Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
(2021) In Cell 184(1). p.11-75- Abstract
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical... (More)
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant.
(Less)
- author
- contributor
- Balcazar Lopez, Carlos Enrique LU
- author collaboration
- organization
- publishing date
- 2021-01-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Amino Acid Substitution, Aspartic Acid/analysis, COVID-19/epidemiology, Genome, Viral, Glycine/analysis, Humans, Mutation, SARS-CoV-2/genetics, Spike Glycoprotein, Coronavirus/genetics, United Kingdom/epidemiology, Virulence, Whole Genome Sequencing
- in
- Cell
- volume
- 184
- issue
- 1
- pages
- 11 - 75
- publisher
- Cell Press
- external identifiers
-
- pmid:33275900
- scopus:85098925617
- ISSN
- 1097-4172
- DOI
- 10.1016/j.cell.2020.11.020
- language
- English
- LU publication?
- yes
- id
- b6d57e41-d7fc-4a42-9915-4a40c17f4522
- date added to LUP
- 2021-04-11 20:07:51
- date last changed
- 2024-04-20 05:35:33
@article{b6d57e41-d7fc-4a42-9915-4a40c17f4522, abstract = {{<p>Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant.</p>}}, author = {{Volz, Erik and Hill, Verity and McCrone, John T and Price, Anna and Jorgensen, David and O'Toole, Áine and Southgate, Joel and Johnson, Robert and Jackson, Ben and Nascimento, Fabricia F and Rey, Sara M and Nicholls, Samuel M and Colquhoun, Rachel M and da Silva Filipe, Ana and Shepherd, James and Pascall, David J and Shah, Rajiv and Jesudason, Natasha and Li, Kathy and Jarrett, Ruth and Pacchiarini, Nicole and Bull, Matthew and Geidelberg, Lily and Siveroni, Igor and Goodfellow, Ian and Loman, Nicholas J and Pybus, Oliver G and Robertson, David L and Thomson, Emma C and Rambaut, Andrew and Connor, Thomas R}}, issn = {{1097-4172}}, keywords = {{Amino Acid Substitution; Aspartic Acid/analysis; COVID-19/epidemiology; Genome, Viral; Glycine/analysis; Humans; Mutation; SARS-CoV-2/genetics; Spike Glycoprotein, Coronavirus/genetics; United Kingdom/epidemiology; Virulence; Whole Genome Sequencing}}, language = {{eng}}, month = {{01}}, number = {{1}}, pages = {{11--75}}, publisher = {{Cell Press}}, series = {{Cell}}, title = {{Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity}}, url = {{http://dx.doi.org/10.1016/j.cell.2020.11.020}}, doi = {{10.1016/j.cell.2020.11.020}}, volume = {{184}}, year = {{2021}}, }