predictor for cognition (β = 0.21, p < 0.001), sleep disturbance (β = -0.11, p = 0.017) and intradialytic symptoms (β =- 0.11, p = 0.02). Conclusions: Higher general self-efficacy scale scores are associated with improvements in cognition, depression, anxiety, social participation, fatigue, physical function, sleep disturbance, pain interference, interdialytic symptoms, pain intensity and intradialytic symptoms. Associations for self-efficacy are larger than those for social support and stronger than previously reported. It is plausible that targeted psychosocial interventions may improve health outcomes in people on hemodialysis.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Kidney360
volume
6
issue
1
pages
10 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85206612599
  • pmid:39356555
ISSN
2641-7650
DOI
10.34067/KID.0000000599
language
English
LU publication?
yes
id
b4396a20-967d-4eca-84d9-0f1134829592
date added to LUP
2025-01-15 09:19:57
date last changed
2025-07-17 00:21:35
@article{b4396a20-967d-4eca-84d9-0f1134829592,
  abstract     = {{<p>Background: We investigated whether psychosocial determinants self-efficacy and social support are associated with Health-Related Quality of Life in hemodialysis patients enrolled in the CONVINCE trial. Methods: We used baseline data from the cohort of patients involved in the CONVINCE randomized trial of hemodiafiltration versus hemodialysis. Measures included age, gender, relationship status, children, housing, education, employment, comorbidities, dialysis schedules, time of first dialysis, residual kidney function, general self-efficacy and social support scores, and PROMIS measurements for health-related quality of life. Associations were analyzed using hierarchical regression. Results: One thousand three hundred and sixty patients from CONVINCE were the cohort of interest. Mean age was 62±13.5 years (range 20-92), and 66.9% were men. Self-efficacy was a significant predictor for all health-related quality of life domains: depression (β = -0.36, p &lt; 0.001), anxiety (β = -0.35, p &lt; 0.001), social participation (β = 0.32, p &lt; 0.001), cognition (β = 0.29, p &lt; 0.001), fatigue (β = -0.29, p &lt; 0.001), physical function (β = 0.27, p &lt; 0.001), sleep disturbance (β = -0.23, p &lt; 0.001), pain interference (β = 0.21, p &lt; 0.001), pain intensity (β = -0.17, p &lt; 0.001), interdialytic symptoms (β = -0.14, p = 0.002) and intradialytic symptoms (β = -0.14, p = 0.002). Social support was a significant predictor for cognition (β = 0.21, p &lt; 0.001), sleep disturbance (β = -0.11, p = 0.017) and intradialytic symptoms (β =- 0.11, p = 0.02). Conclusions: Higher general self-efficacy scale scores are associated with improvements in cognition, depression, anxiety, social participation, fatigue, physical function, sleep disturbance, pain interference, interdialytic symptoms, pain intensity and intradialytic symptoms. Associations for self-efficacy are larger than those for social support and stronger than previously reported. It is plausible that targeted psychosocial interventions may improve health outcomes in people on hemodialysis.</p>}},
  author       = {{Cromm, K. and Ngoc Pham, Le Hong and Jaha, Hanna and Fischer, Kathrin I. and Liegl, Gregor and Schappert, Anna and Davenport, Andrew and Barth, C. and Blankestijn, P. J. and Hegbrant, Jörgen and Fischer, Felix H. and Strippoli, G. F.M. and Rose, Matthias}},
  issn         = {{2641-7650}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{76--85}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Kidney360}},
  title        = {{Psychosocial Determinants for Self-Reported Health Status in Hemodialysis Patients : A Cohort Analysis of the CONVINCE Randomized Trial}},
  url          = {{http://dx.doi.org/10.34067/KID.0000000599}},
  doi          = {{10.34067/KID.0000000599}},
  volume       = {{6}},
  year         = {{2025}},
}