The association between early-life relative telomere length and childhood neurodevelopment
Feiler, Marina Oktapodas ; Patel, Deven ; Li, Huiqi LU ; Meacham, Philip J. ; Watson, Gene E. ; Shamlaye, Conrad ; Yeates, Alison ; Broberg, Karin LU
and van Wijngaarden, Edwin
(2018)
In NeuroToxicology
65.
p.22-27
- Abstract
Purpose: To examine the association between telomere length and neurodevelopment in children. Methods: We examined the relationship between relative telomere length (rTL) and neurodevelopmental outcomes at 9 and 30 months, and 5 years of age in children enrolled in the Seychelles Child Development Study Nutrition Cohort 1 (NC1). Relative telomere length was measured in cord blood and in child blood at age five. Multivariable linear regression examined associations between neurodevelopmental outcomes and rTL adjusting for relevant covariates. Results: Mean rTL was 1.18 at birth and 0.71 at age five. Increased cord blood rTL was associated with better scores on two neurodevelopmental tests, the psychomotor developmental index (β = 4.01;... (More)
Purpose: To examine the association between telomere length and neurodevelopment in children. Methods: We examined the relationship between relative telomere length (rTL) and neurodevelopmental outcomes at 9 and 30 months, and 5 years of age in children enrolled in the Seychelles Child Development Study Nutrition Cohort 1 (NC1). Relative telomere length was measured in cord blood and in child blood at age five. Multivariable linear regression examined associations between neurodevelopmental outcomes and rTL adjusting for relevant covariates. Results: Mean rTL was 1.18 at birth and 0.71 at age five. Increased cord blood rTL was associated with better scores on two neurodevelopmental tests, the psychomotor developmental index (β = 4.01; 95% confidence interval (CI) = 0.17, 7.85) at age 30 months, and the Woodcock Johnson test of achievement letter-word score (β = 2.88; CI = 1.21–4.56) at age five. The Woodcock Johnson test of achievement letter-word score remained statistically significant after two outliers were excluded (β = 2.83; CI = 0.69, 4.97); the psychomotor developmental index did not (β = 3.62; CI = −1.28, 8.52). None of the neurodevelopmental outcomes at age five were associated with five-year rTL. Conclusion: Although increased cord blood rTL was associated with better test scores for a few neurodevelopmental outcomes, this study found little consistent evidence of an association between rTL and neurodevelopment. Future studies with a larger sample size, longer follow-up, and other relevant biological markers (e.g. oxidative stress) are needed to clarify the role of rTL in neurodevelopment and its relevance as a potential surrogate measure for oxidative stress in the field of developmental neurotoxicity.
(Less)
- author
- Feiler, Marina Oktapodas
; Patel, Deven
; Li, Huiqi
LU
; Meacham, Philip J.
; Watson, Gene E.
; Shamlaye, Conrad
; Yeates, Alison
; Broberg, Karin
LU
and van Wijngaarden, Edwin
- organization
- publishing date
- 2018-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Children, Cognition, Epidemiology, Language
- in
- NeuroToxicology
- volume
- 65
- pages
- 6 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:29360532
- scopus:85041598263
- ISSN
- 0161-813X
- DOI
- 10.1016/j.neuro.2018.01.005
- language
- English
- LU publication?
- yes
- id
- b4e3f519-4f47-4cfd-9473-bac086ce9810
- date added to LUP
- 2018-02-20 12:52:39
- date last changed
- 2024-02-13 17:26:53
@article{b4e3f519-4f47-4cfd-9473-bac086ce9810,
abstract = {{<p>Purpose: To examine the association between telomere length and neurodevelopment in children. Methods: We examined the relationship between relative telomere length (rTL) and neurodevelopmental outcomes at 9 and 30 months, and 5 years of age in children enrolled in the Seychelles Child Development Study Nutrition Cohort 1 (NC1). Relative telomere length was measured in cord blood and in child blood at age five. Multivariable linear regression examined associations between neurodevelopmental outcomes and rTL adjusting for relevant covariates. Results: Mean rTL was 1.18 at birth and 0.71 at age five. Increased cord blood rTL was associated with better scores on two neurodevelopmental tests, the psychomotor developmental index (β = 4.01; 95% confidence interval (CI) = 0.17, 7.85) at age 30 months, and the Woodcock Johnson test of achievement letter-word score (β = 2.88; CI = 1.21–4.56) at age five. The Woodcock Johnson test of achievement letter-word score remained statistically significant after two outliers were excluded (β = 2.83; CI = 0.69, 4.97); the psychomotor developmental index did not (β = 3.62; CI = −1.28, 8.52). None of the neurodevelopmental outcomes at age five were associated with five-year rTL. Conclusion: Although increased cord blood rTL was associated with better test scores for a few neurodevelopmental outcomes, this study found little consistent evidence of an association between rTL and neurodevelopment. Future studies with a larger sample size, longer follow-up, and other relevant biological markers (e.g. oxidative stress) are needed to clarify the role of rTL in neurodevelopment and its relevance as a potential surrogate measure for oxidative stress in the field of developmental neurotoxicity.</p>}},
author = {{Feiler, Marina Oktapodas and Patel, Deven and Li, Huiqi and Meacham, Philip J. and Watson, Gene E. and Shamlaye, Conrad and Yeates, Alison and Broberg, Karin and van Wijngaarden, Edwin}},
issn = {{0161-813X}},
keywords = {{Children; Cognition; Epidemiology; Language}},
language = {{eng}},
month = {{03}},
pages = {{22--27}},
publisher = {{Elsevier}},
series = {{NeuroToxicology}},
title = {{The association between early-life relative telomere length and childhood neurodevelopment}},
url = {{http://dx.doi.org/10.1016/j.neuro.2018.01.005}},
doi = {{10.1016/j.neuro.2018.01.005}},
volume = {{65}},
year = {{2018}},
}